Maternal-Fetal Medicine Unit (MFMU) Network Clinical Centers

母胎医学中心 (MFMU) 网络临床中心

• 批准号: 10682149
• 负责人: HYAGRIV N SIMHAN
• 金额: $ 33.31万
• 依托单位: MAGEE-WOMEN'S RES INST AND FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2030-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10682149
• 关键词: Address; Area; Biological; Clinical; Clinical Research; Collaborations; Collection; Data; Demography; Discipline of obstetrics; Enrollment; Epidemiology; Faculty; First Pregnancy Trimester; Genomics; Gynecology; Hospitals; Image; Individual; Infrastructure; Institution; Intervention; Lactation; Maternal-Fetal Medicine Units Network; Mission; Multi-Institutional Clinical Trial; Multicenter Studies; National Institute of Child Health and Human Development; Neonatal; Newborn Infant; Observational Study; Obstetric pharmacology; Pathology; Patients; Perinatal; Persons; Population; Pregnancy; Premature Birth; Prenatal care; Proteomics; Protocols documentation; Randomized; Recording of previous events; Reproducibility; Reproductive Sciences; Research; Research Infrastructure; Resources; Sampling; Site; Structure; System; Technical Expertise; Universities; Woman; Work; adverse pregnancy outcome; base; clinical center; clinical practice; clinical research site; design; experience; fetal; follow-up; high risk; multidisciplinary; patient population; postnatal; pregnant; success; ultrasound

The purpose of this proposal is to demonstrate the capabilities of the University of Pittsburgh to continue to participate as a clinical site in the Eunice Kennedy Shriver NICHD Maternal-Fetal Medicine Units Network (MFMUN). We are particularly well suited to be a clinical site in this Network because of our delivery volume; clinical research infrastructure and track record; basic and translational experience and expertise; and specialized resources that we can bring to the Network. Approximately 10,000 women deliver per year at Magee-Womens Hospital, and 75% of these women initiate prenatal care in our system at < 14 weeks. Our site, a large volume delivery-perinatal center under a unified administrative structure, is ideal for participation in the MFMU Network. Through our extensive research infrastructure, we have successfully enrolled women as early as the first trimester, followed them longitudinally through pregnancy to delivery, conducted randomized clinical interventions, and have performed serial collection and processing of biological samples and ultrasound data. We also have demonstrated success in longitudinal postnatal maternal and neonatal follow-up. The demography of our population allows us to contribute uniquely to the study of preterm birth and other adverse pregnancy outcomes. Additionally, our site brings unique content and technical expertise in clinical obstetrics, fetal imaging, genomics and proteomics, placental pathology, and epidemiology. All these areas are represented among our faculty, and we have a long and successful history of research collaboration, within our institution and via multicenter studies. In this application, we aim to: 1. To describe our experience, infrastructure, and track record of participation in single- center and multicenter studies of adverse pregnancy outcomes 2. To demonstrate our ability to enroll a diverse patient population and demonstrate our ability to continue to enroll and provide maternal and newborn follow-up to subjects for ongoing and new MFMU studies 3. To delineate our unique suitability in terms of technical and multidisciplinary content expertise to address the objectives of the MFMU Network.

这项提议的目的是证明匹兹堡大学有能力 继续作为临床现场参加尤尼斯·肯尼迪·施莱弗NICHD母婴 医疗单位网络(MFMUN)。我们特别适合作为这一地区的临床地点 由于我们的供货量而建立的网络；临床研究基础设施和记录；基础 和翻译经验和专业知识；以及我们可以带给 网络。每年约有10,000名妇女在玛吉-妇女医院分娩，其中75% 这些妇女在14周时开始在我们的系统中进行产前护理。我们的网站，数量很大 分娩-围产期中心在统一的管理结构下，是参与 MFMU网络。通过我们广泛的研究基础设施，我们成功地招收了 妇女早在怀孕的前三个月，就一直跟踪她们直到怀孕 分娩，进行随机临床干预，并进行系列收集和 生物样品和超声数据的处理。我们还在以下方面取得了成功 产后母亲和新生儿的纵向随访。我们人口的人口结构 使我们能够对早产和其他不良妊娠的研究做出独特的贡献 结果。此外，我们的网站还提供了临床方面的独特内容和技术专长 产科、胎儿成像、基因组学和蛋白质组学、胎盘病理学和流行病学。全 这些领域在我们的教职员工中都有代表，我们有着悠久而成功的历史 研究协作，在我们机构内并通过多中心研究。在此应用程序中，我们 目标：1.描述我们的经验、基础设施和参与单一- 不良妊娠结局的中心和多中心研究2.证明我们有能力 招募不同的患者群体，并展示我们继续登记和提供 对正在进行的和新的MFMU研究对象的孕产妇和新生儿的随访3.描述 我们在技术和多学科内容专业知识方面的独特适用性 阐述MFMU网络的目标。