Toward an Animal Model of Freely Moving Human

建立自由移动的人类动物模型

• 批准号: 7841512
• 负责人: Krishna V Shenoy
• 金额: $ 83.15万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7841512
• 关键词: Address; Animal Model; Behavioral; Computers; Electrical Engineering; Eye; Head; Human; Investigation; Living Wills; Monitor; Monkeys; Motor Activity; Motor Cortex; Movement; Neurosciences; Performance; Posture; Prosthesis; Quality of life; Research; System; Technology; Training; Upper arm; Wireless Technology; abstracting; design; improved; motor control; neural prosthesis; neurophysiology; neuroregulation; patient population; relating to nervous system; research study; sound

DESCRIPTION Abstract I have trained as an electrical engineer and as a systems neurobiologist. Over the past ten years I have investigated how motor cortices guide arm movements and how this neural activity can be used to control prosthetic arms and computer cursors. I now recognize that a major new research direction is imperative if we are to truly understand the neural control of movement in the "real-world" and design neural prostheses for large numbers of people. The fundamental assumption which I call into question, and aim to address, is that cortical-motor activity is the same across behavioral contexts, contexts as different as sitting quietly in a dark room without moving ones eyes or head (conventional experimental setting) and actively moving around in a large space with lights, sounds and body posture constantly varying (the proposed "real world" setting). We must begin conducting electrophysiological experiments in monkeys able to freely move around in large spaces, which will serve as an animal model for freely moving humans. This is a dramatically new and different direction, which is only now plausible due to tremendous advances in microelectronics technology and the major new technological and experimental paradigms proposed here. I proposed to build a new suite of recording, wireless telemetery and behavioral monitoring technology to enable this new brand of basic and applied neuroscience investigation. We will also conduct a definitive set of neurophysiological and neural prosthetic experiments, to highlight the power and broad applicability of this new paradigm in addition to documenting initial, and likely highly surprising, discoveries. If successful, I anticipate this new experimental paradigm and results to greatly change basic neuroscience investigations of motor control, applied neuroscience/neuroengineering aimed at designing robust and high-performance neural prostheses, and large patient populations whose quality of life will be dramatically improved

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