Bioengineering Center of Regeneration and Formation of Tissues (SC BioCRAFT)

描述(由申请人提供)：通过我们强大的指导计划、出色的设施开发和出色的外部顾问小组审查，我们在全国唯一的生物工程科布雷的第一阶段资助期间取得了显著的成功。从最初的四个项目开始，我们的项目已经扩展到支持和指导13名初级教员，他们总共获得了1000万美元的外部资金，并在期刊上发表了151篇文章。其中五人也获得了独立地位。通过Cobre的这笔资金，我们已经招聘了三名初级生物技术教师和两名高级生物技术教师。克莱姆森为试点项目和核心设施的显著扩展提供了成本分摊支持，最引人注目的是一个新的生物工程创新园区(CUBEInC，1600万美元)和格林维尔医院系统。CUBEInC，29,000平方英尺英国《金融时报》为研究人员和临床医生提供的实验室和网络空间，手术技能设施，以及 会议中心，将作为我们第二阶段Cobre计划的新地点。一座新的生物工程大楼也于2012年在查尔斯顿的MUSC校园开放。这个耗资6000万美元的新设施代表着全州对生物工程和再生医学的日益重视，并容纳了5名全职克莱姆森终身教职跟踪教师的实验室，其中一人是此次续签申请的目标PI。通过第一期Cobre基金，克莱姆森光成像设备(CLIF)现在位于克莱姆森园区的新生命科学大楼，由我们的核心主任特里·布鲁斯博士指导。在第二阶段，我们将在这些成功的基础上，通过我们的南卡罗来纳州组织再生和形成生物工程中心(SC BioCRAFT)，在我们的组织工程研究中扩展基于生物材料的方法，以更基本的分析组织的再生和形成。我们挑选了五名新的优秀研究人员(其中三名是在Cobre第一阶段聘用的)，并提供了启动资金来发展他们在第二阶段的研究。我们还巩固和增加了新的核心专业领域。我们建议一个独特的生物工程和生物成像(B5)核心和细胞、组织和分子分析(CTMA)核心设施来支持该州的初级教员。 这份提案描述了我们的计划，即建立有效的科学合作，以维持SC BioCRAFT超过P20资助，同时加强我们州和全国的生物工程和组织再生科学界。我们的具体目标是：1)通过指导另外五名具有与我们主题相关的兴趣和人才的杰出目标调查人员，扩大与Cobre有关联的资助研究人员的临界质量；2)增强我们的核心，以帮助我们的目标教员成功竞争NIH资金，并与全州的调查人员建立合作，包括Cobre毕业生和具有相关兴趣的非Cobre研究人员；3)促进SC BioCRAFT作为指定的、可持续的大学认可的研究中心的正式认可，以支持从Cobre过渡到来自不同联邦和非联邦来源的长期竞争支持。

DESCRIPTION (provided by applicant): Through our strong mentoring plan, excellent facility development, and outstanding external advisory panel review, we have achieved remarkable success during the Phase I funding of the only bioengineering COBRE in the nation. Begun with only four projects, our program has expanded to support and mentor 13 junior faculty who have collectively received >$10M in external funding, and published 151 journal articles. Five have also received independent status. Through this COBRE funding, we have recruited three junior and two senior BioE faculty. Clemson has provided cost-share support for pilot projects and a significant expansion of core facilities, most notably a new bioengineering innovation campus (CUBEInC, $16M) with the Greenville Hospital System. CUBEInC, with 29,000 sq. ft. of laboratory and networking space for investigators and clinicians, a surgical skills facility, and a conference center, will serve as the new site for our Phase II COBRE initiative. A new bioengineering building was also opened on the MUSC campus in Charleston in 2012. This new $60M facility represents the growing statewide emphasis on bioengineering and regenerative medicine and houses the labs of five full time Clemson tenure track faculty, one of whom is the target PI in this renewal application. Through Phase I COBRE funding, the Clemson Light Imaging Facility (CLIF) is now in the new Life Sciences building on the Clemson campus under the direction of Dr. Terri Bruce, our core director. We will build on these successes in Phase II. We will expand upon biomaterials-based approach in our tissue engineering studies to a more fundamental analysis of tissue regeneration and formation through our South Carolina Bioengineering Center of Regeneration and Formation of Tissues (SC BioCRAFT). We have selected five new outstanding investigators (3 hired during COBRE Phase I) and provided startup funds to develop their research in Phase II. We have also consolidated and added new areas of core expertise. We propose a unique Bioengineering and Bioimaging (B5) Core and Cell, Tissue, and Molecular Analysis (CTMA) core facilities to support junior faculty in the state. This proposal describes our plan to build an effective scientific collaboration to sustain the SC BioCRAFT beyond P20 funding while strengthening the bioengineering and tissue regeneration scientific community in our state and nationally. Our specific aims are to 1) expand the critical mass of funded investigators affiliated with the COBRE through mentoring in research career development of five additional outstanding targeted investigators with interests and talents relevant to our theme; 2) enhance our core to help our targeted faculty compete successfully for NIH funding and forge collaborations with investigators statewide, including COBRE graduates and non-COBRE researchers with relevant interests and; 3) Promote formal recognition of SC BioCRAFT as a designated, sustainable University recognized research center to support the transition from COBRE to long-term competitive support from diverse federal and non-federal sources.