OPTICAL BIOLOGY (SHARED RESOURCE)

光生物学（共享资源）

• 批准号: 7944544
• 负责人: J LAWRENCE MARSH
• 金额: $ 5.22万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-06 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7944544
• 关键词: Appointment; Basic Science; Biology; Cancer Center; Cancer Center Support Grant; Cell Separation; Cellular Structures; Cellular biology; Clinical; Clinical Medicine; Clinical Research; Clinical Sciences; Complex; Confocal Microscopy; Consult; Cytometry; Development; Developmental Biology; Diagnostic; Equipment; Experimental Designs; Fluorescent Probes; Fostering; Human Resources; Imaging Techniques; Immunology; Institutes; Instruction; Laboratories; Lasers; Optical Methods; Optics; Research Personnel; Research Project Grants; Resource Sharing; Resources; Services; Stem Cell Research; Techniques; Technology; Therapeutic; Time; Tissues; Translating; University of California Irvine Cancer Center; biological systems; driving force; instrumentation; member; new technology; novel; programs

Improvements in optical techniques - laser applications, video and confocal microscopy, cell sorting and analysis, the development of fluorescent probes and the development of quantitative, dynamic and time resolved imaging techniques- are revolutionizing cell biology and are now being translated into the practice of clinical medicine. The primary objective of the Optical Biology Shared Resource is to support all Basic Science and Clinical Research projects that can benefit from access to instrumentation and expertise in optical methods. Optical techniques are broadly classified in terms of diagnostics and therapeutics, and relevant biological systems range from sub cellular structures to tissues. To utilize the unique core technologies effectively, the Shared Resource has been divided into two fundamental components, Service and Development. The service component has been extended by partnerships between the Developmental Biology Center, the Stem Cell Research Center, the Laboratory for Fluoresence Dynamics (LFD) and the newly organized Center for Complex Biosystems. The development component especially for diagnostics and basic subcellular applications has been dramatically enhanced by the appointment of a new facility manager (Dr. Michelle Digman) in partnership with the DEC and LFD and by the recent acquisition of new equipment through a partnership with the CCBS. The development of clinical diagnostics and therapeutics is strongly enhanced through the continuing partnership with the Beckman Laser Institute. A recent partnership with the Center for Immunology has expanded the instrumentation and expertise available for cytometry needs. The benefits to Cancer Center members are highly leveraged through these partnerships. Technical instruction, service and support are provided by three Shared Resource facilities and personnel namely, the OBC, the BLI and the Cytometry facility. The Shared Resource Director and co-Coordinators consult on initial experimental design and matching investigators with the proper facility and collaborator. Since a primary driving force behind optical biology is the development of new technology, the second component of the Shared Resource encourages development and utilization of novel optical methods in the basic science and clinical science programs. This is fostered by collaborative efforts between M. Digman and the LFD or T. Krasieva and the BLI.

光学技术的改进-激光应用、视频和共聚焦显微镜、细胞分选和 分析，荧光探针的发展和定量，动态和时间的发展 分辨成像技术-正在彻底改变细胞生物学，现在正在转化为实践， 临床医学。光学生物学共享资源的主要目标是支持所有基础 科学和临床研究项目，可以受益于获得仪器和专业知识， 光学方法光学技术在诊断和治疗方面被广泛分类， 相关的生物系统的范围从亚细胞结构到组织。利用独特的核心 技术有效地，共享资源已被分为两个基本组成部分，服务 发展先行者的要求服务部分已通过与发展中国家之间的伙伴关系得到扩展， 生物中心、干细胞研究中心、遗传动力学实验室（LFD）和 新成立的复杂生物系统中心。开发组件，尤其是诊断组件 和基本的亚细胞应用已经大大加强了任命一个新的设施， 经理（米歇尔迪格曼博士）与DEC和LFD合作，并通过最近收购新的 通过与CCBS的合作伙伴关系，临床诊断学和治疗学的发展是 通过与贝克曼激光研究所的持续合作，我们的产品得到了极大的提升。最近的一 与免疫学中心的合作扩大了仪器和专业知识， 细胞计数需要。癌症中心成员的利益通过这些伙伴关系得到高度利用。 技术指导、服务和支持由三个共享资源设施和人员提供 即OBC、BLI和细胞计数设施。共享资源主任和联合协调员 就初步实验设计以及将研究人员与适当的设施和合作者进行匹配提供咨询。 由于光学生物学背后的主要驱动力是新技术的发展， 共享资源的组成部分鼓励开发和利用新的光学方法， 基础科学和临床科学课程。这是由M.迪格曼 和LFD或T. Krasieva和BLI。