2010 Oxygen Radicals: Mechanisms that Underpin Redox Biology - a Gordon Research

描述(申请人提供)：戈登研究会议“氧自由基：氧化还原生物学的基础机制”旨在为化学家、生物学家、生物化学家、细胞生物学家、临床医生和其他生物医学科学家提供关于化学和生物系统中的活性氧物种及其与包括一氧化氮在内的其他自由基的相互作用的最新知识。本次研究会议每两年举行一次；下一次会议将于2010年2月7日至12日在加利福尼亚州文图拉的Four Points喜来登/假日快捷酒店举行。自1981年以来，已举行了15次会议；根据大量申请者和会后评价，这些会议已证明非常富有成效。请拨资金部分用于支付来自美国和国外的演讲者以及富有成效的研究生/博士后候选人的旅费、生活费和注册费。本方案中列出的发言者是根据上届会议的前任主席、联合主席和与会者的建议选出的。演讲者被邀请介绍他们关于氧化还原生物学基础的最新研究。会议主题包括：氧化应激、氧化还原生物学和疾病；炎症和氧化应激；心血管疾病中的氧化事件；硫醇氧化和硫醇酶的生物化学；氮氧化物和硫化氢；蛋白质氧化、氧化还原变化和衰老；线粒体，氧化还原平衡的中心；氧化应激的生物标志物和检测氧化应激的方法；以及过去和未来的超氧化物歧化酶。受邀的演讲者代表了当前和未来的领导者，他们致力于研究影响炎症、肺部和心血管疾病、癌症、毒理学和其他人类健康问题(包括衰老)的自由基和氧化还原生物学研究的基本方面。此外，乔·麦考德教授还将发表题为《超氧化物歧化酶和自由基生物学：开始、现在和尝试猜测未来》的主旨演讲。预计将有60-80张海报分别在两天的海报会议上发布。根据戈登会议的规定，总出席人数将限制在160人以内。戈登研究会议为参与者和研究领域的多样性提供了一个极好和必要的论坛。本次戈登研究会议的主要优势是为不同学科的科学家提供了以延长和不间断的方式进行互动的机会。这种类型的互动通常会导致新的合作研究倡议。戈登生物氧自由基研究会议在探索这一重要和临床相关领域的前沿研究方面发挥了至关重要的作用。 公共卫生相关性：该申请寻求对2010年戈登研究会议(GRC)的部分支持，该会议将于2010年2月7日至12日在加利福尼亚州文图拉举行，主题是氧自由基：氧化还原生物学的基础机制。这次科学会议将为交流这一领域的最新研究成果提供一个论坛。由于它强调健康和疾病中的基本化学和生化机制，它将有利于从化学家到临床医生的广泛研究人员。

DESCRIPTION (provided by applicant): The Gordon Research Conference on "Oxygen Radicals: Mechanisms that Underpin Redox Biology" is designed to provide chemists, biologists, biochemists, cell biologists, clinicians, and other biomedical scientists with state-of-the-art knowledge on reactive oxygen species and their interactions with other radicals, including nitric oxide, in chemical and biological systems. This research conference is held every two years; the next meeting will be held February 7-12, 2010 at the Four Points Sheraton / Holiday Inn Express, Ventura, CA. Fifteen conferences have been held since 1981; they have proven to be extremely productive based on the large number of applicants and the post-meeting evaluations. Funds are requested to partially support travel, subsistence, and registration costs for speakers from the United States and abroad as well as productive graduate students/post-doctoral candidates. The speakers listed in this program were selected based on the suggestions from the previous chairs, co-chairs and attendees at the past conference. Speakers have been invited to present their latest research on the fundamentals of redox biology. Session topics will include: oxidative stress, redox biology, & disease; inflammation & oxidative stress; oxidative events in cardiovascular disease; biochemistry of thiol oxidation & thiol enzymes; nitrogen oxides & hydrogen sulfide; protein oxidation, redox changes & aging; mitochondria, central to redox balance; biomarkers & methods for detecting oxidative stress; and super oxide dismutases, past present and future. The invited speakers represent current and future leaders that address fundamental aspects of free radical and redox biology research that impacts inflammation, pulmonary and cardiovascular diseases, cancer, toxicology, and other issues of human health, including aging. In addition, Professor Joe McCord will present a Keynote Lecture entitled: "Superoxide Dismutase and Free Radical Biology: The Beginnings, the Present, and Trying to Guess the Future" Two separate poster sessions of two days each are scheduled for an anticipated 60-80 posters. Total attendance will be limited to 160 by Gordon Conference rules. The Gordon Research Conference provides an excellent and needed forum for the diversity of both participants and research areas. The main strength of this Gordon Research Conference is the opportunities offered for scientists in different disciplines to interact in an extended and uninterrupted fashion. This type of interaction generally results in new collaborative research initiatives. The Gordon Research Conference on Oxygen Radicals in Biology plays a crucial role in exploring frontier research in this important and clinically-relevant field. PUBLIC HEALTH RELEVANCE: The application seeks partial support for the 2010 Gordon Research Conference (GRC) on Oxygen Radicals: Mechanisms that underpin redox biology to be held in Ventura, CA Feb 7 -12 2010. This scientific meeting will provide a forum for the exchange of the most recent research findings in this field. Because of it emphasis on basic chemical and biochemical mechanisms in health and disease, it will be of benefit to a broad range of researchers, ranging from chemists to clinicians.