Cancer Center Support Grant

描述（由申请人提供）：赫伯特欧文综合癌症中心（NCC）于1972年被指定为NCI癌症中心，并于1979年获得综合地位。该中心是哥伦比亚大学医学中心的一个组成部分，并与纽约长老会医院（NYPH）。在2003- 2007年期间，中心和纽约公共卫生署承诺提供3.127亿美元，用于：i）基础、临床和人口科学方面的新研究倡议; ii）实验室研究和临床活动的新设施和扩建设施; iii）招聘和方案重组; iv）中心行政办公室的支助; v）过渡资金，以抵消减少的NCI CCSG支助。 2005年，新主任里卡多·达拉-法韦拉（Riccardo Dalla-Favera，医学博士）被任命，并被授予：i）管理新设施的权力，包括欧文癌症研究中心（红十字国际委员会），这是一座专门用于癌症研究的10层新建筑，拥有最先进的实验室（100，000平方英尺）和增量临床赫伯特欧文馆（HIP）的30，000平方英尺空间; ii）广泛的招聘计划，已吸引八名新教员加入中大;及iii）重组及扩充共享资源。主任全面改组了生物医学信息中心的高级领导层，任命了临床研究副主任和基础研究、临床研究、人口科学、生物医学信息学、共享资源和行政管理副主任。癌症研究中心的计划结构已经重组，以增加对癌症的关注和跨学科合作，现在包括来自22个部门和6个学校的216名成员，分配到两个基础研究计划（癌症信号网络和癌症遗传学与表观遗传学），三个疾病特异性计划（乳腺癌，前列腺癌，和类肉瘤的发展和乳腺癌），和两个人口科学计划（癌症流行病学和预防，控制和差异）。该中心管理和支持总共12个共享资源，其中4个是最近创建的。

DESCRIPTION (provided by applicant): The Herbert Irving Comprehensive Cancer Center (HICCC) was designated an NCI Cancer Center in 1972 and gained comprehensive status in 1979. The HICCC is a component of Columbia University Medical Center and associated with New York-Presbyterian Hospital (NYPH). During the period 2003-07, CUMC and NYPH have committed over $312.7 million for i) new research initiatives in basic, clinical and population science; ii) new and expanded facilities for laboratory research and clinical activities; iii) recruitment and program restructuring; iv) support of the Center's administrative office; and v) bridge funding to offset reduced NCI CCSG support. A new Director, Riccardo Dalla-Favera, MD, was appointed in 2005 and given: i) authority over new facilities, including the Irving Cancer Research Center (ICRC), a new 10-story building dedicated to cancer research, with state-of-the-art laboratories (100,000 square feet) and incremental clinical (30,000 square feet) space in the Herbert Irving Pavilion (HIP); ii) a broad-based recruitment plan, which has already attracted 8 new faculty members to the HICCC; and iii) restructuring and expansion of the shared resources. The Director has fully reshaped the senior leadership of the HICCC with appointments of a Deputy Director for Clinical Research and Associate Directors for Basic Research, Clinical Research, Population Science, Biomedical Informatics, Shared Resources and Administration. The programmatic structure of the HICCC has been reorganized to increase cancer focus and interdisciplinary collaboration, and now includes 216 members from 22 Departments and 6 Schools, assigned to two Basic Research programs (Cancer Signaling Networks and Cancer Genetics & Epigenetics), three Disease-Specific programs (Breast Cancer, Prostate Cancer, and Lymphoid Development & Malignancy), and two Population Science programs (Cancer Epidemiology and Prevention, Control & Disparities). The HICCC administers and supports a total of 12 Shared Resources, of which four have been recently created.