Targeted inhibition of polyamine synthesis for treatment of childhood neuroblastoma

儿童癌症，神经母细胞瘤，尽管使用了强化治疗，但结果往往令人沮丧。多胺是细胞生存所必需的分子，在侵袭性神经母细胞瘤中增加。使用临床前模型，我们已经表明，抑制多胺的产生可以显著延缓神经母细胞瘤的生长。该项目旨在通过多胺合成的多个步骤与化疗相结合来提高这种治疗的整体疗效。

The childhood cancer, neuroblastoma, frequently has a dismal outcome despite the use of intensive therapy. Polyamines are molecules that are essential for cell survival and these are increased in aggressive neuroblastoma. Using pre-clinical models, we have shown that inhibiting polyamine production can significantly delay neuroblastoma growth. This project aims to improve the overall efficacy of this treatment by targeting multiple steps in polyamine synthesis in combination with chemotherapy.