Program of Molecular Biophysics
分子生物物理学专业
基本信息
- 批准号:10626851
- 负责人:
- 金额:$ 84.89万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-01 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
The Program in Molecular Biophysics (PMB) is a PhD training program at the Johns Hopkins University
(JHU) spanning 4 schools and 13 primary departments. The focus of the PMB is on the physical-chemical and
structural basis of life sciences, spanning from single-molecules to enormous macromolecular complexes and
cellular systems. Experiment and computation are equally represented and closely intertwined, providing
quantitative and rigorous training in quantitative and physical approaches to life sciences. The 37 training
faculty in the PMB provide an interactive and collaborative training environment. The participating
investigators run labs that are well funded and of moderate size, providing ample resources for research and
student support, and close and carefully monitored trainee mentorship.
Students are selected from a highly qualified pool of applicants using holistic admissions criteria,
including dedication to science, research background, and perseverance, in addition to quantitative metrics.
Through substantial efforts to encourage applications from URM students and assistance from a strong
institutional diversity program, the PMB recruits a highly diverse and talented cohort of trainees. Each year,
eight students matriculate into the PMB and are supported for two years by the training grant, with stipend and
tuition supplements provided by Johns Hopkins University. First-year coursework is designed specifically for
PMB trainees, using active-learning techniques, such as recently designed "Methods Modules," in which
graduate-level theoretical instruction is directly linked to actual data collection and analysis. Other courses
include fundamental aspects of biomolecules, scientific computing, along with statistics, data analysis, and
reproducibility. From the beginning, soft-skill and career development are integrated in the curriculum; one
example is a writing workshop organized in a collaboration between the PMB and the JHU Expository Writing
Program. Through PMB career development activities along with JHU resources, these skills help propel PMB
graduates to advanced positions in diverse biomedical science. Instruction and promotion of responsible
conduct of research is interwoven throughout the entire training program.
Progress with independent research is carefully monitored through internal committee assessment, as
well as external mentor assessment. Through a mentoring mechanism that provides early guidance
transitioning to independence, trainees perform high impact thesis research, resulting in a large number of
publications, talks, and advanced positions following graduation. To continue to improve our training program,
the PMB has instituted a comprehensive annual external assessment through partnership with JHU's Center
for Educational Resources. The activities of the PMB are designed to contribute to fundamental scientific
research and train responsible scientists who will become leaders in the biomedical workforce.
在分子生物物理学(PMB)程序是在约翰霍普金斯大学博士培训计划
(JHU)横跨4所学校和13个小学部。PMB的重点是物理化学和
生命科学的结构基础,从单分子到巨大的大分子复合物,
蜂窝系统实验和计算是平等代表和密切交织在一起,提供
在生命科学的定量和物理方法方面进行定量和严格的培训。37训练
在港口及航运局的教师提供了一个互动和协作的培训环境。与会
研究人员管理的实验室资金充足,规模适中,为研究提供了充足的资源,
学生支持,以及密切和仔细监测的实习生指导。
学生是从一个高素质的申请人池使用整体录取标准,
包括对科学的奉献精神、研究背景和毅力,以及定量指标。
通过大力鼓励URM学生的申请和强大的援助,
机构的多样性计划,港口及航运局招募学员的高度多样化和有才华的队列。每年,
八名学生进入港口及航运局录取,并支持两年的培训补助金,与津贴,
约翰霍普金斯大学提供的学费补贴。第一年的课程是专门为
港口及航运局学员,使用主动学习技术,如最近设计的“方法模块”,其中
研究生一级的理论指导与实际数据收集和分析直接相关。其他课程
包括生物分子的基本方面,科学计算,沿着统计学,数据分析,
再现性从一开始,软技能和职业发展就融入了课程;
一个例子是在PMB和JHU Expository Writing之间合作组织的写作研讨会
程序.通过港口及航运局的职业发展活动沿着与JHU资源,这些技能有助于推动港口及航运局
毕业生在不同的生物医学科学的高级职位。负责人的指导和晋升
研究贯穿于整个培训计划。
独立研究的进展通过内部委员会评估进行仔细监测,
以及外部导师评估。通过提供早期指导的辅导机制
过渡到独立,学员进行高影响力的论文研究,导致大量的
出版物,会谈,并在毕业后的高级职位。为了继续改进我们的培训计划,
港口及航运局通过与JHU中心合作,制定了一项全面的年度外部评估
教育资源。PMB的活动旨在促进基础科学研究,
研究和培养负责任的科学家,他们将成为生物医学劳动力的领导者。
项目成果
期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Coupling cell shape and velocity leads to oscillation and circling in keratocyte galvanotaxis
细胞形状和速度的耦合导致角膜细胞趋电性的振荡和循环
- DOI:10.1016/j.bpj.2022.11.021
- 发表时间:2023
- 期刊:
- 影响因子:3.4
- 作者:Nwogbaga, Ifunanya;Camley, Brian A.
