Optimising combinations of calcium channel inhibitors for treatment of secondary degeneration after neurotrauma

优化钙通道抑制剂组合治疗神经外伤后继发性变性

• 批准号: nhmrc : 1061791
• 负责人: A/Pr Livia Hool
• 金额: $ 45.33万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/optimising-combinations-calcium-degeneration-neurotrauma/454931
• 关键词: Optimising; combinations; calcium; channel; inhibitors

Traumatic injury to the central nervous system is made worse by damage that spreads away from the initial point of impact. Excess calcium entering cells is a key contributor to spreading damage but treatment with single calcium channel inhibitors has been disappointing. We will use combinations of calcium channel inhibitors to block multiple calcium channels and ensure the optimised combination is effective in clinically relevant models of neurotrauma.

对中枢神经系统的创伤性损伤由于从最初的撞击点扩散而变得更糟。过量的钙进入细胞是扩散损伤的关键因素，但单钙通道抑制剂的治疗效果令人失望。我们将使用钙通道抑制剂的组合来阻断多种钙通道，并确保优化的组合在临床相关的神经创伤模型中有效。