Fourth Annual Symposium on Nephrogenic Systemic Fibrosis and Gadolinium Based Con

第四届肾源性系统纤维化和钆基Con年度研讨会

• 批准号: 7915991
• 负责人: ali abu-alfa
• 金额: $ 0.5万
• 依托单位: NEW YORK ACADEMY OF SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7915991
• 关键词: Academy; Cells; Clinical; Collaborations; Communication; Contrast Media; Dermatology; Diagnostic; Disease; FASN gene; Fibrosis; Functional disorder; Gadolinium; Grant; Individual; Internal Medicine; Kidney; Magnetic Resonance Imaging; Medicine; Nephrology; New York; Participant; Pathology; Patients; Populations at Risk; Principal Investigator; Published Comment; Radiology Specialty; Rare Diseases; Research; Rheumatology; Risk; Science; Scientist; Therapeutic; Universities; Work; base; career; medical schools; meetings; next generation; professor; skin disorder; symposium

DESCRIPTION (provided by applicant): Yale School of Medicine and The New York Academy of Sciences are planning an important 1.5 day conference entitled, "Fourth Annual Symposium on Nephrogenic Systemic Fibrosis and Gadolinium Based Contrast Agents." This meeting will be held on May 14-15, 2010 at the New York Academy of Sciences, New York. The principal investigator for this conference is Dr. Ali K. Abu-Alfa, MD, FASN; Associate Professor of Medicine; Department of Internal Medicine; Section of Nephrology; Yale School of Medicine; Co PI on this grant is Dr. Shawn E. Cowper, Associate Professor of Dermatology and Pathology; Department of Dermatology; Yale University School of Medicine. This meeting will discuss Nephrogenic Systemic Fibrosis (NSF), a rare skin disorder known to be highly associated with, and very likely triggered by, gadolinium based magnetic resonance imaging contrast agents (GBCA). This man-made disease predominates in individuals with preexisting renal dysfunction. Overall, the breadth of discussions will extend from the cells and atoms responsible for NSF to the entire population at risk. Discussions will examine the therapeutic and mechanistic aspects of NSF as to better understand this rare disease from both a clinical and scientific viewpoint. In addition, the management of patients at-risk in need of MR diagnostic magnetic resonance imaging (MRI) with GBCA will be discussed. Of greater importance, perhaps, is the impact this work will have on the fundamental understanding of fibrosis in general, opening up new avenues of inquiry into disease mechanisms previously thought to be unchallengeable by medicine. This meeting will bring together clinicians and scientists, chiefly in nephrology, radiology, rheumatology, dermatology and pathology. Participants will include both established and young career scientists and clinicians, providing a platform for the next generation to enter this field. Furthermore, this conference is anticipated to increase communication and subsequent collaboration between complimentary research groups. Project Narrative This meeting will discuss Nephrogenic Systemic Fibrosis (NSF), a rare skin disorder known to be highly associated with, and very likely triggered by, gadolinium based magnetic resonance imaging contrast agents. This man-made disease predominates in individuals with pre-existing renal dysfunction. Discussions will examine the therapeutic and mechanistic aspects of NSF to examine this rare disease from both a clinical and scientific viewpoint. Of greater importance, perhaps, is the impact this work will have on the fundamental understanding of fibrosis in general, opening up new avenues of understanding into disease mechanisms previously thought to be unchallengeable by medicine.

描述(申请人提供)：耶鲁大学医学院和纽约科学院正在筹划一场为期1.5天的重要会议，题为“第四届肾源性系统性纤维化和基于Gd的造影剂的年度研讨会”。本次会议将于2010年5月14日至15日在纽约纽约科学院举行。本次会议的主要研究员是阿里·K·阿布-阿尔法博士，医学博士，FASN，内科副教授，耶鲁大学医学院肾脏病学部，耶鲁大学医学院皮肤病学系副教授肖恩·E·考珀博士。本次会议将讨论肾源性系统性纤维化(NSF)，这是一种罕见的皮肤病，已知与基于Gd的磁共振成像造影剂(GBCA)高度相关，并且很可能由其引发。这种人为疾病主要发生在既往存在肾功能障碍的患者中。总体而言，讨论的广度将从负责NSF的细胞和原子延伸到整个面临风险的人群。讨论将检查NSF的治疗和机制方面，以更好地从临床和科学角度理解这种罕见的疾病。此外，还将讨论对需要使用GBCA的MR诊断磁共振成像(MRI)的高危患者的处理。也许，更重要的是，这项工作将对对纤维化的基本理解产生影响，为探索以前被认为是医学上不可挑战的疾病机制开辟了新的途径。这次会议将汇集临床医生和科学家，主要是肾脏病、放射学、风湿病、皮肤病和病理学。参与者将包括成熟的和年轻的职业科学家和临床医生，为下一代进入这一领域提供平台。此外，预计这次会议将加强互惠研究小组之间的交流和随后的合作。 项目叙事 本次会议将讨论肾源性全身性纤维化(NSF)，这是一种罕见的皮肤病，已知与基于Gd的磁共振成像造影剂高度相关，并且很可能由其引发。这种人为疾病主要发生在既往存在肾功能障碍的个体中。讨论将检查NSF的治疗和机制方面，以从临床和科学的角度检查这种罕见的疾病。也许更重要的是，这项工作将对对纤维化的基本理解产生影响，为理解以前被认为是医学上不可挑战的疾病机制开辟了新的途径。