Characterising the effects of oxidative stress on the human L-type Ca2+ channel isoforms and role in human pathology
Characterising the effects of oxidative stress on the human L-type Ca2+ channel isoforms and role in human pathology
批准号:
nhmrc : 1002207
负责人:
A/Pr Livia Hool
金额:
$16.72万
依托单位国家:
澳大利亚
项目类别:
Research Fellowships
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2016-12-31
中文摘要
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英文摘要
Oxidative stress, poor energy production and increases in intracellular calcium are features of the failing heart. I have determined that the function of the L-type calcium channel, the primary protein responsible for calcium influx and contraction can be regulated by free radicals produced by the mitochondria (powerhouse of the cell). This proposal will determine the site of modification on the human L-type calcium channel and how communication between the channel and the mitochondria is altered in animal models of human disease.
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