Determining the impacts of epigenetic modifying drugs on germline programming and offspring health

确定表观遗传修饰药物对种系编程和后代健康的影响

• 批准号: nhmrc : 1144887
• 负责人: A/Pr David Ziegler
• 金额: $ 58.41万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/determining-impacts-epigenetic-offspring-health/1320298
• 关键词: Determining; impacts; epigenetic; modifying; drugs

New drugs have been developed that inhibit specific enzymes that regulate epigenetic pathways in cells. These pathways significantly affect growth and development in offspring and may represent a risk to future children of patients taking the drug. This project will determine these risks and provide data for developing clinical guidelines for safe use of the drugs.

新药已经开发出来，可以抑制调节细胞表观遗传途径的特定酶。这些途径显著影响后代的生长和发育，并可能对服用该药物的患者未来的子女构成风险。该项目将确定这些风险，并为制定药物安全使用的临床指南提供数据。