Experimental Tacaribe Virus Infection of Jamaican Fruit Bats
牙买加果蝠的实验性塔卡里布病毒感染
基本信息
- 批准号:7935594
- 负责人:
- 金额:$ 40.27万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-07-19 至 2013-06-30
- 项目状态:已结题
- 来源:
- 关键词:American Hemorrhagic FeverAnimal ModelAnimalsArenavirusCardiacCaribbean regionCell Culture TechniquesCell LineChiropteraCoronavirusDiseaseDoseEvaluationEventExhibitsFilovirusFruitGene ExpressionGenesHemorrhageHenipavirusHumanImmuneImmune responseImmunologyInfectionInfectious AgentJunin virusLiverNeurologicNeurologic ManifestationsParamyxovirusPathogenesisPathologyPulmonary PathologySARS coronavirusSiteSouth AmericanSouth American hemorrhagic fever virusesSymptomsT-LymphocyteTacaribe virusTremorTrinidadViral Hemorrhagic FeversViral Load resultVirusVirus DiseasesVirus ReplicationWorkhuman diseasepathogenpublic health relevanceresponsevirus pathogenesis
项目摘要
DESCRIPTION (provided by applicant): Bats have recently been shown to harbor several infectious agents of human disease, including SARS-like coronaviruses, henipaviruses and filoviruses. Tacaribe virus, an arenavirus that can cause hemorrhagic fever in humans, has only been isolated from fruit bats (Artibeus spp.) captured in Trinidad. It is unknown if these bats are a natural reservoir of Tacaribe virus, but we have demonstrated that low-dose infection can cause persistent infection for at least 45 days without conspicuous symptoms of disease. In addition, high-dose infection causes a fatal disease that has some similarity to the South American hemorrhagic fevers that are caused by other arenaviruses, including neurological manifestations and hemorrhaging. This project will detail the pathological and immunological responses of Jamaican fruit bats experimentally infected with Tacaribe virus in an effort to determine if the species can be a reservoir and a suitable animal model for arenavirus pathogenesis.
PUBLIC HEALTH RELEVANCE: Arenaviruses can cause fatal hemorrhagic fevers in humans. Little is known about the pathogenesis of these viruses and the work proposed here will examine the pathology and immunology of one such virus, Tacaribe virus, in its suspect reservoir animal, the Jamaican fruit bat.
描述(由申请人提供):最近已证明蝙蝠携带多种人类疾病传染源,包括 SARS 样冠状病毒、亨尼帕病毒和丝状病毒。塔卡里布病毒是一种可引起人类出血热的沙粒病毒,仅从特立尼达捕获的果蝠(Artibeus spp.)中分离出来。目前尚不清楚这些蝙蝠是否是塔卡里贝病毒的天然宿主,但我们已经证明,低剂量感染可导致持续感染至少 45 天,而不会出现明显的疾病症状。此外,高剂量感染会导致致命疾病,与其他沙粒病毒引起的南美出血热有一些相似之处,包括神经系统表现和出血。该项目将详细介绍实验性感染塔卡里布病毒的牙买加果蝠的病理和免疫反应,以确定该物种是否可以成为沙粒病毒发病机制的储存库和合适的动物模型。
公共卫生相关性:沙粒病毒可引起人类致命的出血热。人们对这些病毒的发病机制知之甚少,这里提出的工作将检查其中一种病毒(塔卡里贝病毒)在其可疑宿主动物牙买加果蝠中的病理学和免疫学。
项目成果
期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Transcriptome sequencing and annotation for the Jamaican fruit bat (Artibeus jamaicensis).
牙买加水果蝙蝠(Artibeus Jamaicensis)的转录组测序和注释。
- DOI:10.1371/journal.pone.0048472
- 发表时间:2012
- 期刊:
- 影响因子:3.7
- 作者:Shaw TI;Srivastava A;Chou WC;Liu L;Hawkinson A;Glenn TC;Adams R;Schountz T
- 通讯作者:Schountz T
Transcriptomic Signatures of Tacaribe Virus-Infected Jamaican Fruit Bats.
- DOI:10.1128/msphere.00245-17
- 发表时间:2017-09-01
- 期刊:
- 影响因子:4.8
- 作者:Gerrard, Diana L;Hawkinson, Ann;Frietze, Seth
- 通讯作者:Frietze, Seth
Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis).
- DOI:10.1038/srep21878
- 发表时间:2016-02-22
- 期刊:
- 影响因子:4.6
- 作者:Munster VJ;Adney DR;van Doremalen N;Brown VR;Miazgowicz KL;Milne-Price S;Bushmaker T;Rosenke R;Scott D;Hawkinson A;de Wit E;Schountz T;Bowen RA
- 通讯作者:Bowen RA
Zaire ebolavirus surveillance near the Bikoro region of the Democratic Republic of the Congo during the 2018 outbreak reveals presence of seropositive bats.
- DOI:10.1371/journal.pntd.0010504
- 发表时间:2022-06
- 期刊:
- 影响因子:3.8
- 作者:
- 通讯作者:
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William A Schountz其他文献
William A Schountz的其他文献
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{{ truncateString('William A Schountz', 18)}}的其他基金
3rd International Infectious Diseases of Bats Symposium
第三届国际蝙蝠传染病研讨会
- 批准号:
9913043 - 财政年份:2021
- 资助金额:
$ 40.27万 - 项目类别:
2nd International Infectious Diseases of Bats Symposium
第二届国际蝙蝠传染病研讨会
- 批准号:
9331362 - 财政年份:2017
- 资助金额:
$ 40.27万 - 项目类别:
Deer Mice as Immunological Tools for Infectious Disease
鹿鼠作为传染病的免疫工具
- 批准号:
7127390 - 财政年份:2006
- 资助金额:
$ 40.27万 - 项目类别:
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