University of California, Irvine Cancer Center Support Grant

描述（由申请人提供）：加州大学欧文分校综合癌症中心是橙子县唯一一个NCI指定的综合癌症中心，是一个矩阵型组织。癌症中心为橙子县大约300万人提供服务。癌症中心的研究目标是：1）有助于理解癌症表型和基因型的基本机制; 2）促进实验室和流行病学研究转化为假设驱动的临床预防和治疗研究; 3）尽可能进行临床预防试验，从中心产生的研究中产生; 4）确定癌症的风险在不同的社会经济和多元文化的社会服务中心，并制定研究战略，以促进预防和早期发现癌症在这些人群中;和5）利用所有各级现有的广泛教育和培训机会，作为主要的转化工具，并鼓励开展活动，跨学科、多学科和跨学科研究。 该中心分为四个主要部门：基础科学，临床研究，癌症控制和人口科学以及教育和培训。该部门通过七个研究项目进行互动：致癌作用，发育生物学，生长因子和信号传导，肿瘤成像和光谱学，人口科学，结构分子生物学和转化肿瘤学。该中心通过10个共享资源设施为计划功能提供集中支持：生物行为学，生物统计学，临床研究办公室，DMA测序，DMA和蛋白质微阵列，实验组织，体内功能性肿瘤成像，光学生物学，蛋白质质谱和转基因小鼠。教育和培训部门促进学生融入各种计划中的基础，临床和癌症控制研究活动，并相应地提高中心的翻译能力。 该中心的143名正式成员目前由11，909，249美元的直接NCI资金支持。在与癌症有关的直接供资总额（36 214 529美元）中，30 665 383美元是经过同行审查的，5 549 146美元是未经同行审查的。在2006-07报告年度，癌症中心成员参加了202名参与者的预防、治疗和支持性护理试验。

DESCRIPTION (provided by applicant): The University of California, Irvine Comprehensive Cancer Center is the only NCI-designated Comprehensive Cancer Center in Orange County and is a matrix-type organization. The Cancer Center serves approximately three million people in Orange County. The research goals of the Cancer Center are: 1) To contribute to the understanding of basic mechanisms that underlie the phenotype and genotype of cancer; 2) To facilitate the translation of laboratory and epidemiologic research into hypothesis-driven clinical prevention and treatment studies; 3) To conduct clinical prevention trials, whenever possible emanating from research generated in the Center; 4) To define cancer risk in the diverse socioeconomic and multicultural society served by the Center and to develop research strategies to facilitate the prevention and early detection of cancer in these populations; and 5) To utilize the extensive education and training opportunities available at all levels as a major translational vehicle and to encourage activities that promote interdisciplinary, multidisciplinary, and transdisciplinary research. The Center is organized into four major Divisions: Basic Sciences, Clinical Research, Cancer Control & Population Sciences, and Education & Training. The Divisions interact through seven research programs: Carcinogenesis, Developmental Biology, Growth Factors & Signaling, Onco-lmaging & Spectroscopy, Population Sciences, Structural Molecular Biology, and Translational Oncology. The Center provides centralized support for Program functions through ten Shared Resource Facilities: Biobehavioral, Biostatistics, Clinical Research Office, DMA Sequencing, DMA & Protein MicroArray, Experimental Tissue, In-Vivo Functional Onco-lmaging, Optical Biology, Protein Mass Spectrometry, and Transgenic Mouse. The Education & Training Division facilitates integration of students into basic, clinical, and cancer control research activities in the various programs and accordingly enhances the translational capabilities of the Center. The 143 full Members of the Center are currently supported by $11,909,249 in direct NCI funds. Of the overall direct total of cancer-related funding ($36,214,529), $30,665,383 is peer-reviewed and $5,549,146 is non-peer-reviewed. Cancer Center Members entered 202 participants on prevention, therapeutic, and supportive care trials in the 2006-07 reporting year.