Case Comprehensive Cancer Center (Case CCC) Cancer Health Disparities SPORE Planning Grant

总体摘要/摘要 案例癌症差异P20提案规定了规划和制定一项专门的方案 在癌症健康差异方面的卓越研究(孢子)。这项建议强调冒号 腺瘤，结直肠癌的前驱病变(CRC)和乳腺癌，这是两个主要的 在美国，癌症死亡的原因，其中，种族差异仍然存在，并正在扩大。这 拟议的P20计划以病例综合癌症中心的资源为基础，提出两项 使用多层次风险评估方法的尖端翻译研究项目 种族差异和表观遗传老化在早期结肠肿瘤发生中的作用(项目1)和使用系统 用生物学方法探讨三重阴性的种族差异的分子机制 乳腺癌(TNBC)对治疗和生存的反应(项目2)。这两个研究项目分别是 建立在大量初步数据、尖端技术和方法以及支持患者队列的基础上 和组织来检验具有很高翻译意义的新假说。这个P20计划将进一步发展 全面的基础设施，用于促进可扩展的强大发展研究计划(DRP) 我们对其他癌症的努力以及导致癌症的社会经济、人口和行为因素 差距。一系列2个核心资源支持这些项目，并建立了强大的方案 癌症健康差异跨学科转化性研究的基础设施。这项提议带来了 一支高度跨学科的调查团队，在每个阶段和 建议研究的目的是为了实现本P20应用程序的翻译目标。

Overall Summary/Abstract The Case Cancer Disparities P20 proposal provides for planning and development of a Specialized Program of Research Excellence (SPORE) in cancer health disparities. This proposal places an emphasis on colon adenoma, precursor lesion of colorectal cancer (CRC), and on breast cancer, which are the two leading causes of cancer death in the United States, and of which, racial disparities persist and are widening. This proposed P20 program builds on the resources of the Case Comprehensive Cancer Center to propose two cutting edge translational Research Projects that use multi-level risk assessment approaches for examining racial difference and epigenetic aging in the development of early colon neoplasia (Project 1) and use systems biology approaches for interrogating molecular mechanisms underlying racial disparities in triple negative breast cancer (TNBC) response to treatment and survival (Project 2). These two Research Projects each are built upon substantial preliminary data, cutting edge technology and methodology, and enabling patient cohorts and tissues to test novel hypotheses with high translational significance. This P20 program will further develop a comprehensive infrastructure for catalyzing a robust Developmental Research Program (DRP) that extend our efforts to other cancers and socioeconomic, demographic and behavioral factors contributing to cancer disparities. A series of 2 core resources support these projects and also establish a strong programmatic infrastructure for transdisciplinary translational research in cancer health disparities. The proposal brings together a highly transdisciplinary team of investigators that work collaboratively through every stages and aims of the proposed research studies to accomplish the translational goal of this P20 application.