2010 Biomolecular Interactions & Methods GRC & GRS

描述(由申请人提供)：本提案寻求对戈登会议联合会议的部分支持：(1)戈登生物分子相互作用和方法研究会议(2010年1月17日至22日)；和(2)由博士后和博士后科学家组织的戈登研究研讨会(2010年1月16日至17日)。这两次会议将在德克萨斯州加尔维斯顿的同一地点举行，我们预计参加GRS的许多年轻科学家也将参加随后的GRC。这些会议的广泛和长期目标是促进我们对生物分子复合体的定量理解，以便我们可以表征生物功能、疾病和治疗干预的分子基础。2010年会议的主题是蛋白质相互作用动力学：理论、方法和实践，将探索表征蛋白质动力学的最新技术，蛋白质运动对结合相互作用的影响，以及生物系统中分子缔合的动力学。杰米·威廉姆森博士(斯克里普斯饰)将就他的开创性研究发表主旨演讲，该研究推动质谱学技术解决核糖体组装的当代问题。此外，会议包括九个科学会议，受邀发言者以及来自提交的摘要的报告；生动和高度互动的海报会议是对正式报告的补充。2010年，在主会议之前，将举行一次由细胞生物学和生物热力学领域的博士后和博士后实习生计划举行的周末会议。本次会议是戈登-凯南生物分子相互作用与方法研究生研究研讨会，将为该领域未来的领导者提供一个论坛，以演讲和海报的形式展示他们的工作，在一个共同和互动的环境中，这将为他们的整体GRC体验增加突出的价值。这次会议为科学家提供了一个独特的机会，让他们在一个以讨论为导向的会议上专注于蛋白质相互作用动力学这一高度跨学科的主题。这一应用与健康的相关性在于，生物分子相互作用是所有生物过程的基础，对这些过程的详细了解对于理解疾病的分子基础和开发新的治疗方法至关重要。

DESCRIPTION (provided by applicant): This proposal seeks partial support for joint Gordon Conference meetings: (1) the Gordon Research Conference on Biomolecular Interactions and Methods (Jan 17-22, 2010); and/or (2) its accompanying Gordon Research Symposium, which is organized by and for pre- and postdoctoral scientists (Jan 16-17, 2010). Both meetings will take place in Galveston, TX at the same venue, and we anticipate that many of the young scientists attending the GRS will also participate in the subsequent GRC. The broad and long-term goal of these meetings is to advance our quantitative understanding of biomolecular complexes so that we may characterize the molecular basis for biological functions, disease, and therapeutic intervention. The theme of the 2010 meetings, Protein Interaction Dynamics: Theory, Methods, and Practice, will explore the state-of-the-art for characterizing protein dynamics, the effect of protein motions on binding interactions, and the dynamics of molecular associations in biological systems. Dr. Jamie Williamson (Scripps) will present a keynote address on his pioneering research that pushes mass spectrometry technology to address the contemporary problem of ribosome assembly. In addition, the meeting includes nine scientific sessions with both invited speakers as well as presentations from submitted abstracts; lively and highly interactive poster sessions complement the formal presentations. In 2010, the main conference will be preceded by a weekend meeting planned by and for post-doctoral and pre-doctoral trainees in the field of cell biology and biothermodynamics. This meeting, the Gordon-Kenan Graduate Research Seminar on Biomolecular Interactions & Methods, will provide a forum for these future leaders in the field to present their work in talks and posters, in a collegial and interactive environment that will add outstanding value to their overall GRC experience. This meeting provides a unique opportunity for scientists to focus on the highly interdisciplinary subject of protein interaction dynamics in a discussion-oriented meeting. The health relatedness of this application is that biomolecular interactions underlie all biological processes, and detailed knowledge of these processes is critical for understanding the molecular basis of disease and developing new therapies.