Maternal-Fetal Medicine Units (MFMU) Networks

母胎医学单位 (MFMU) 网络

• 批准号: 10379312
• 负责人: HYAGRIV N SIMHAN
• 金额: $ 31.41万
• 依托单位: MAGEE-WOMEN'S RES INST AND FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10379312
• 关键词: Address; Area; Awareness; Biological; COVID-19; Clinical; Clinical Protocols; Clinical Research; Clinical Research Protocols; Collaborations; Collection; Data; Demography; Development; Discipline of obstetrics; Enrollment; Ensure; Epidemiology; Faculty; Fetal Growth; First Pregnancy Trimester; Genomics; Gynecology; High-Risk Pregnancy; Hospitals; Image; Infrastructure; Institution; Intervention; Maternal complication; Maternal-Fetal Medicine Units Network; Maternal-fetal medicine; Medical center; Mission; Multicenter Studies; National Institute of Child Health and Human Development; Neonatal; Newborn Infant; Obstetric Fetal Pharmacology; Participant; Pathology; Patient Recruitments; Patients; Perinatal; Population; Pravastatin; Pregnancy; Premature Birth; Prenatal care; Privatization; Proteomics; Protocols documentation; Randomized; Recording of previous events; Registries; Reproductive Sciences; Research; Research Infrastructure; Resources; Safety; Sampling; Services; Site; Structure; System; Technical Expertise; United States; Universities; University Hospitals; Woman; adverse pregnancy outcome; base; clinical center; clinical implementation; clinical research site; design; experience; fetal; follow-up; high risk; infant morbidity; multidisciplinary; postnatal; premature; success; ultrasound; willingness

The purpose of this proposal is to summarize the resources at Magee Womens Hospital of the University of Pittsburgh Medical Center (UPMC) and to demonstrate how we will continue to contribute meaningfully to the mission and objectives of the NICHD-sponsored Maternal-Fetal Medicine Units Network. Our Unit has been an active participant in single- and multi-center observational and interventional clinical studies for three decades, including the NuMom2b network, and the Obstetric-Fetal Pharmacology Research network, and the MFMU Network. Our track record establishes that we have demonstrated our willingness to cooperate with other institutions and the NICHD in the development and implementation of clinical research protocols. We have been active participants in every aspect of multicenter networks. We have proposed protocols, have served on subcommittees of other protocols, have served on administrative subcommittees, and have served as site visitors to evaluate other centers. We have effectively recruited patients and have provided intellectual input in the development of new projects as well as the implementation of protocols from our center and from others. The obstetrical unit at the University of Pittsburgh is one of the largest private academic obstetrical services in the United States with over 10,000 deliveries annually. Approximately 40% of our patients are deemed to be high risk prior to labor. The demography of our population, detailed in this application, and our high enrollment rates help ensure that results of Network studies are widely applicable across a diverse spectrum of subjects. In this proposal we will: (1) describe our experience, infrastructure, and track record of participation in single-center and multicenter studies of adverse pregnancy outcome; (2) demonstrate our ability to enroll and provide maternal and newborn follow-up to subjects enrolled in MFMU trials; and (3) delineate our unique suitability in terms of technical and multidisciplinary content expertise to address the objectives of the MFMU Network. We are enthusiastic about continuing to contribute to the success of the MFMU Network and its continued pre-eminence in clinical research.

本提案的目的是总结 Magee 妇女医院的资源 匹兹堡大学医学中心 (UPMC) 的并展示我们将如何 继续为 NICHD 赞助的使命和目标做出有意义的贡献 母胎医学单位网络。我们单位一直积极参与单一和 三十年来的多中心观察和介入临床研究，包括 NuMom2b 网络和产科-胎儿药理学研究网络，以及 MFMU 网络。我们的业绩记录表明我们已经表明我们愿意 与其他机构和 NICHD 合作制定和实施 临床研究协议。我们一直积极参与多中心的各个方面 网络。我们提出了协议，曾在其他协议的小组委员会任职， 在行政小组委员会任职，并作为网站访问者评估其他 中心。我们有效地招募了患者并提供了智力投入 新项目的开发以及我们中心协议的实施 来自其他人。匹兹堡大学的产科单位是最大的私立产科单位之一 美国的学术产科服务，每年分娩超过 10,000 例。 我们大约 40% 的患者在临产前被认为具有高风险。这 本申请中详细介绍了我们的人口统计数据以及我们的高入学率 有助于确保网络研究的结果广泛适用于不同的领域 科目范围。在此提案中，我们将：（1）描述我们的经验、基础设施、 以及参与不良反应的单中心和多中心研究的记录 妊娠结局； (2) 证明我们有能力招募和提供孕产妇和 对参加 MFMU 试验的受试者进行新生儿随访； (3) 描绘出我们独特的 技术和多学科内容专业知识方面的适用性，以解决 MFMU 网络的目标。我们热衷于继续为该领域做出贡献 MFMU 网络的成功及其在临床研究中持续的卓越地位。