Cancer Center Support Grant

描述(由申请人提供)：科罗拉多大学癌症中心(UCCC)是落基山地区唯一由NCI指定的综合性癌症中心，该地区约有800万人口。其目标是通过以下方式减轻癌症负担：1)开展协调和跨学科的基础、临床、翻译、预防和控制、人口和教育研究；2)为科罗拉多州和落基山地区的公民提供最先进的癌症研究、治疗、早期发现、预防和控制项目；3)从学生到公共部门提供各级癌症教育。UCCC共有271名正式成员和110名准成员，他们参加了UCCC的八个项目中的一个或多个，包括癌症细胞生物学、分子和结构生物学、免疫学和免疫疗法、激素相关恶性肿瘤、烟草相关恶性肿瘤、发育治疗学、癌症发生和化学预防以及临床和社区癌症预防和控制。在过去的五年里，NCI赞助的研究投资组合几乎翻了一番，从2100万美元增加到3970万美元，其中不包括CCSG。这在很大程度上是通过成功地资助每年总额超过700万美元的主要新合作NCI赠款和合同，以及通过招募100名持有NCI赠款支持超过1400万美元的新成员来实现的。在过去的五年中，临床试验的受试者数量和门诊就诊次数也翻了一番。癌症中心是科罗拉多大学丹佛大学和健康科学中心内的一个“矩阵”癌症中心，我们作为一个联合体提出申请，成员来自科罗拉多大学博尔德校区、AMC癌症研究中心、国家犹太医学和研究中心以及科罗拉多州立大学校园。这些联盟成员加强和扩大癌症研究活动。成员研究得到15个共享核心资源的支持，其中信息学共享资源和结构生物学共享资源是新的。大多数共享资源都增加了重大新服务和设备。中心成员还受益于癌症中心的发展活动，这些活动带来了新的招聘、试点项目和共享设施。规划和评估工作使我们得以搬到菲茨西蒙斯的新校区，提供最先进的设施和更多的合作。新校区的建成将使新校区在未来五年继续增长。

DESCRIPTION (provided by applicant): The University of Colorado Cancer Center (UCCC) is the only NCI-designated comprehensive Cancer Center in the Rocky Mountain region - an area with a population of approximately eight million people. The goals are to reduce the cancer burden by: 1) conducting coordinated and interdisciplinary basic, clinical, translation, prevention and control, population, and educational research, 2) providing citizens of Colorado and the Rocky Mountain region with state-of-the art programs in cancer research, therapy, early detection, prevention and control, and 3) providing cancer education at all levels from students to the public sector. There are 271 full and 110 associate members who participate in one or more of the UCCC's eight programs including Cancer Cell Biology, Molecular and Structural Biology, Immunology and Immunotherapy, Hormone Related Malignancies, Tobacco Related Malignancies, Developmental Therapeutics, Carcinogenesis and Chemoprevention, and Clinical and Community Cancer Prevention and Control. Over the past five years, the NCI sponsored research portfolio has nearly doubled from $21 million to $39.7 million, excluding the CCSG. This was accomplished largely through the successful funding of major new collaborative NCI grants and contracts totaling more than $7 million annually and through the recruitment of 100 new members who hold more than $14 million in NCI grant support. Over the past five years, the number of subjects accrued to clinical trials and the number of outpatient visits have also doubled. The Cancer Center is a "matrix" Cancer Center within the University of Colorado Denver and Health Sciences Center and we are applying as a consortium with members from the University of Colorado at Boulder campus, the AMC Cancer Research Center, the National Jewish Medical and Research Center, and the Colorado State University campuses. These consortium members strengthen and broaden cancer research activities. Member research is supported by 15 shared core resources, of which the Informatics shared resource and the Structural Biology shared resource are new. Major new services and equipment were added to most of the shared resources. Center members also benefit from the Development activities of the Cancer Center that bring new recruitments, pilot projects and shared facilities. Planning and evaluation efforts have allowed our on-going move to the new Fitzsimons campus to provide state-of-the art facilities and increased collaborations. The completion of the new campus will allow continued growth over the next five years.