INFECTIOUS DISEASES AND IMMUNOLOGY PROJECT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 传染病和免疫学项目(IDIP)的目标是协调和促进对新出现的传染病病原体及其给埃尔帕索-华雷斯地区人口带来的问题的研究。艾滋病毒的高感染率、耐药结核病的发病率以及对寄生虫感染的日益关注都是例子，但并不是正在调查的所有疾病及其病因。作为一条共同的线索，BBRC的研究人员正在研究导致疾病的病毒和原生动物，并研究免疫的基本机制，试图改善疾病应对措施。例如，正在研究的是微生物的目标分子及其刺激的免疫反应，这些分子可能会指导药物开发，导致更好地了解发病机制，或者转化为新的诊断和疫苗。IDIP历来通过BBRC核心实验室为其主要研究人员和其他调查人员提供强有力的、协调良好的支持，并将继续这样做。在新申请的RCMI资助周期内，为提高研究效率和能力，将实现的新的具体目标是：(1)利用RCMI支持的设施和通过促进内部和外部合作，提高我们在边境相关传染病方面的研究能力；(2)通过拟议的BBRC试点资助计划选择研究人员来促进教师发展；以及(3)通过招聘两名新的教员来加强该项目，他们将补充和扩展现有的研究工作。 通过与埃尔帕索德克萨斯大学公共卫生学院区域校区的调查人员、埃尔帕索德克萨斯科技卫生科学中心以及UTEP其他研究小组的合作，IDIP的活动也在扩大。与国际和平研究所联合开展的相关调查都需要BBRC核心实验室进行。正在申请资金，为国际和平研究所领导层提供行政用品和支助，以继续协调这些研究活动，并支付调查人员出席国家会议的旅费，在这些会议上，他们将介绍他们的发现。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of the Infectious Diseases and Immunology Project (IDIP) is to coordinate and facilitate the research on emerging infectious agents and the problems they present to the population of the El Paso-Ciudad Juarez region. The high rate of infections with HIV, the incidence of drug-resistant tuberculosis and a growing concern about parasitic infections are examples but not a full spectrum of diseases and their etiologies being investigated. As a common thread, BBRC researchers are studing disease causing viruses and protozoa and investigating basic mechanisms of immunity in attempts to improve disease counter measures. For example, being studied are target molecules of microbes and immune reactions stimulated by them that might guide drug development, lead to a better understanding of pathogenesis, or translate into new diagnostics and vaccines. The IDIP has historically provided strong, well coordinated support, through BBRC Core Laboratories, for its primary researchers and other investigators, and will continue to do so. New specific Aims to be achieved during this newly requested RCMI funding cycle to enhance research productivity and capacity are (1) To enhance our research capabilities on border-related infectious diseases using RCMI Supported Facilities and by promoting internal and external collaborations; (2) To promote faculty development by selecting the investigators for funding via the proposed BBRC Pilot Grant Initiatives, and (3) To strengthen the project by recruiting two new faculty members who will complement and extend current research efforts. Expansion of IDIP activities is also occurring through collaborations with investigators at the University of Texas School of Public Health Regional Campus in El Paso, the Texas Tech Health Science Center in El Paso, and with other UTEP research groups. Related investigations carried out in association with the IDIP all require BBRC Core Laboratories for execution. Funds are being requested to provide administrative supplies and support for IDIP leadership to continue the coordination of these research activities and to offset travel costs of investigators to attend national meetings where they will present their discoveries.