POPULATION SCIENCES PROGRAM

人口科学项目

• 批准号: 7944537
• 负责人: FRANK L. MEYSKENS
• 金额: $ 2.04万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-06 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7944537
• 关键词: Affect; Arginine; Behavioral; Cancer Center Support Grant; Cancer Control; Cancer Etiology; Cessation of life; Chemoprevention; Chemopreventive Agent; Clinical; Colorectal Adenoma; Colorectal Cancer; Continuance of life; DL-alpha-Difluoromethylornithine; Data; Diet; Disease; Erlotinib; Funding; Future; Genetic; Goals; Head; Hereditary Breast and Ovarian Cancer Syndrome; Hispanics; Incidence; Individual; Knowledge; Life Style; Malignant - descriptor; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Malignant neoplasm of pancreas; Measures; Metastatic to; Methodology; Modification; Molecular Genetics; Morbidity - disease rate; Organ; Outcome; Participant; Patients; Peer Review; Pharmacogenetics; Phase; Phase III Clinical Trials; Pilot Projects; Population; Population Heterogeneity; Population Sciences; Predisposition; Premalignant; Prevention; Process; Publications; Publishing; Quality of Care; Quality of life; Randomized; Recurrence; Research; Risk; Schools; Secondary Prevention; Serological; Site; Sulindac; Testing; Therapeutic; Translating; Translations; University of California Irvine Cancer Center; Woman; adenoma; cancer prevention; cancer risk; cancer site; design; epidemiology study; follow-up; genetic epidemiology; genetic risk factor; health disparity; high risk; lifestyle factors; malignant breast neoplasm; member; mortality; outreach; outreach program; prevent; programs; psychosocial; survivorship; tumor progression

The Population Sciences Research Program (led by H. Anton-Culver and S. Neuhausen) is composed of three themes, Genetic Epidemiology (headed by S. Neuhausen), Prevention (headed by S. Lipkin), and Outreach and Cancer Control (headed by L. Wenzel). The Program is focused on investigating the continuum of cancer from normal to pre-malignant to malignant to metastatic disease. There are interactions and interplay among the three themes within cancer sites and across the continuum. The main objectives of the research are to build on current knowledge and to create new paradigms to understand: a) how cancers develop in susceptible populations; b) how to prevent cancer from developing; c) how cancers progress; and d) how to reduce morbidity and mortality from cancer. This research program is focused on organ-specific sites. Methodologies and approaches that are developed in one cancer are translated into other cancers. In the Genetic Epidemiology theme, breast cancer is a primary focus. There are five on-going studies to investigate genetic and lifestyle factors associated with risk of breast cancer. The identification of lifestyle and genetic factors that contribute to breast cancer risk is crucial to design both preventative and therapeutic strategies and to identify at risk individuals, in order to reduce the incidence of and death from this disease. In the Prevention theme, the focus is on chemoprevention. One of the most successful chemoprevention trials for secondary prevention of colorectal cancer is the randomized phase III study of Sulindac plus Difluoromethylornithine (DFMO) in Reducing Recurrent Colorectal Adenomas. Overall a highly significant reduction of 70% of all adenomas was achieved in those receiving DFMO/Sulindac (P<0.001). Advanced adenomas were reduced by 90% (P=0.001). In the Outreach and Cancer Control theme, a major focus is cervical cancer disease processes at the phase between susceptibility and pre-malignancy and after suspicion of a pre-malignancy in a high risk group of Hispanic women. Factors that influence survivorship after the malignancy has been treated are being identified to aid in cancer control and potentially prevent metastatic disease. Future emphases of the Population Sciences Program include quantitative assessment of factors that affect cancer etiology, progression and outcome to generate clues for cancer prevention targets. We will continue to focus on health disparities as they modify risk and outcome of cancer. The PS Program has 13 Members, representing four Departments and two Schools, and has $3,031,090 in direct cancer-related peer-reviewed funding, 11 projects of which are funded by NCI for a direct total of $2,382,560. In 2007, Members published a total of 60 publications with 45 of those being cancer-related of which 36% were inter- and 33% were intra-related.

人口科学研究计划(由H.Anton-Culver和S.Neuhausen领导)由以下几个部分组成 三个主题，遗传流行病学(由S.Neuhausen领导)、预防(由S.Lipkin领导)和 外展和癌症控制(由L.Wenzel领导)。该计划的重点是调查 癌症从正常到癌前、恶性到转移性疾病的连续过程。有一些互动 以及三个主题在癌症部位内和整个连续体之间的相互作用。的主要目标 这项研究是建立在现有知识的基础上，并创造新的范式来理解：a)癌症是如何 在易感人群中发展；b)如何预防癌症发展；c)癌症如何发展；以及 D)如何降低癌症的发病率和死亡率。这项研究计划的重点是特定的器官 网站。在一种癌症中开发的方法和方法也会转化为其他癌症。在……里面 遗传流行病学的主题是，乳腺癌是主要的焦点。有五项正在进行的研究 调查与乳腺癌风险相关的遗传和生活方式因素。对生活方式的认同 而导致乳腺癌风险的遗传因素对于预防和治疗都是至关重要的。 为了减少这一疾病的发病率和死亡率，有必要制定战略并确定高危人群。 在预防主题中，重点是化学预防。最成功的化学预防措施之一 关于结直肠癌二级预防的试验是舒林酸加的随机III期研究 二氟甲基鸟氨酸(DFMO)减少复发性结直肠腺瘤总体而言，一个非常重要的 在接受DFMO/舒林酸治疗的患者中，腺瘤减少了70%(P&lt；0.001)。进阶 腺瘤减少90%(P=0.001)。在外联和癌症控制主题中，一个主要重点是 宫颈癌疾病在易感、恶变前和恶变后的过程 怀疑西班牙裔女性高危人群有癌前病变。影响生存的因素 在恶性肿瘤被治疗后，被发现有助于癌症控制和潜在的预防 转移性疾病。人口科学计划的未来重点包括定量评估 分析影响癌症病因、进展和转归的因素，为癌症预防提供线索 目标。我们将继续关注健康差异，因为它们改变了癌症的风险和结果。 PS计划有13名成员，代表四个部门和两所学校，在#年有3031,090美元 与癌症相关的直接同行审查资助，其中11个项目由NCI资助，直接总数为 2382,560美元。在2007年，会员共出版了60本刊物，其中45本与癌症有关。 其中36%是内部关系，33%是内部关系。