Core A - Administrative Core

摘要 行政核心负责指导本计划项目拨款中的所有活动。以下是 行政核心的具体职责是： O监督方案项目赠款的所有活动和合作 O召开指导委员会每月会议 O召开定期方案项目调查员会议 O召开外部咨询委员会和内部咨询委员会会议 O汇编和总结所有会议的结果，并将报告分发给项目 项目调查员 O准备提交给国家癌症研究所的年度进展报告 O安排出差参加3个方案项目地点的会议 O处理所有计划项目相关费用的报销 O协助方案项目调查员之间的沟通，并编写报告和 稿件 O与国家癌症研究所项目主任和相关人员进行沟通和讨论 官员们 O遵守所有大学、国立卫生研究院和政府的法规和要求 O维持财政和预算职能 O与生物统计核心协调数据质量保证事项 O与共济会癌症分析中心的质谱学实验室协调 生物化学共享资源 指导委员会由每个项目和核心的首席调查员和联合调查员组成。 外部和内部咨询委员会由杰出的科学家组成，他们以其 在与本计划项目拨款目标高度相关的领域内的杰出工作。行政核心 将为本计划项目赠款的所有活动提供专业协调和监督，以确保 在保持高水平沟通的同时，朝着我们的研究目标顺利地合作进展 在我们的调查人员和顾问以及国家癌症研究所之间，确保遵守所有 规章制度，并根据需要与所有相关大学设施、系和研究所合作 为及时完成我们的研究工作。 关联性。肺癌是美国和世界范围内癌症死亡的主要原因。香烟 在美国，大约90%的肺癌死亡是由吸烟引起的。该计划项目拨款使用州- 最先进的遗传学、表观遗传学、分析化学和生化技术，以调查已建立的 吸烟者肺癌易感性的种族差异因此揭示了关键的机制途径 为肺癌预防提供了新的见解。

ABSTRACT The Administrative Core is responsible for direction of all activities in this Program Project Grant. The following are the specific responsibilities of the Administrative Core: o Oversight of all activities and collaborations of the Program Project Grant o Convening monthly meetings of the Steering Committee o Convening regular Program Project Investigators meetings o Convening meetings of the External Advisory Committee and Internal Advisory Committee o Compiling and summarizing the results of all meetings and distributing the reports to Program Project investigators o Preparing annual Progress Reports to the National Cancer Institute o Arranging travel to meetings at the 3 program project sites o Processing reimbursement for all program project-related expenses o Assisting in communication among Program Project investigators and preparation of reports and manuscripts o Communication and discussions with the National Cancer Institute program director and related officials o Compliance with all university, NIH, and governmental regulations and requirements o Maintenance of fiscal and budgetary functions o Coordination of data quality assurance matters in conjunction with the Biostatistics Core o Coordination with the mass spectrometry laboratory of the Masonic Cancer Center Analytical Biochemistry Shared Resource The Steering Committee consists of the Principal Investigators and Co-Investigators of each Project and Core. The External and Internal Advisory Committees consist of distinguished scientists who are well known for their outstanding work in areas highly relevant to the goals of this program project grant. The Administrative Core will provide professional coordination and oversight to all activities of this Program Project grant to ensure smooth collaborative progress toward our research goals while maintaining a high level of communication among our investigators and advisors and the National Cancer Institute, ensuring compliance with all regulations, and working together with all relevant university facilities, departments, and institutes as required for the timely completion of our research. RELEVANCE. Lung cancer is the leading cause of cancer death in the U.S. and worldwide. Cigarette smoking causes approximately 90% of lung cancer mortality in the U.S. This program project grant uses state- of-the-art genetic, epigenetic, analytical chemistry, and biochemical techniques to investigate established ethnic differences in lung cancer susceptibility among smokers to uncover critical mechanistic pathways thus providing new insights for lung cancer prevention.