2010 Single-Molecule Approaches to Biology Gordon Research Conference

2010 年单分子生物学方法戈登研究会议

• 批准号: 7904388
• 负责人: William E Moerner
• 金额: $ 0.7万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-15 至 2011-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7904388
• 关键词: Behavior; Biochemical; Biological; Biology; Biomedical Engineering; Biophysical Process; Biophysics; Cells; Cellular biology; DNA Sequence; Data; Development; Goals; Health; Human; Image; Individual; International; Italy; Knowledge; Life; Measurement; Methods; Molecular; Molecular Machines; Participant; RNA-Protein Interaction; Request for Proposals; Research; Resolution; Series; Spectrum Analysis; Techniques; Work; improved; innovation; meetings; method development; novel; novel strategies; pathogen; posters; programs; public health relevance; single molecule; symposium; synthetic biology

DESCRIPTION (provided by applicant): This proposal requests partial support for an international conference titled "Single-Molecule Approaches to Biology" as part of the Gordon Research Conference series to be held at Il Ciocco, Lucca (Barga), Italy, June 27 - July 2, 2010. The ability of single-molecule approaches to avoid ensemble averaging and to capture transient intermediates and heterogeneous behavior renders them particularly powerful in elucidating mechanisms of the molecular machines central to biology. By observing individuals, it is possible to more deeply understand what they do, how they work individually, how they work together, and finally, how they work inside live cells. This conference seeks to bring together top experts in molecular and cell biology with innovators in the measurement and manipulation of single molecules. The goals are to better promote the use of the single-molecule approach, to generate new biological knowledge, and to better inform the development and implementation of single- molecule techniques for compelling biological problems. The specific aims of this meeting are to convene 40 senior and emerging speakers who represent new thrusts of single-molecule research with a total of 170 participants for a five day conference in a relatively isolated setting. The program will cover cutting-edge developments in single-molecule sequencing, DNA/RNA/protein interactions, folding machines, cellular biophysics, synthetic biology and bioengineering, force spectroscopy, new method developments, super resolution imaging in cells, and novel probes for single-molecule imaging. In addition, four poster sessions will give participants various opportunities to actively participate in the scientific discourse. The significance of this application is that the Gordon Research Conference on Single-Molecule Approaches to Biology is a powerful vehicle to promote and enhance the exchange between emerging/innovative methods and important biological problems. The health-relatedness of this application derives from the fact that single-molecule approaches provide previously unobtainable data on fundamental biochemical and biophysical processes that are essential for all forms of life, including human pathogens, thus extending our knowledge and generating new approaches to improving human health. PUBLIC HEALTH RELEVANCE: The health-relatedness of this application derives from the fact that single- molecule approaches to biology provide previously unobtainable data on fundamental biochemical and biophysical processes that are essential for all forms of life, including human pathogens, thus extending our knowledge and generating new approaches to improving human health.

描述(由申请人提供)：本提案请求部分支持将于2010年6月27日至7月2日在意大利卢卡的Il Ciocco举行的名为“单分子生物学方法”的国际会议，作为戈登研究会议系列的一部分。单分子方法避免系综平均和捕捉瞬时中间体和异质行为的能力使它们在阐明生物学中心的分子机器的机制方面特别强大。通过观察个体，可以更深入地了解他们做什么，他们如何单独工作，他们如何共同工作，最后，他们如何在活细胞内工作。本次会议旨在让分子和细胞生物学领域的顶尖专家与单分子测量和操作领域的创新者汇聚一堂。目标是更好地促进单分子方法的使用，产生新的生物学知识，并更好地为单分子技术的开发和实施提供信息，以解决紧迫的生物学问题。这次会议的具体目标是召集40名代表单分子研究新推动力的资深和新兴演讲者，总共170名与会者，在一个相对孤立的环境中举行为期五天的会议。该计划将涵盖单分子测序、DNA/RNA/蛋白质相互作用、折叠机、细胞生物物理学、合成生物学和生物工程、力光谱、新方法开发、细胞超分辨率成像以及用于单分子成像的新型探针等领域的前沿开发。此外，四个海报会议将为与会者提供各种机会，积极参与科学话语。这一应用的意义在于，戈登生物学单分子方法研究会议是促进和加强新兴/创新方法和重要生物学问题之间交流的强大工具。这一应用之所以与健康有关，是因为单分子方法提供了以前无法获得的基本生化和生物物理过程的数据，这些过程对包括人类病原体在内的所有形式的生命都是必不可少的，从而扩大了我们的知识，并产生了改善人类健康的新方法。 公共卫生相关性：这一应用之所以与健康相关，是因为生物学的单分子方法提供了以前无法获得的基本生化和生物物理过程的数据，这些过程对包括人类病原体在内的所有形式的生命都是必不可少的，从而扩大了我们的知识，并产生了改善人类健康的新方法。