Mass Spectometry Facility Core

MS设备核心的研究和开发功能是帮助用户开发新的分析方法。这些通常涉及测量内源性代谢物的定量技术的发展，改善样品电离的方法的发展，以及高性能UPLC方法的发展。如果这些内部项目的目的是使更多的调查人员受益，并提高设施核心工作人员的技术技能，则这些内部项目是免费进行的。 质谱学(MS)设施核心的任务是为中心调查人员和P30 EHS核心中心的试点和其他支持的项目提供具有成本效益的、最先进的仪器和分析专业知识。该设施核心是利用大学范围内的质谱学设施中的技术人员和仪器设施的专业服务核心之一，用于鉴定、定量和表征小分子反应产物，例如二十碳和氧化脂质(1-3)、DNA碱基加合物(4-7)、修饰寡核苷酸(8-10)的鉴定和表征，以及外源有毒物质的代谢激活(1，11-13)。

The research and development function of the MS Facility Core is to assist users with development of novel analytical methods. These generally relate to development of quantitative techniques to measure endogenous metabolites, development of methods to improve sample ionization and development of high performance UPLC methods. These internal projects are undertaken at no expense to users if they are intended to benefit a larger group of investigators and improve the technical skills of the facility core staff. The mission of the Mass Spectrometry (MS) Facility Core is to provide cost effective, state-of-the-art instrumentation and analytical expertise to Center Investigators and pilot and other supported projects in the P30 EHS Core Center This facility core is among the specialized service cores utilizing the technical personnel and instrument facilities located in the university-wide mass spectrometry facility and is used for identification, quantitation, and characterization of small molecule reaction products, e.g. eicosanoids and oxidized lipids (1-3), DNA base adducts (4-7), identification and characterization of modified oligonucleotides (8-10), and metabolic activation of xenobiotic toxicants (1, 11-13).