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Targeted Inhibition of the FACT (Facilitates Chromatin Transcription) Complex as a Novel Therapeutic Approach in Aggressive Childhood Cancers

Targeted Inhibition of the FACT (Facilitates Chromatin Transcription) Complex as a Novel Therapeutic Approach in Aggressive Childhood Cancers
靶向抑制 FACT（促进染色质转录）复合物作为侵袭性儿童癌症的新型治疗方法
批准号：
nhmrc : 1085411
负责人：
A/Pr David Ziegler
金额：
$68.65万
依托单位：
The University of New South Wales
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2015
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2015-01-01 至 2018-12-31
来源：
https://researchdata.edu.au/targeted-inhibition-fact-childhood-cancers/519085
关键词：
TargetedInhibitionFACTFacilitatesChromatin

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中文摘要
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英文摘要
Our research focusses on the most aggressive of all childhood cancers, and our aim is to develop novel therapies for these malignancies. We have discovered a new drug target called "FACT" in aggressive brain and solid tumours of childhood. Targeting FACT with a new class of drugs termed "curaxins" has a powerful anti-tumour effect. We aim to investigate the potential of these drugs as a new, effective therapy for incurable childhood cancers.
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    nhmrc : GNT1144887
  • 项目类别：
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Optimising targeted polyamine depletion for treatment of childhood neuroblastoma and brain tumours
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    nhmrc : GNT1125036
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  • 财政年份：
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  • 依托单位：
Optimising targeted polyamine depletion for treatment of childhood neuroblastoma and brain tumours
  • 批准号：
    nhmrc : 1125036
  • 项目类别：
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    $63.36万
  • 财政年份：
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    A/Pr David Ziegler
  • 依托单位：
    The University of New South Wales
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