Targeted inhibition of polyamine synthesis for treatment of childhood neuroblastoma

儿童癌症，神经母细胞瘤，经常有一个令人沮丧的结果，尽管使用强化治疗。多胺是细胞生存所必需的分子，并且在侵袭性神经母细胞瘤中增加。使用临床前模型，我们已经表明，抑制多胺的生产可以显着延迟神经母细胞瘤的生长。该项目旨在通过靶向多胺合成中的多个步骤与化疗相结合来提高这种治疗的总体疗效。

The childhood cancer, neuroblastoma, frequently has a dismal outcome despite the use of intensive therapy. Polyamines are molecules that are essential for cell survival and these are increased in aggressive neuroblastoma. Using pre-clinical models, we have shown that inhibiting polyamine production can significantly delay neuroblastoma growth. This project aims to improve the overall efficacy of this treatment by targeting multiple steps in polyamine synthesis in combination with chemotherapy.