BioinformatJCS Core
BioinformatJCS Core
批准号:
7620689
负责人:
Jonathan V. Sweedler
金额:
$30.53万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-06-01 至 2014-05-31
关键词:
AddressArtsBioinformaticsBrainCharacteristicsCodeCommunitiesComplexComputer SimulationComputer softwareDataData AnalysesData SetDatabasesDevelopmentExperimental DesignsFundingGeneticGenomeGoalsGunsHormonesInternetLaboratoriesLeadLinkMass Spectrum AnalysisMeasurementMethodsMissionModelingNeuronsNeuropeptidesNeurosciencesOnline SystemsPeptide Signal SequencesPeptidesPost-Translational Protein ProcessingProcessProgress ReportsProteinsProteomicsPublicationsReadingResearchResearch PersonnelResourcesSamplingShotgunsSignaling MoleculeSystemWorkcytokinedata managementintercellular communicationnovel strategiesprogramsprohormoneresearch studysuccesstool
中文摘要
生物信息学核心将通过提供定制实验室与主要用户密切合作
英文摘要
The Bioinformatics Core will work closely with the major users by providing a customized laboratory
sample tracking system, an efficient and quick data pipeline, a tailored project management system,
and a web portal to facilitate sharing of experimental results. The Core will convert the data
acquired from a range of mass spectrometric platforms into qualitative and quantitative information
to address the questions posed by our users. Besides facilitating the analysis of the data for the
users using a range of commercial software, several new bioinformatics tools will be created to
benefit both local users and the broader neuroscience communities. We will continue the
development of NeuroPred, a currently available web-based tool that predicts prohormone
cleavages and the resulting signaling peptides. This predictor provides a valuable link between
genetic information coding for the protein prohormones and the peptide products one observes.
NeuroProSightPTM is another important bioinformatics tool that identifies post-translational
modifications in intact proteins from "top-down" data analysis of absolute masses. The top-down
approach will enable investigators to use absolute masses of intact proteins to identify
neuropeptides, cytokines, hormones, and other neuron-specific proteins and peptides. Lastly, a
unique method of shot-gun peptidomics that combines bioinformatics tools and high accuracy mass
measurements will enhance peptide characterization and identification, and will be used across a
range of important neuroscience models. Together, the well-planned experiments, existing tools,
and new bioinformatics capabilities will create novel approaches and new data on the intercellular
signaling molecules found in the brain.
期刊论文(0)
专著(0)
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会议论文
BI tims TOF fleX with MALDI-2 mass spectrometer
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批准号:10630721
-
项目类别:
-
资助金额:$125.0万
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财政年份:2023
-
负责人:Jonathan V. Sweedler
-
依托单位:
BRAIN Initiative: Integrated Multimodal Analysis of Cell and Circuit-Specific Processes in Hippocampal Function
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批准号:9294862
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项目类别:
-
资助金额:$59.44万
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财政年份:2015
-
负责人:Jonathan V. Sweedler
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依托单位:
Sampling and Separation Core
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批准号:7620681
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项目类别:
-
资助金额:$24.17万
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财政年份:2009
-
负责人:Jonathan V. Sweedler
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依托单位:
Administrative Core
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批准号:7620668
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项目类别:
-
资助金额:$10.27万
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财政年份:2009
-
负责人:Jonathan V. Sweedler
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依托单位:
Protein Identification Core
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批准号:7620687
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项目类别:
-
资助金额:$41.36万
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财政年份:2009
-
负责人:Jonathan V. Sweedler
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依托单位:
ADMINISTRATIVE CORE
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批准号:7700098
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项目类别:
-
资助金额:$17.97万
-
财政年份:2008
-
负责人:Jonathan V. Sweedler
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依托单位:
The Neurometabolome of a Sensory Neuronal Network
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批准号:7303676
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项目类别:
-
资助金额:$35.65万
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财政年份:2007
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负责人:Jonathan V. Sweedler
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依托单位:
The Neurometabolome of a Sensory Neuronal Network
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批准号:7483119
-
项目类别:
-
资助金额:$32.49万
-
财政年份:2007
-
负责人:Jonathan V. Sweedler
-
依托单位:
The Neurometabolome of a Sensory Neuronal Network
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批准号:7643343
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项目类别:
-
资助金额:$32.71万
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财政年份:2007
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负责人:Jonathan V. Sweedler
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依托单位:
The Neurometabolome of a Sensory Neuronal Network
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批准号:7878517
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项目类别:
-
资助金额:$32.34万
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财政年份:2007
-
负责人:Jonathan V. Sweedler
-
依托单位:
The Neurometabolome of a Sensory Neuronal Network
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批准号:8099486
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项目类别:
-
资助金额:$31.33万
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财政年份:2007
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负责人:Jonathan V. Sweedler
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依托单位:
NEUROPEPTIDES IN THE CNS WITH IMAGING MASS SPECTROMETRY
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批准号:7271318
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项目类别:
-
资助金额:$21.64万
-
财政年份:2006
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负责人:Jonathan V. Sweedler
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依托单位:
NEUROPEPTIDES IN THE CNS WITH NEW MASS SPECTROMETRIC SAMPLING PROTOCOLS
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批准号:7100438
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项目类别:
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资助金额:$26.06万
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财政年份:2006
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负责人:Jonathan V. Sweedler
-
依托单位:
Neuropeptides in the CNS with New Mass Spectrometric Sampling Protocols
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批准号:7618153
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项目类别:
-
资助金额:$21.17万
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财政年份:2006
-
负责人:Jonathan V. Sweedler
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依托单位:
NEUROPEPTIDES IN THE CNS WITH IMAGING MASS SPECTROMETRY
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批准号:7426954
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项目类别:
-
资助金额:$21.19万
-
财政年份:2006
-
负责人:Jonathan V. Sweedler
-
依托单位:
NEUROPEPTIDES IN THE CNS WITH NEW MASS SPECTROMETRIC SAMPLING PROTOCOLS
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批准号:7816738
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项目类别:
-
资助金额:$20.94万
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财政年份:2006
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负责人:Jonathan V. Sweedler
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依托单位:
TECHNOLOGIES FOR CELLULAR NEUROMETABOLOMICS
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批准号:7107125
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项目类别:
-
资助金额:$36.7万
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财政年份:2004
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负责人:Jonathan V. Sweedler
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依托单位:
TECHNOLOGIES FOR CELLULAR NEUROMETABOLOMICS(RMI)
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批准号:6952272
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项目类别:
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资助金额:$36.1万
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财政年份:2004
-
负责人:Jonathan V. Sweedler
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依托单位:
ABI 3730 CAPILLARY SEQUENCERS: GENETICS, GENE THERAPY, NEUROGENOMICS
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批准号:6973682
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项目类别:
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资助金额:$5.0万
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财政年份:2004
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负责人:Jonathan V. Sweedler
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依托单位:
ABI 3730 Capillary Sequencers
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批准号:6730965
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项目类别:
-
资助金额:$25.0万
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财政年份:2004
-
负责人:Jonathan V. Sweedler
-
依托单位:
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