Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk

未产妇早产：未充分研究的高危人群

• 批准号: 7790819
• 负责人: HYAGRIV N SIMHAN
• 金额: $ 21.55万
• 依托单位: MAGEE-WOMEN'S RES INST AND FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-10 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7790819
• 关键词: Address; Affect; Anti-Inflammatory Agents; Anti-inflammatory; Area; Bacterial Vaginosis; Biological Process; Birth; Black race; Characteristics; Charge; Clinical; Clinical Research; Cohort Studies; Collaborations; Collection; Data; Development; Diagnostic tests; Discipline of obstetrics; Enrollment; Environment; Environmental Exposure; Environmental Risk Factor; Epidemiology; Epigenetic Process; Etiology; Faculty; Fetus; First Pregnancy Trimester; Future; Genes; Genetic; Genetic Polymorphism; Genital system; Genomics; Genotype; Growth; Hospitals; Image; Immunity; Incidence; Infection; Inflammation; Inflammatory; Intervention; Intervention Studies; Knowledge; Lead; Mediating; Morbidity - disease rate; Multicenter Studies; Nature; Neonatal Mortality; Operations Research; Pathology; Patient Self-Report; Patients; Physiological; Placentation; Population; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Prenatal care; Prevention; Proteomics; Public Health; Race; Recording of previous events; Research Infrastructure; Resources; Risk; Sampling; Sampling Studies; Screening procedure; Site; System; Technical Expertise; Ultrasonography; Universities; Vitamin D; Woman; base; cigarette smoking; clinical research site; cohort; cytokine; design; experience; fetal; gene environment interaction; maternal cigarette smoking; mortality; public health relevance; response

DESCRIPTION (provided by applicant): The purpose of this proposal is to demonstrate the capabilities of the University of Pittsburgh to participate as a Clinical site in a NICHD-sponsored network addressing Preterm Birth in Nulliparous Women ("Nullipara Network"). Our site has been a long-standing track record of successful contribution to single and multicenter studies of adverse pregnancy outcomes for more than 20 years. We are particularly well suited to be a clinical site in this Network because of our volume, clinical research infrastructure and track record, basic and translational experience and expertise, and specialized resources that we can bring to such a multicenter venture. Approximately 10,000 women deliver per year at Magee-Womens Hospital, and 85% of these women initiate prenatal care in our system at < 10 weeks. Through our extensive research infrastructure, we have successfully enrolled women in the first trimester, followed them longitudinally through pregnancy to delivery, with serial collection and processing of biological samples and ultrasound data. Our research operation is ideal for cohort studies such as that to be conducted by the Nullipara Network. Additionally, our site brings unique content and technical expertise in clinical obstetrics, fetal imaging, genomics and proteomics, placental pathology, and epidemiology. All of these areas represented among our faculty, and we have a long and successful history of productive collaboration. The Nullipara Network is charged with 4 objectives: 7 Determine maternal characteristics that influence and/or predict adverse pregnancy outcome to include genetics, epigenetics, physiological response to pregnancy, and the interaction with environmental exposures 7 Identify specific aspects of placental development and function that lead to adverse pregnancy outcome 7 Characterize genetic, growth, and developmental parameters of the fetus that are associated with adverse pregnancy outcome 7 Determine whether assessments and potential interventions during pregnancy may provide useful information to reduce the incidence of adverse pregnancy outcome Our site has the track record, patient base, research infrastructure, content and technical expertise to design and execute a cohort study that achieves all four of these objectives. PUBLIC HEALTH RELEVANCE: At least 12% of women in their first pregnancy will have a preterm delivery, with associated high rates of neonatal mortality and long term morbidity. Because nulliparas are a large proportion of pregnant women, understanding the mechanism for future prevention of preterm birth and other related adverse pregnancy outcomes will have a significant public health impact.

描述（由申请人提供）：本提案的目的是展示匹兹堡大学作为临床中心参与 NICHD 赞助的解决未产妇早产问题的网络（“Nullipara 网络”）的能力。 20 多年来，我们的网站一直为不良妊娠结局的单中心和多中心研究做出了成功贡献。我们特别适合成为该网络中的临床中心，因为我们可以为这样一个多中心企业带来我们的数量、临床研究基础设施和跟踪记录、基础和转化经验和专业知识以及专业资源。每年约有 10,000 名妇女在 Magee-Womens Hospital 分娩，其中 85% 的妇女在出生后 10 周内就开始在我们的系统中进行产前护理。通过我们广泛的研究基础设施，我们成功地招募了妊娠早期的女性，从怀孕到分娩对她们进行纵向跟踪，连续收集和处理生物样本和超声数据。我们的研究运作非常适合队列研究，例如由 Nullipara 网络进行的研究。此外，我们的网站还提供临床产科、胎儿成像、基因组学和蛋白质组学、胎盘病理学和流行病学方面的独特内容和技术专业知识。所有这些领域都由我们的教师代表，我们有着悠久而成功的富有成效的合作历史。 Nullipara 网络负责 4 个目标： 7 确定影响和/或预测不良妊娠结局的母体特征，包括遗传学、表观遗传学、对妊娠的生理反应以及与环境暴露的相互作用 7 确定导致不良妊娠结局的胎盘发育和功能的具体方面 7 描述与不良妊娠结局相关的胎儿遗传、生长和发育参数的特征 7 确定是否评估和潜在的影响 怀孕期间的干预措施可能会提供有用的信息，以减少不良妊娠结局的发生率。我们的网站拥有跟踪记录、患者基础、研究基础设施、内容和技术专长，可以设计和执行一项队列研究，以实现所有这四个目标。 公共卫生相关性：至少 12% 的首次妊娠女性会发生早产，并导致新生儿死亡率和长期发病率较高。由于未产妇在孕妇中所占比例很大，了解未来预防早产和其他相关不良妊娠结局的机制将对公共健康产生重大影响。