- 通讯作者:Camley, Brian A.
Genetic screens in Saccharomyces cerevisiae identify a role for 40S ribosome recycling factors Tma20 and Tma22 in nonsense-mediated decay.
酿酒酵母的遗传筛选确定了 40S 核糖体回收因子 Tma20 和 Tma22 在无义介导的衰变中的作用。
- DOI:10.1093/g3journal/jkad295
- 发表时间:2024
- 期刊:
- 影响因子:0
- 作者:Pacheco,Miguel;D'Orazio,KaroleN;Lessen,LauraN;Veltri,AnthonyJ;Neiman,Zachary;Loll-Krippleber,Raphael;Brown,GrantW;Green,Rachel
- 通讯作者:Green,Rachel
Progress toward Proteome-Wide Photo-Cross-Linking to Enable Residue-Level Visualization of Protein Structures and Networks In Vivo
- DOI:10.1021/acs.analchem.3c01369
- 发表时间:2023-06-21
- 期刊:
- 影响因子:7.4
- 作者:Faustino,Anneliese M. M.;Sharma,Piyoosh;Fried,Stephen D. D.
- 通讯作者:Fried,Stephen D. D.
Phosphorylation at Ser65 modulates ubiquitin conformational dynamics.
Ser65 的磷酸化可调节泛素构象动力学。
- DOI:10.1016/j.str.2023.05.006
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Yovanno,RemyA;Yu,Alvin;Wied,TylerJ;Lau,AlbertY
- 通讯作者:Lau,AlbertY
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Karen G. Fleming其他文献
A team of chaperones play to win in the bacterial periplasm
一组伴侣蛋白力争在细菌周质中发挥作用 。
- DOI:
10.1016/j.tibs.2024.03.015 - 发表时间:
2024-08-01 - 期刊:
- 影响因子:11.000
- 作者:
Taylor Devlin;Karen G. Fleming - 通讯作者:
Karen G. Fleming
Energetics of Dimeric FkpA Binding to a Native Unfolded Membrane Protein Client
- DOI:
10.1016/j.bpj.2019.11.2101 - 发表时间:
2020-02-07 - 期刊:
- 影响因子:
- 作者:
Michaela A. Roskopf;Dagan C. Marx;Karen G. Fleming - 通讯作者:
Karen G. Fleming
FkpA enhances outer membrane protein folding using an extensive interaction interface
- DOI:
10.1016/j.bpj.2023.11.1353 - 发表时间:
2024-02-08 - 期刊:
- 影响因子:
- 作者:
Taylor A. Devlin;Dagan C. Marx;Anneliese Faustino;Michaela Roskopf;Stephen D. Fried;Karen G. Fleming - 通讯作者:
Karen G. Fleming
Towards Understanding How Water Modulates Membrane Protein Stability
- DOI:
10.1016/j.bpj.2019.11.325 - 发表时间:
2020-02-07 - 期刊:
- 影响因子:
- 作者:
Dagan C. Marx;Karen G. Fleming - 通讯作者:
Karen G. Fleming
Measuring The Energetic Cost Of Burying An Arginine Sidechain Into A Lipid Bilayer Using A Transmembrane Protein
- DOI:
10.1016/j.bpj.2008.12.1766 - 发表时间:
2009-02-01 - 期刊:
- 影响因子:
- 作者:
Preston Moon;Karen G. Fleming - 通讯作者:
Karen G. Fleming
Karen G. Fleming的其他文献
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{{ truncateString('Karen G. Fleming', 18)}}的其他基金
2010 Biomolecular Interactions & Methods GRC & GRS
2010 生物分子相互作用
- 批准号:
7800232 - 财政年份:2009
- 资助金额:
$ 84.89万 - 项目类别:
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Cellular & Molecular Immunology
- 批准号:30824806
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