Case Comprehensive Cancer Center (Case CCC) Cancer Health Disparities SPORE Planning Grant

凯斯综合癌症中心 (Case CCC) 癌症健康差异 SPORE 规划补助金

• 批准号: 10005904
• 负责人: Nathan A. Berger
• 金额: $ 106.9万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-18 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10005904
• 关键词: Acceleration; African American; Age; Aging; American; Behavioral; Biological; Cancer Burden; Cancer Etiology; Cancer Patient; Cessation of life; Colon; Colonic Adenoma; Colonic Neoplasms; Colorectal Cancer; Comprehensive Cancer Center; DNA Methylation; Data; Development; Disease; Epigenetic Process; European; Fostering; Genetic; Goals; Grant; Incidence; Individual; Industrialization; Inflammatory; Infrastructure; Lesion; Life Style; Link; Macrophage Activation; Malignant Neoplasms; Malignant neoplasm of prostate; Mediator of activation protein; Methodology; Molecular; Morbidity - disease rate; Neighborhoods; Outcome; Pathology; Patients; Population; Population Study; Program Research Project Grants; Research; Research Personnel; Research Project Grants; Resources; Risk; Risk Assessment; Risk Factors; Series; Services; Signal Transduction; Specialized Program of Research Excellence; Structure; Systems Biology; Technology; Testing; Tissues; Translational Research; United States; Work; ZNF151 gene; base; cancer health disparity; chemotherapy; cohort; contextual factors; lifestyle factors; macrophage; malignant breast neoplasm; molecular marker; mortality; novel; novel strategies; programs; racial difference; racial disparity; research study; response; socioeconomics; translational scientist; treatment response; triple-negative invasive breast carcinoma; tumor; tumor-immune system interactions

Overall Summary/Abstract The Case Cancer Disparities P20 proposal provides for planning and development of a Specialized Program of Research Excellence (SPORE) in cancer health disparities. This proposal places an emphasis on colon adenoma, precursor lesion of colorectal cancer (CRC), and on breast cancer, which are the two leading causes of cancer death in the United States, and of which, racial disparities persist and are widening. This proposed P20 program builds on the resources of the Case Comprehensive Cancer Center to propose two cutting edge translational Research Projects that use multi-level risk assessment approaches for examining racial difference and epigenetic aging in the development of early colon neoplasia (Project 1) and use systems biology approaches for interrogating molecular mechanisms underlying racial disparities in triple negative breast cancer (TNBC) response to treatment and survival (Project 2). These two Research Projects each are built upon substantial preliminary data, cutting edge technology and methodology, and enabling patient cohorts and tissues to test novel hypotheses with high translational significance. This P20 program will further develop a comprehensive infrastructure for catalyzing a robust Developmental Research Program (DRP) that extend our efforts to other cancers and socioeconomic, demographic and behavioral factors contributing to cancer disparities. A series of 2 core resources support these projects and also establish a strong programmatic infrastructure for transdisciplinary translational research in cancer health disparities. The proposal brings together a highly transdisciplinary team of investigators that work collaboratively through every stages and aims of the proposed research studies to accomplish the translational goal of this P20 application.

摘要/Abstract 病例癌症差异P20提案规定规划和发展一个专业计划， 研究卓越（孢子）在癌症健康差距。这个建议强调冒号 腺瘤，结直肠癌（CRC）的前体病变和乳腺癌，这是两个主要的 在美国，癌症死亡的主要原因是种族差异，种族差异持续存在并正在扩大。这 拟议的P20计划建立在病例综合癌症中心的资源基础上，提出两个 尖端的转化研究项目，使用多层次的风险评估方法， 早期结肠肿瘤形成中的种族差异和表观遗传老化（项目1）和使用系统 三阴性患者种族差异分子机制的生物学研究方法 乳腺癌（TNBC）对治疗的反应和生存率（项目2）。这两个研究项目分别是 基于大量的初步数据、尖端技术和方法， 和组织来测试具有高翻译意义的新假设。P20计划将进一步发展 一个全面的基础设施，用于促进一个强大的发展研究计划（DRP）， 我们对其他癌症的努力以及导致癌症的社会经济，人口统计学和行为因素 差距。一系列的2个核心资源支持这些项目，并建立一个强大的方案， 癌症健康差异的跨学科转化研究的基础设施。该提案带来了 一个高度跨学科的调查团队，在每个阶段都协同工作， 所提出的研究目的是为了实现这一P20应用程序的转化目标。