Biobehavioral characterization of infant rhesus monkeys

描述(由申请人提供)：三十年来对啮齿动物、非人灵长类和人类的心理生物学研究证明，在气质、情绪性、行为和生理反应以及个性方面存在个体差异，我们称之为生物行为组织。这些特征会影响个体对环境的适应方式，有证据表明，动物适应的质量与心理和身体健康指数有关。在加州国家灵长类动物研究中心，我们开发了一个项目来评估幼年恒河猴的生物行为组织。我们的方案包括a)收集几种情况下的行为数据，以评估记忆、对轻微挑战的反应以及与新对象互动的意愿；b)对两个神经精神疾病基因5-羟色胺转运体和单胺氧化酶-A的启动子区域的多态进行基因分型；c)评估下丘脑-垂体-肾上腺系统的调节；以及d)测量常规血液学参数。来自该资源的数据可通过网络界面提供给CNPRC的所有服务和科学工作人员，以用于科学和群体管理目的。在目前的申请中，我们提出了以下具体目标：继续每年对大约300只幼年恒河猴进行生物行为评估，并在每年完成数据处理后，通过我们的网页将这些数据提供给合格的科学和管理人员；继续我们正在进行的努力，以确定我们的BBA计划中前参与者的属性，这些属性面临着适应圈养环境不良的风险，按 使用现有的BBA数据统计方法，建立与不良结果相关的个人档案，帮助群体管理人员预防健康、行为、生殖和社会问题；继续开发比我们目前的程序更短、更简单、更易于管理的标准化测试，同时满足我们结果测量的相同可靠性和预测有效性标准。 公共卫生相关性(由申请者提供)：该项目将为与健康相关的研究改进非人类灵长类模型，并将提供一个数据库，该数据库将唯一能够为个性化医学的灵长类模型的发展做出贡献。

DESCRIPTION (provided by applicant): Three decades of psychobiological research with rodents, nonhuman primates, and humans have documented the existence of individual differences in temperament, emotionality, behavioral and physiological reactivity, and personality, which we refer to as biobehavioral organization. These characteristics influence an individual's style of adaptation to its environment, and evidence shows that the quality of the animal's adaptations is associated with indices of psychological and physical health. At the California National Primate Research Center, we have developed a program to assess biobehavioral organization in infant rhesus monkeys. Our protocol includes a) collecting behavioral data in several situations designed to assess memory, responsiveness to mild challenges, and willingness to interact with novel objects; b) genotyping for polymorphisms in the promoter regions of two neuropsychiatric genes, the serotonin transporter and monoamine oxidase-A; c) assessing regulation of the hypothalamic-pituitary-adrenal system; and d) measuring routine hematologic parameters. Data from this resource are available to all CNPRC service and scientific staff via a web interface, to use for scientific and colony management purposes. In the current application, we propose the following specific aims: to continue performing our BioBehavioral Assessment on approximately 300 infant rhesus monkeys per year and to make these data available to qualified scientific and management staff through our web page as soon as the processing of the data is complete each year; to continue our ongoing efforts to identify the attributes of former participants in our BBA program that are at risk for poor adaptation to a captive environment as indexed by measures of chronic illness, abnormal behaviors, poor reproduction, and aberrant social function; to use existing statistical methods on our BBA data to establish individual profiles associated with poor outcomes as aids to colony management personnel to prevent health, behavioral, reproductive, and social problems; to continue to develop standardized tests that are shorter, simpler, and easier to administer than our current procedure, yet meet the same standards of reliability and predictive validity for our outcome measures. PUBLIC HEALTH RELEVANCE (provided by applicant): This project will result in improved nonhuman primate models for health-related research, and will provide a database that will be uniquely able to contribute to the development of primate models of personalized medicine.