The L-type calcium channel in cardiovascular health and disease

L 型钙通道在心血管健康和疾病中的作用

• 批准号: nhmrc : GNT1117366
• 负责人: A/Pr Livia Hool
• 金额: $ 63.14万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/l-type-calcium-health-disease/1347029
• 关键词: type; calcium; channel; cardiovascular; health

Calcium influx into cardiac muscle cells occurs via the L-type calcium channel. The channel is essential to life but when function is altered it can contribute to the development of sudden death and heart failure. I have made significant discoveries in understanding the role of the channel in disease and I have exploited this knowledge to design therapy including a novel class of calcium channel antagonists to prevent the development of heart failure.

钙离子通过L型钙通道流入心肌细胞。该通道对生命至关重要，但当功能改变时，它可能会导致猝死和心力衰竭的发展。我在理解通道在疾病中的作用方面有了重大发现，我利用这些知识设计了治疗方法，包括一类新型钙通道拮抗剂，以防止心力衰竭的发展。