University of California, Irvine Cancer Center Support Grant

描述（由申请人提供）：加州大学欧文分校综合癌症中心是橙县唯一一个nci指定的综合癌症中心，是一个矩阵型组织。该癌症中心为奥兰治县大约300万人提供服务。癌症中心的研究目标是：1)促进对癌症表型和基因型的基本机制的理解；2)促进实验室和流行病学研究转化为假设驱动的临床预防和治疗研究；3)在可能的情况下，通过本中心的研究开展临床预防试验；4)确定中心服务的不同社会经济和多元文化社会的癌症风险，并制定研究策略，以促进这些人群的癌症预防和早期发现；5)利用各级广泛的教育和培训机会作为主要的转化手段，鼓励促进跨学科、多学科和跨学科研究的活动。

DESCRIPTION (provided by applicant): The University of California, Irvine Comprehensive Cancer Center is the only NCI-designated Comprehensive Cancer Center in Orange County and is a matrix-type organization. The Cancer Center serves approximately three million people in Orange County. The research goals of the Cancer Center are: 1) To contribute to the understanding of basic mechanisms that underlie the phenotype and genotype of cancer; 2) To facilitate the translation of laboratory and epidemiologic research into hypothesis-driven clinical prevention and treatment studies; 3) To conduct clinical prevention trials, whenever possible emanating from research generated in the Center; 4) To define cancer risk in the diverse socioeconomic and multicultural society served by the Center and to develop research strategies to facilitate the prevention and early detection of cancer in these populations; and 5) To utilize the extensive education and training opportunities available at all levels as a major translational vehicle and to encourage activities that promote interdisciplinary, multidisciplinary, and transdisciplinary research. The Center is organized into four major Divisions: Basic Sciences, Clinical Research, Cancer Control & Population Sciences, and Education & Training. The Divisions interact through seven research programs: Carcinogenesis, Developmental Biology, Growth Factors & Signaling, Onco-lmaging & Spectroscopy, Population Sciences, Structural Molecular Biology, and Translational Oncology. The Center provides centralized support for Program functions through ten Shared Resource Facilities: Biobehavioral, Biostatistics, Clinical Research Office, DMA Sequencing, DMA & Protein MicroArray, Experimental Tissue, In-Vivo Functional Onco-lmaging, Optical Biology, Protein Mass Spectrometry, and Transgenic Mouse. The Education & Training Division facilitates integration of students into basic, clinical, and cancer control research activities in the various programs and accordingly enhances the translational capabilities of the Center. The 143 full Members of the Center are currently supported by $11,909,249 in direct NCI funds. Of the overall direct total of cancer-related funding ($36,214,529), $30,665,383 is peer-reviewed and $5,549,146 is non-peer-reviewed. Cancer Center Members entered 202 participants on prevention, therapeutic, and supportive care trials in the 2006-07 reporting year.