Case Comprehensive Cancer Center (Case CCC) Cancer Health Disparities SPORE Planning Grant

总体总结/摘要 案例癌症差异 P20 提案规定规划和制定一项专门计划 癌症健康差异方面的卓越研究 (SPORE)。该提案强调冒号 腺瘤、结直肠癌 (CRC) 的前驱病变和乳腺癌是两个主要的癌症 美国癌症死亡原因中，种族差异持续存在且正在扩大。这个 拟议的 P20 计划以凯斯综合癌症中心的资源为基础，提出了两个 使用多层次风险评估方法进行检查的尖端转化研究项目 早期结肠肿瘤发展中的种族差异和表观遗传衰老（项目1）和使用系统 探究三阴性种族差异背后分子机制的生物学方法 乳腺癌 (TNBC) 对治疗和生存的反应（项目 2）。这两个研究项目分别是 建立在大量初步数据、尖端技术和方法的基础上，并支持患者群体 和组织来测试具有高度转化意义的新假设。这个P20计划将进一步发展 一个全面的基础设施，用于促进强大的发展研究计划（DRP）， 我们对其他癌症以及导致癌症的社会经济、人口和行为因素所做的努力 差异。一系列 2 个核心资源支持这些项目，并建立了强大的计划性 癌症健康差异跨学科转化研究的基础设施。该提案带来 一个高度跨学科的研究团队聚集在一起，在每个阶段进行协作， 拟议研究的目的是实现该 P20 应用程序的转化目标。

Overall Summary/Abstract The Case Cancer Disparities P20 proposal provides for planning and development of a Specialized Program of Research Excellence (SPORE) in cancer health disparities. This proposal places an emphasis on colon adenoma, precursor lesion of colorectal cancer (CRC), and on breast cancer, which are the two leading causes of cancer death in the United States, and of which, racial disparities persist and are widening. This proposed P20 program builds on the resources of the Case Comprehensive Cancer Center to propose two cutting edge translational Research Projects that use multi-level risk assessment approaches for examining racial difference and epigenetic aging in the development of early colon neoplasia (Project 1) and use systems biology approaches for interrogating molecular mechanisms underlying racial disparities in triple negative breast cancer (TNBC) response to treatment and survival (Project 2). These two Research Projects each are built upon substantial preliminary data, cutting edge technology and methodology, and enabling patient cohorts and tissues to test novel hypotheses with high translational significance. This P20 program will further develop a comprehensive infrastructure for catalyzing a robust Developmental Research Program (DRP) that extend our efforts to other cancers and socioeconomic, demographic and behavioral factors contributing to cancer disparities. A series of 2 core resources support these projects and also establish a strong programmatic infrastructure for transdisciplinary translational research in cancer health disparities. The proposal brings together a highly transdisciplinary team of investigators that work collaboratively through every stages and aims of the proposed research studies to accomplish the translational goal of this P20 application.