CARCINOGENESIS PROGRAM

致癌（CA）计划的中心主题是研究分子和细胞机制 潜在的癌症发生和发展，目的是将获得的知识应用于诊断， 预防和治疗癌症。重点领域包括DNA损伤反应的各个方面， 致癌作用和癌症建模。 计划成员：在过去六年中，该计划的成员经历了一些变化， 重大变化。这些变化是各种因素造成的。一个因素是， 转移计划成员以帮助现有计划（例如，沃特曼博士成为联合领导人 生长因子和信号计划）或建立新的计划（例如，Nalcioglu博士成为Co- 肿瘤成像和光谱学项目的负责人）。另一个因素是2006年底决定， 解散病毒学计划，并纳入那些从事病毒致癌方面工作的成员 加入致癌计划这些因素，以及其他教师的流动，导致了 增加了17个新的教师，共有28名正式成员。相比之下， 2002年正式成员。目前，成员分布在13个部门的学校， 医学、生物科学和物理科学。癌症中心大力支持 在过去的一段时间里，我们招募了几名新成员。其中包括汉斯-乌尔里希·伯纳德、伊娃 作者声明：John W.应指出，两名成员Ingrid Ruf和Dominik Wodarz， 通过由主校区提供给癌症中心的FTE招募到UCI。于最近的一个 招募的是谢尔盖·格兰多，一位资深的、资金充足的调查员，他带来了亚硝胺引发的 致癌作用 CA计划有28名成员，代表12个部门和3所学校，并有5，910，891美元， 直接与癌症相关的同行评审资金，其中10个项目由NCI资助，直接总额为 3025379美元在2007年，委员共出版了74份刊物，其中48份与癌症有关， 其中25%为内部相关，8%为内部相关。

The central theme of the Carcinogensis (CA) Program is to investigate molecular and cellular mechanisms underlying cancer initiation and progression, with the goal of applying the knowledge gained to the diagnosis, prevention, and treatment of cancer. Focus areas include various aspects of DNA damage response, viral carcinogenesis, and cancer modeling. Program Membership: During the past six years, the membership of this Program has undergone some significant changes. These changes have been the consequence of a variety of factors. One factor was the transfer of Program Members to either aid existing Programs (e.g., Dr. Waterman to become Co-Leader of the Growth Factors & Signaling Program) or establish new Programs (e.g., Dr. Nalcioglu to become Co- Leader of the Onco-lmaging & Spectroscopy Program). Another factor was the decision in late 2006 to disband the Virology Program and incorporate those members working on aspects of viral carcinogenesis into the Carcinogenesis Program. These factors, as well as other faculty turnover, have resulted in the addition of 17 new faculty for a total Membership of 28 full Members. This compares to a membership of 20 full Members in 2002. Currently, the membership is spread over 13 Departments within the Schools of Medicine, Biological Sciences, and Physical Sciences. The Cancer Center has significantly supported the recruitment of several new Members over the past funding period. These include Hans-Ulrich Bernard, Eva Lee, and Dominik Wodarz. It is to be noted that two Members, Ingrid Ruf and Dominik Wodarz, were recruited to UCI through FTEs that were provided to the Cancer Center by the main campus. A very recent recruit is Sergei Grando, a senior and well-funded investigator who brings expertise in nitrosamine-initiated carcinogenesis. The CA Program has 28 Members representing 12 Departments and three Schools, and has $5,910,891 in direct cancer-related peer-reviewed funding, 10 projects of which are funded by NCI for a direct total of $3,025,379. In 2007, Members published a total of 74 publications with 48 of those being cancer-related of which 25% were inter- and 8% were intra-related.