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Determining the impacts of epigenetic modifying drugs on germline programming and offspring health

Determining the impacts of epigenetic modifying drugs on germline programming and offspring health
确定表观遗传修饰药物对种系编程和后代健康的影响
批准号:
nhmrc : 1144887
负责人:
A/Pr David Ziegler
金额:
$58.41万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2020-12-31

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中文摘要
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英文摘要
New drugs have been developed that inhibit specific enzymes that regulate epigenetic pathways in cells. These pathways significantly affect growth and development in offspring and may represent a risk to future children of patients taking the drug. This project will determine these risks and provide data for developing clinical guidelines for safe use of the drugs.
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Determining the impacts of epigenetic modifying drugs on germline programming and offspring health
  • 批准号:
    nhmrc : GNT1144887
  • 项目类别:
    Project Grants
  • 资助金额:
    $86.39万
  • 财政年份:
    2018
  • 负责人:
    A/Pr David Ziegler
  • 依托单位:
Optimising targeted polyamine depletion for treatment of childhood neuroblastoma and brain tumours
  • 批准号:
    nhmrc : GNT1125036
  • 项目类别:
    Project Grants
  • 资助金额:
    $92.82万
  • 财政年份:
    2017
  • 负责人:
    A/Pr David Ziegler
  • 依托单位:
Optimising targeted polyamine depletion for treatment of childhood neuroblastoma and brain tumours
  • 批准号:
    nhmrc : 1125036
  • 项目类别:
    Project Grants
  • 资助金额:
    $63.36万
  • 财政年份:
    2017
  • 负责人:
    A/Pr David Ziegler
  • 依托单位:
Targeted Inhibition of the FACT (Facilitates Chromatin Transcription) Complex as a Novel Therapeutic Approach in Aggressive Childhood Cancers
  • 批准号:
    nhmrc : GNT1085411
  • 项目类别:
    Project Grants
  • 资助金额:
    $99.07万
  • 财政年份:
    2015
  • 负责人:
    A/Pr David Ziegler
  • 依托单位:
国内基金
海外基金
IMPACTS站点土壤铝活化机制研究