SINGLE CRYSTAL XAS OF CUSF

CUSF 的单晶 XAS

• 批准号: 8170051
• 负责人: James E. Penner-Hahn
• 金额: $ 0.34万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170051
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Disease; Funding; Grant; Institution; Measurement; Metal Binding Site; Metals; Proteins; Research; Research Personnel; Resolution; Resources; Site; Solutions; Source; Structure; United States National Institutes of Health; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Initial crystallographic measurements suggest an unprecedented metal binding site in the Cu efflux protein CusF, with a novel organometallic structure. However, the crystal has modest resolution and more importantly is disordered near the metal, with only partial metal-site occupancy. A combination of solution and single crystal XAS will be used to provide detailed local structural information for the apparently unprecedented metal site.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 初始晶体学测量表明，Cu外排蛋白CUSF中具有前所未有的金属结合位点，具有新型的有机金属结构。但是，晶体具有适度的分辨率，更重要的是在金属附近陷入混乱，只有部分金属位置占用率。溶液和单晶XAS的组合将用于为明显前所未有的金属位点提供详细的局部结构信息。