OPTICAL BIOLOGY (SHARED RESOURCE)

改进光学技术--激光应用、视频和共聚焦显微镜、细胞分选和 分析、荧光探针的发展以及定量、动态和时间的发展 分辨率成像技术正在给细胞生物学带来革命性的变化，现在正在转化为实践 临床医学。光生物学共享资源的首要目标是支持所有基本的 科学和临床研究项目可受益于以下领域的仪器和专业知识 光学方法。光学技术在诊断和治疗方面被广泛分类，以及 相关的生物系统范围从亚细胞结构到组织。利用独特的核心 技术有效地将共享资源划分为两个基本组件：服务 和发展。服务部分已通过发展伙伴关系得到扩展 生物中心、干细胞研究中心、荧光动力学实验室和 新成立的复杂生物系统中心。专门用于诊断的开发组件 通过指定一个新的设施，基本的亚蜂窝应用得到了极大的增强 经理(米歇尔·迪格曼博士)与DEC和LFD合作，最近收购了新的 通过与CCBS的伙伴关系提供设备。临床诊断和治疗学的发展是 通过与贝克曼激光研究所的持续伙伴关系，得到了强有力的加强。最近 与免疫学中心的伙伴关系扩大了可用的仪器和专业知识 细胞学需要。通过这些伙伴关系，癌症中心成员的利益得到了高度的利用。 技术指导、服务和支持由三个共享资源设施和人员提供 即OBC、BLI和细胞学设施。共享资源主任和联合协调人 就初始实验设计进行咨询，并将调查人员与适当的设施和合作者进行匹配。 由于光学生物学背后的主要驱动力是新技术的发展，第二 共享资源的组成部分鼓励开发和使用新的光学方法 基础科学和临床科学计划。这是由M·迪格曼 以及LFD或T.Krasieva和BLI。

Improvements in optical techniques - laser applications, video and confocal microscopy, cell sorting and analysis, the development of fluorescent probes and the development of quantitative, dynamic and time resolved imaging techniques- are revolutionizing cell biology and are now being translated into the practice of clinical medicine. The primary objective of the Optical Biology Shared Resource is to support all Basic Science and Clinical Research projects that can benefit from access to instrumentation and expertise in optical methods. Optical techniques are broadly classified in terms of diagnostics and therapeutics, and relevant biological systems range from sub cellular structures to tissues. To utilize the unique core technologies effectively, the Shared Resource has been divided into two fundamental components, Service and Development. The service component has been extended by partnerships between the Developmental Biology Center, the Stem Cell Research Center, the Laboratory for Fluoresence Dynamics (LFD) and the newly organized Center for Complex Biosystems. The development component especially for diagnostics and basic subcellular applications has been dramatically enhanced by the appointment of a new facility manager (Dr. Michelle Digman) in partnership with the DEC and LFD and by the recent acquisition of new equipment through a partnership with the CCBS. The development of clinical diagnostics and therapeutics is strongly enhanced through the continuing partnership with the Beckman Laser Institute. A recent partnership with the Center for Immunology has expanded the instrumentation and expertise available for cytometry needs. The benefits to Cancer Center members are highly leveraged through these partnerships. Technical instruction, service and support are provided by three Shared Resource facilities and personnel namely, the OBC, the BLI and the Cytometry facility. The Shared Resource Director and co-Coordinators consult on initial experimental design and matching investigators with the proper facility and collaborator. Since a primary driving force behind optical biology is the development of new technology, the second component of the Shared Resource encourages development and utilization of novel optical methods in the basic science and clinical science programs. This is fostered by collaborative efforts between M. Digman and the LFD or T. Krasieva and the BLI.