Program of Molecular Biophysics

分子生物物理学专业

• 批准号: 10626851
• 负责人: Karen G. Fleming
• 金额: $ 84.89万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10626851
• 关键词: Biophysics; Molecular; programs

The Program in Molecular Biophysics (PMB) is a PhD training program at the Johns Hopkins University (JHU) spanning 4 schools and 13 primary departments. The focus of the PMB is on the physical-chemical and structural basis of life sciences, spanning from single-molecules to enormous macromolecular complexes and cellular systems. Experiment and computation are equally represented and closely intertwined, providing quantitative and rigorous training in quantitative and physical approaches to life sciences. The 37 training faculty in the PMB provide an interactive and collaborative training environment. The participating investigators run labs that are well funded and of moderate size, providing ample resources for research and student support, and close and carefully monitored trainee mentorship. Students are selected from a highly qualified pool of applicants using holistic admissions criteria, including dedication to science, research background, and perseverance, in addition to quantitative metrics. Through substantial efforts to encourage applications from URM students and assistance from a strong institutional diversity program, the PMB recruits a highly diverse and talented cohort of trainees. Each year, eight students matriculate into the PMB and are supported for two years by the training grant, with stipend and tuition supplements provided by Johns Hopkins University. First-year coursework is designed specifically for PMB trainees, using active-learning techniques, such as recently designed "Methods Modules," in which graduate-level theoretical instruction is directly linked to actual data collection and analysis. Other courses include fundamental aspects of biomolecules, scientific computing, along with statistics, data analysis, and reproducibility. From the beginning, soft-skill and career development are integrated in the curriculum; one example is a writing workshop organized in a collaboration between the PMB and the JHU Expository Writing Program. Through PMB career development activities along with JHU resources, these skills help propel PMB graduates to advanced positions in diverse biomedical science. Instruction and promotion of responsible conduct of research is interwoven throughout the entire training program. Progress with independent research is carefully monitored through internal committee assessment, as well as external mentor assessment. Through a mentoring mechanism that provides early guidance transitioning to independence, trainees perform high impact thesis research, resulting in a large number of publications, talks, and advanced positions following graduation. To continue to improve our training program, the PMB has instituted a comprehensive annual external assessment through partnership with JHU's Center for Educational Resources. The activities of the PMB are designed to contribute to fundamental scientific research and train responsible scientists who will become leaders in the biomedical workforce.

分子生物物理学项目（PMB）是约翰·霍普金斯大学的博士培训项目 (JHU) 涵盖 4 所学校和 13 个小学部。 PMB 的重点是物理化学和 生命科学的结构基础，从单分子到巨大的大分子复合物 蜂窝系统。实验和计算同等重要且紧密交织，提供 生命科学定量和物理方法的定量和严格培训。 37 培训 PMB 的教师提供互动和协作的培训环境。参与的 研究人员经营的实验室资金充足、规模适中，为研究和研究提供了充足的资源。 学生支持，以及密切和仔细监控的实习生指导。 学生是根据整体录取标准从高素质的申请者中挑选出来的， 除了定量指标之外，还包括对科学的奉献、研究背景和毅力。 通过大力鼓励URM学生的申请和强大的帮助 机构多元化计划中，PMB 招募了一批高度多元化且才华横溢的学员。每年， 八名学生入读 PMB，并获得为期两年的培训补助金、津贴和 约翰·霍普金斯大学提供的学费补助。第一年的课程是专门为 PMB 学员使用主动学习技术，例如最近设计的“方法模块”，其中 研究生水平的理论指导与实际数据收集和分析直接相关。其他课程 包括生物分子、科学计算的基本方面，以及统计学、数据分析和 再现性。从一开始，软技能和职业发展就融入到课程中；一 例如，PMB 和 JHU 说明文写作合作举办的写作研讨会 程序。通过 PMB 职业发展活动以及 JHU 资源，这些技能有助于推动 PMB 毕业生在各种生物医学科学领域担任高级职务。负责人的指导和晋升 研究的进行贯穿整个培训计划。 通过内部委员会评估仔细监控独立研究的进展，因为 以及外部导师评估。通过提供早期指导的指导机制 过渡到独立后，学员进行了高影响力的论文研究，产生了大量的 毕业后的出版物、演讲和高级职位。为了继续改进我们的培训计划， PMB 通过与 JHU 中心合作开展了全面的年度外部评估 教育资源。 PMB 的活动旨在为基础科学做出贡献 研究和培训负责任的科学家，他们将成为生物医学劳动力的领导者。

项目成果

Coupling cell shape and velocity leads to oscillation and circling in keratocyte galvanotaxis

细胞形状和速度的耦合导致角膜细胞趋电性的振荡和循环

• DOI: 10.1016/j.bpj.2022.11.021
• 发表时间: 2023
• 期刊: Biophysical Journal
• 影响因子: 3.4
• 作者: Nwogbaga, Ifunanya;Camley, Brian A.
• 通讯作者: Camley, Brian A.

Genetic screens in Saccharomyces cerevisiae identify a role for 40S ribosome recycling factors Tma20 and Tma22 in nonsense-mediated decay.

酿酒酵母的遗传筛选确定了 40S 核糖体回收因子 Tma20 和 Tma22 在无义介导的衰变中的作用。

• DOI: 10.1093/g3journal/jkad295
• 发表时间: 2024
• 期刊: G3 (Bethesda, Md.)
• 作者: Pacheco,Miguel;D'Orazio,KaroleN;Lessen,LauraN;Veltri,AnthonyJ;Neiman,Zachary;Loll-Krippleber,Raphael;Brown,GrantW;Green,Rachel
• 通讯作者: Green,Rachel

Progress toward Proteome-Wide Photo-Cross-Linking to Enable Residue-Level Visualization of Protein Structures and Networks In Vivo

• DOI: 10.1021/acs.analchem.3c01369
• 发表时间: 2023-06-21
• 期刊: ANALYTICAL CHEMISTRY
• 影响因子: 7.4
• 作者: Faustino，Anneliese M. M.;Sharma，Piyoosh;Fried，Stephen D. D.
• 通讯作者: Fried，Stephen D. D.

Phosphorylation at Ser65 modulates ubiquitin conformational dynamics.

Ser65 的磷酸化可调节泛素构象动力学。

• DOI: 10.1016/j.str.2023.05.006
• 发表时间: 2023
• 期刊: Structure (London, England : 1993)
• 作者: Yovanno,RemyA;Yu,Alvin;Wied,TylerJ;Lau,AlbertY
• 通讯作者: Lau,AlbertY