REGULATION OF ALGINATE PRODUCTION IN THE BACTERIUM PSEUDOMONAS AERUGINOSA

铜绿假单胞菌中藻酸盐生产的调控

• 批准号: 7960262
• 负责人: DONALD W ROWEN
• 金额: $ 3.76万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960262
• 关键词: Alginates; Bacteria; Computer Retrieval of Information on Scientific Projects Database; Funding; Genome; Grant; Institution; Manuscripts; Nebraska; Peptide Hydrolases; Play; Production; Pseudomonas aeruginosa; Publications; Regulation; Research; Research Personnel; Resources; Role; Source; United States National Institutes of Health; Virulent; Work; functional genomics; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have identified Prc as a regulator of alginate production and are working to characterize its role. We believe that Prc is a protease that acts to degrade a key regulator of alginate production called MucA. We have just submitted a manuscript for publication that describes the identification of Prc and a partial characterization of its role in regulation alginate production. We are continuing our studies of Prc to fully characterize the mechanism by which it regulates alginate production. We have also begun studies to identify and characterize additional proteases that we believe act to regulate to regulate alginate production by degrading MucA. We have identified three candidates for these additional proteases in the bacterium's genome. We are beginning experiments to determine if one of our candidates actually does play a role in regulating alginate production. These experiments will enable us to understand how the production of alginate in induced in virulent strains by the degradation of MucA.

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