2010 Biomolecular Interactions & Methods GRC & GRS

描述（由申请人提供）：本提案寻求部分支持联合戈登会议：(1)戈登生物分子相互作用和方法研究会议（2010年1月17日至22日）；和/或(2)与之配套的戈登研究研讨会，由博士后和博士后科学家组织（2010年1月16日至17日）。这两次会议都将在德克萨斯州加尔维斯顿的同一地点举行，我们预计参加GRS的许多年轻科学家也将参加随后的GRC。这些会议的广泛和长期目标是促进我们对生物分子复合物的定量理解，以便我们可以表征生物功能，疾病和治疗干预的分子基础。2010年会议的主题是蛋白质相互作用动力学：理论、方法和实践，将探讨表征蛋白质动力学的最新技术，蛋白质运动对结合相互作用的影响，以及生物系统中分子结合的动力学。杰米·威廉姆森博士（斯克里普斯）将发表主题演讲，介绍他的开创性研究，推动质谱技术解决当代核糖体组装问题。此外，会议还包括九场科学会议，既有受邀演讲者，也有提交摘要的介绍；生动和高度互动的海报会议补充了正式的演讲。在2010年的主要会议之前，将有一个由细胞生物学和生物热力学领域的博士后和博士预科生计划的周末会议。这次会议是戈登-凯南生物分子相互作用与方法研究生研究研讨会，将为这些未来的领域领导者提供一个论坛，在一个学院和互动的环境中展示他们的工作，这将为他们的整体GRC经验增加突出的价值。这次会议为科学家们提供了一个独特的机会，在一个以讨论为导向的会议上关注蛋白质相互作用动力学这一高度跨学科的主题。这一应用与健康的关系在于，生物分子相互作用是所有生物过程的基础，对这些过程的详细了解对于理解疾病的分子基础和开发新疗法至关重要。

DESCRIPTION (provided by applicant): This proposal seeks partial support for joint Gordon Conference meetings: (1) the Gordon Research Conference on Biomolecular Interactions and Methods (Jan 17-22, 2010); and/or (2) its accompanying Gordon Research Symposium, which is organized by and for pre- and postdoctoral scientists (Jan 16-17, 2010). Both meetings will take place in Galveston, TX at the same venue, and we anticipate that many of the young scientists attending the GRS will also participate in the subsequent GRC. The broad and long-term goal of these meetings is to advance our quantitative understanding of biomolecular complexes so that we may characterize the molecular basis for biological functions, disease, and therapeutic intervention. The theme of the 2010 meetings, Protein Interaction Dynamics: Theory, Methods, and Practice, will explore the state-of-the-art for characterizing protein dynamics, the effect of protein motions on binding interactions, and the dynamics of molecular associations in biological systems. Dr. Jamie Williamson (Scripps) will present a keynote address on his pioneering research that pushes mass spectrometry technology to address the contemporary problem of ribosome assembly. In addition, the meeting includes nine scientific sessions with both invited speakers as well as presentations from submitted abstracts; lively and highly interactive poster sessions complement the formal presentations. In 2010, the main conference will be preceded by a weekend meeting planned by and for post-doctoral and pre-doctoral trainees in the field of cell biology and biothermodynamics. This meeting, the Gordon-Kenan Graduate Research Seminar on Biomolecular Interactions & Methods, will provide a forum for these future leaders in the field to present their work in talks and posters, in a collegial and interactive environment that will add outstanding value to their overall GRC experience. This meeting provides a unique opportunity for scientists to focus on the highly interdisciplinary subject of protein interaction dynamics in a discussion-oriented meeting. The health relatedness of this application is that biomolecular interactions underlie all biological processes, and detailed knowledge of these processes is critical for understanding the molecular basis of disease and developing new therapies.