Optimising targeted polyamine depletion for treatment of childhood neuroblastoma and brain tumours

优化靶向多胺消耗以治疗儿童神经母细胞瘤和脑肿瘤

• 批准号: nhmrc : 1125036
• 负责人: A/Pr David Ziegler
• 金额: $ 63.36万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/optimising-targeted-polyamine-brain-tumours/947494
• 关键词: Optimising; targeted; polyamine; depletion; treatment

Paediatric neuroblastoma and brain tumours, which often have dismal outcomes despite intensive therapy, have high levels of polyamines, which are essential for cell growth. We have shown that depleting polyamines, combined with chemotherapy, represents a highly promising therapy for neuroblastoma. We will make this exciting new treatment approach even more effective by comparing three ways of enhancing polyamine depletion, as a precursor to future neuroblastoma and brain tumour clinical trials.

儿科神经母细胞瘤和脑肿瘤，尽管进行了强化治疗，但结果往往令人沮丧，它们含有高水平的多胺，这对细胞生长至关重要。我们已经表明，耗尽多胺，结合化疗，是一个非常有前途的治疗神经母细胞瘤。我们将通过比较三种增强多胺消耗的方法，使这种令人兴奋的新治疗方法更加有效，作为未来神经母细胞瘤和脑肿瘤临床试验的先驱。