NICHD Maternal-Fetal Medicine Units (MFMU) Network

NICHD 母胎医学中心 (MFMU) 网络

• 批准号: 9901625
• 负责人: HYAGRIV N SIMHAN
• 金额: $ 27.2万
• 依托单位: MAGEE-WOMEN'S RES INST AND FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9901625
• 关键词: Address; Area; Biological; Clinical; Clinical Protocols; Clinical Research; Clinical Research Protocols; Collaborations; Collection; Data; Demography; Development; Discipline of obstetrics; Enrollment; Ensure; Epidemiology; Faculty; Fetal Growth; First Pregnancy Trimester; Genomics; Gynecology; High-Risk Pregnancy; Hospitals; Image; Infrastructure; Institution; Intervention; Maternal-Fetal Medicine Units Network; Maternal-fetal medicine; Medical center; Mission; Multicenter Studies; National Institute of Child Health and Human Development; Neonatal; Newborn Infant; Obstetric Fetal Pharmacology; Participant; Pathology; Patient Recruitments; Patients; Perinatal; Population; Pregnancy; Premature Birth; Prenatal care; Privatization; Proteomics; Protocols documentation; Randomized; Recording of previous events; Research; Research Infrastructure; Resources; Safety; Sampling; Science; Services; Site; Structure; System; Technical Expertise; Ultrasonography; United States; Universities; University Hospitals; Woman; adverse pregnancy outcome; base; clinical center; clinical implementation; clinical research site; design; expectation; experience; fetal; follow-up; high risk; infant morbidity; multidisciplinary; postnatal; public health relevance; reproductive; success; willingness

 DESCRIPTION (provided by applicant): The purpose of this proposal is to summarize the resources at Magee Womens Hospital of the University of Pittsburgh Medical Center (UPMC) and to demonstrate how we will contribute meaningfully to the mission and objectives of the NICHD-sponsored Maternal- Fetal Medicine Units Network. Our Unit has been an active participant in single- and multi-center observational and interventional clinical studies for three decades, including the NuMom2b network, and the Obstetric-Fetal Pharmacology Research network, and previous iterations of the MFMU Network. Our track record establishes that we have demonstrated our willingness to cooperate with other institutions and the NICHD in the development and implementation of clinical research protocols. We have been active participants in every aspect of multicenter networks. We have proposed protocols, have served on subcommittees of other protocols, have served on administrative subcommittees, and have served as site visitors to evaluate other centers. We have effectively recruited patients and have provided intellectual input in the development of new projects as well as the implementation of protocols from our center and from others. The obstetrical unit at the University of Pittsburgh is one of the largest private academic obstetrical services in the United States with over 10,000 deliveries annually. Approximately 40% of our patients are deemed to be high risk prior to labor. The demography of our population, detailed in this application, and our high enrollment rates help ensure that results of Network studies are widely applicable across a diverse spectrum of subjects. In this proposal we will: (1) describe our experience, infrastructure, and track record o participation in single-center and multicenter studies of adverse pregnancy outcome; (2) demonstrate our ability to enroll and provide maternal and newborn follow-up to subjects enrolled in MFMU trials; and (3) delineate our unique suitability in terms of technical and multidisciplinary content expertise to address the objectives of the MFMU Network. We are enthusiastic about contributing to the success of the MFMU Network and its continued pre-eminence in clinical research

 描述（由申请人提供）：本提案的目的是总结匹兹堡大学医学中心（UPMC）Magee妇女医院的资源，并证明我们将如何为NICHD赞助的孕产妇-胎儿医学单位网络的使命和目标做出有意义的贡献。我们单位一直积极参与单中心和多中心观察性和干预性临床研究， 数十年来，包括NuMom 2b网络，产科-胎儿药理学研究网络，以及MFMU网络的先前迭代。我们的记录表明，我们愿意与其他机构和NICHD合作制定和实施临床研究方案。我们一直积极参与多中心网络的各个方面。我们提出了协议，曾担任其他协议的小组委员会，曾担任行政小组委员会，并担任现场访问者，以评估其他中心。我们有效地招募了患者，并为新项目的开发以及我们中心和其他机构的协议的实施提供了智力投入。匹兹堡大学的产科是美国最大的私立学术产科服务机构之一，每年接生超过10 000例。大约40%的患者在分娩前被认为是高风险的。我们的人口统计学，在此应用程序中详细说明，我们的高入学率有助于确保网络研究的结果广泛适用于各种学科。在本提案中，我们将：（1）描述我们参与不良妊娠结局单中心和多中心研究的经验、基础设施和跟踪记录;（2）证明我们有能力招募并为MFMU试验中招募的受试者提供孕产妇和新生儿随访;（3）描述我们在技术和多学科内容专业知识方面的独特适用性，以实现MFMU网络的目标。我们热衷于为MFMU网络的成功及其在临床研究中的持续领先地位做出贡献