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Targeted Inhibition of the FACT (Facilitates Chromatin Transcription) Complex as a Novel Therapeutic Approach in Aggressive Childhood Cancers

Targeted Inhibition of the FACT (Facilitates Chromatin Transcription) Complex as a Novel Therapeutic Approach in Aggressive Childhood Cancers
靶向抑制 FACT（促进染色质转录）复合物作为侵袭性儿童癌症的新型治疗方法
批准号：
nhmrc : GNT1085411
负责人：
A/Pr David Ziegler
金额：
$99.07万
依托单位：
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2015
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2015-01-01 至 --
来源：
https://researchdata.edu.au/targeted-inhibition-fact-childhood-cancers/1345625
关键词：
TargetedInhibitionFACTFacilitatesChromatin

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中文摘要
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英文摘要
Our research focusses on the most aggressive of all childhood cancers, and our aim is to develop novel therapies for these malignancies. We have discovered a new drug target called 'FACT' in aggressive brain and solid tumours of childhood. Targeting FACT with a new class of drugs termed 'curaxins' has a powerful anti-tumour effect. We aim to investigate the potential of these drugs as a new, effective therapy for incurable childhood cancers.
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Optimising targeted polyamine depletion for treatment of childhood neuroblastoma and brain tumours
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Optimising targeted polyamine depletion for treatment of childhood neuroblastoma and brain tumours
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    The University of New South Wales
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