Program of Molecular Biophysics

分子生物物理学专业

• 批准号: 10626851
• 负责人: Karen G. Fleming
• 金额: $ 84.89万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10626851
• 关键词: Biophysics; Molecular; programs

The Program in Molecular Biophysics (PMB) is a PhD training program at the Johns Hopkins University (JHU) spanning 4 schools and 13 primary departments. The focus of the PMB is on the physical-chemical and structural basis of life sciences, spanning from single-molecules to enormous macromolecular complexes and cellular systems. Experiment and computation are equally represented and closely intertwined, providing quantitative and rigorous training in quantitative and physical approaches to life sciences. The 37 training faculty in the PMB provide an interactive and collaborative training environment. The participating investigators run labs that are well funded and of moderate size, providing ample resources for research and student support, and close and carefully monitored trainee mentorship. Students are selected from a highly qualified pool of applicants using holistic admissions criteria, including dedication to science, research background, and perseverance, in addition to quantitative metrics. Through substantial efforts to encourage applications from URM students and assistance from a strong institutional diversity program, the PMB recruits a highly diverse and talented cohort of trainees. Each year, eight students matriculate into the PMB and are supported for two years by the training grant, with stipend and tuition supplements provided by Johns Hopkins University. First-year coursework is designed specifically for PMB trainees, using active-learning techniques, such as recently designed "Methods Modules," in which graduate-level theoretical instruction is directly linked to actual data collection and analysis. Other courses include fundamental aspects of biomolecules, scientific computing, along with statistics, data analysis, and reproducibility. From the beginning, soft-skill and career development are integrated in the curriculum; one example is a writing workshop organized in a collaboration between the PMB and the JHU Expository Writing Program. Through PMB career development activities along with JHU resources, these skills help propel PMB graduates to advanced positions in diverse biomedical science. Instruction and promotion of responsible conduct of research is interwoven throughout the entire training program. Progress with independent research is carefully monitored through internal committee assessment, as well as external mentor assessment. Through a mentoring mechanism that provides early guidance transitioning to independence, trainees perform high impact thesis research, resulting in a large number of publications, talks, and advanced positions following graduation. To continue to improve our training program, the PMB has instituted a comprehensive annual external assessment through partnership with JHU's Center for Educational Resources. The activities of the PMB are designed to contribute to fundamental scientific research and train responsible scientists who will become leaders in the biomedical workforce.

在分子生物物理学（PMB）程序是在约翰霍普金斯大学博士培训计划 (JHU)横跨4所学校和13个小学部。PMB的重点是物理化学和 生命科学的结构基础，从单分子到巨大的大分子复合物， 蜂窝系统实验和计算是平等代表和密切交织在一起，提供 在生命科学的定量和物理方法方面进行定量和严格的培训。37训练 在港口及航运局的教师提供了一个互动和协作的培训环境。与会 研究人员管理的实验室资金充足，规模适中，为研究提供了充足的资源， 学生支持，以及密切和仔细监测的实习生指导。 学生是从一个高素质的申请人池使用整体录取标准， 包括对科学的奉献精神、研究背景和毅力，以及定量指标。 通过大力鼓励URM学生的申请和强大的援助， 机构的多样性计划，港口及航运局招募学员的高度多样化和有才华的队列。每年， 八名学生进入港口及航运局录取，并支持两年的培训补助金，与津贴， 约翰霍普金斯大学提供的学费补贴。第一年的课程是专门为 港口及航运局学员，使用主动学习技术，如最近设计的“方法模块”，其中 研究生一级的理论指导与实际数据收集和分析直接相关。其他课程 包括生物分子的基本方面，科学计算，沿着统计学，数据分析， 再现性从一开始，软技能和职业发展就融入了课程; 一个例子是在PMB和JHU Expository Writing之间合作组织的写作研讨会 程序.通过港口及航运局的职业发展活动沿着与JHU资源，这些技能有助于推动港口及航运局 毕业生在不同的生物医学科学的高级职位。负责人的指导和晋升 研究贯穿于整个培训计划。 独立研究的进展通过内部委员会评估进行仔细监测， 以及外部导师评估。通过提供早期指导的辅导机制 过渡到独立，学员进行高影响力的论文研究，导致大量的 出版物，会谈，并在毕业后的高级职位。为了继续改进我们的培训计划， 港口及航运局通过与JHU中心合作，制定了一项全面的年度外部评估 教育资源。PMB的活动旨在促进基础科学研究， 研究和培养负责任的科学家，他们将成为生物医学劳动力的领导者。

项目成果

Coupling cell shape and velocity leads to oscillation and circling in keratocyte galvanotaxis

细胞形状和速度的耦合导致角膜细胞趋电性的振荡和循环

• DOI: 10.1016/j.bpj.2022.11.021
• 发表时间: 2023
• 期刊: Biophysical Journal
• 影响因子: 3.4
• 作者: Nwogbaga, Ifunanya;Camley, Brian A.
• 通讯作者: Camley, Brian A.

Genetic screens in Saccharomyces cerevisiae identify a role for 40S ribosome recycling factors Tma20 and Tma22 in nonsense-mediated decay.

酿酒酵母的遗传筛选确定了 40S 核糖体回收因子 Tma20 和 Tma22 在无义介导的衰变中的作用。

• DOI: 10.1093/g3journal/jkad295
• 发表时间: 2024
• 期刊: G3 (Bethesda, Md.)
• 作者: Pacheco,Miguel;D'Orazio,KaroleN;Lessen,LauraN;Veltri,AnthonyJ;Neiman,Zachary;Loll-Krippleber,Raphael;Brown,GrantW;Green,Rachel
• 通讯作者: Green,Rachel

Progress toward Proteome-Wide Photo-Cross-Linking to Enable Residue-Level Visualization of Protein Structures and Networks In Vivo

• DOI: 10.1021/acs.analchem.3c01369
• 发表时间: 2023-06-21
• 期刊: ANALYTICAL CHEMISTRY
• 影响因子: 7.4
• 作者: Faustino，Anneliese M. M.;Sharma，Piyoosh;Fried，Stephen D. D.
• 通讯作者: Fried，Stephen D. D.

Phosphorylation at Ser65 modulates ubiquitin conformational dynamics.

Ser65 的磷酸化可调节泛素构象动力学。

• DOI: 10.1016/j.str.2023.05.006
• 发表时间: 2023
• 期刊: Structure (London, England : 1993)
• 作者: Yovanno,RemyA;Yu,Alvin;Wied,TylerJ;Lau,AlbertY
• 通讯作者: Lau,AlbertY