Carcinogenesis & Chemoprevention

8.2.1摘要：致癌和化学预防 由斯蒂芬·赫克特博士领导的癌症发生和化学预防计划有22名成员 代表11个部门和7所学校和研究所。截至2007年9月30日，这些成员 为本预算期提供总计940万美元的同行评议资助的研究项目。自.以来 2003年6月，他们的研究产生了476份出版物，其中20%是方案内出版物，15%是方案内出版物 是跨程序的。癌症发生和化学预防计划的研究目标是 阐明癌症发生的机制，并利用这些知识开发和评估治疗癌症的方法 癌症预防。该计划有三个主要的综合广泛的研究主题：烟草和癌症， 致癌机制和化学预防。该计划以翻译活动为特色， 将实验室结果用于临床和流行病学研究，然后利用实验室研究进一步 解读并提炼相关假设。该计划具有高度协作的环境，在 这些成员共享研究方法、知识、方法和试剂。这些互动是 由几个实验室的实际位置以及每月一系列研讨会提供便利，该系列研讨会已经 自1998年以来一直是连续的。烟草与癌症主题以国际公认的 烟草致癌机制的合作小组研究和较强的项目间合作 通过明尼苏达大学跨学科烟草使用研究中心的合作， 特别是在烟草致癌生物标记物的应用领域。致癌机制的研究进展 Theme展示了化学机制和信号领域的极高生产率 癌变过程中的转导途径。化学预防主题，从一个漫长的历史演变而来 明尼苏达大学继续发现和开发治疗呼吸系统癌症的有效药物 尿道癌以及其他癌症。这些临床前研究成果已被转化为新资助的第二阶段。 在这个项目中开发的试剂的研究。程序性交互、共享资源的使用、教师 招募、试点项目和配套资金是癌症中心显著 加强这一项目的研究。

8.2.1 ABSTRACT: CARCINOGENESIS AND CHEMOPREVENTION The Garcinogenesis and Chemoprevention program, lead by Stephen Hecht, Ph.D., has 22 members representing 11 departments and seven schools and institutes. As of September 30, 2007, these members lave a total of $9.4 million in peer-reviewed, funded research projects for the current budget period. Since June 2003, their research has resulted in 476 publications, of which 20% were intra-programmatic and 15% were inter-programmatic. The goal of research in the Carcinogenesis and Chemoprevention Program is to elucidate mechanisms of carcinogenesis and to use this knowledge to develop and evaluate approaches to cancer prevention. The Program has three major integrated broad research themes; tobacco and cancer, mechanisms of carcinogenesis, and Chemoprevention. The program features translational activities which take laboratory findings to clinical and epidemiologic studies, and then uses laboratory studies to further interpret and refine the relevant hypotheses. The program features a highly collaborative environment, in which members share research approaches, knowledge, methods, and reagents. These interactions are facilitated by the physical proximity of several laboratories as well as by a monthly seminar series which has been continuous since 1998. The tobacco and cancer theme features an internationally recognized collaborative group studying mechanisms of tobacco carcinogenesis and strong inter-programmatic collaborations through the University of Minnesota Transdisciplinary Tobacco Use Research Center, particularly in the area of application of tobacco carcinogen biomarkers. The mechanisms of carcinogenesis theme demonstrates exceptionally high productivity in the areas of chemical mechanisms and signal transduction pathways in carcinogenesis. The Chemoprevention theme, evolving from a long history at the University of Minnesota, continues to discover and develop effective agents for cancers of the respiratory tract as well as other cancers. These preclinical findings have been translated into newly funded phase II studies of agents developed in this program. Programmatic interactions, the use of shared resources, faculty recruitment, pilot projects, and matching funds are some of the ways in which the Cancer Center significantly enhances research in this program.