Optimising combinations of calcium channel inhibitors for treatment of secondary degeneration after neurotrauma
Optimising combinations of calcium channel inhibitors for treatment of secondary degeneration after neurotrauma
批准号:
nhmrc : 1061791
负责人:
A/Pr Livia Hool
金额:
$45.33万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2016-12-31
中文摘要
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英文摘要
Traumatic injury to the central nervous system is made worse by damage that spreads away from the initial point of impact. Excess calcium entering cells is a key contributor to spreading damage but treatment with single calcium channel inhibitors has been disappointing. We will use combinations of calcium channel inhibitors to block multiple calcium channels and ensure the optimised combination is effective in clinically relevant models of neurotrauma.
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