STRUCTURAL MOLECULAR BIOLOGY PROGRAM

结构分子生物学课程

• 批准号: 7944517
• 负责人: FRANK L. MEYSKENS
• 金额: $ 1.49万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-06 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7944517
• 关键词: Active Sites; Affect; Amino Acids; Antibodies; Architecture; Area; Atomic Force Microscopy; Biochemical; Cancer Center; Cancer Center Support Grant; Characteristics; Chemicals; Drug Delivery Systems; Electron Microscopy; Enzymes; Funding; Goals; Heart; Lead; Ligand Binding; Malignant Neoplasms; Mass Spectrum Analysis; Methods; Modification; Molecular; Molecular Biology; Mutation; Oncogenic Viruses; Peer Review; Pharmaceutical Preparations; Pharmacology; Process; Protein Conformation; Publications; Publishing; Schools; Scientist; Side; Structure; System; Technology; Therapeutic Agents; University of California Irvine Cancer Center; X-Ray Crystallography; base; cancer therapy; design; member; microbial; novel; novel diagnostics; programs; protein structure; response

The central theme of the Structural Molecular Biology (SM) Program is to utilize the modern methods of chemical and biochemical structural analysis to important cancer-related problems, as well as in using the structural information to direct the synthesis of novel chemotherapeutics. This perspective is especially important in translational areas in which molecular aspects of the cancer-promoting process are known. The immediate goals of the SM Program are to identify useful systems that might ultimately lead to advances in cancer treatment, and to analyze them using the range of technologies available. This means deducing the arrangement of amino acid side chains in the active sites of enzymes, following the dynamics of protein conformation in response to ligand binding, delineating the crucial characteristics necessary for the design of antibody-based drugs, or describing the architectures on which oncogenic viruses are founded. Function follows from structure, and modification of function lies at the heart of therapy. The SM Program has 19 Members, representing six Departments and five Schools, and has $2,615,535 in direct cancer-related peer-reviewed funding, one project of which is funded by NCI for a direct total of $249,099. In 2007, Members published a total of 55 publications with 24 of those being cancer-related of which 33% were inter- and 8% were intra-related.

结构分子生物学（SM）计划的中心主题是利用现代方法， 化学和生物化学结构分析的重要癌症相关的问题，以及在使用 结构信息来指导新型化学治疗剂的合成。这种观点尤其 在促癌过程的分子方面已知的翻译领域很重要。的 “战略管理计划”的近期目标是确定一些有用的系统，这些系统最终可能会导致以下方面的进步： 癌症治疗，并使用各种可用技术对其进行分析。这意味着推断出 氨基酸侧链在酶活性位点的排列，遵循蛋白质的动力学 构象响应配体结合，描绘了设计所需的关键特征， 基于抗体的药物，或描述致癌病毒的结构。功能 从结构出发，功能的改变是治疗的核心。 SM计划有19名成员，代表六个部门和五所学校，并有2，615，535美元， 直接与癌症相关的同行评审资助，其中一个项目由NCI资助，直接总额为 二十四万九千零九十九美元2007年，委员共出版了55份刊物，其中24份与癌症有关， 其中33%为内部相关，8%为内部相关。