Maternal-Fetal Medicine Units (MFMU) Networks

本提案的目的是总结马吉妇女医院的资源 匹兹堡大学医学中心（UPMC），并证明我们将如何 继续为NICHD的使命和目标做出有意义的贡献， 母胎医学单位网络。我们的单位一直是一个积极的参与者， 三十年来的多中心观察性和干预性临床研究，包括 NuMom 2b网络和产科-胎儿药理学研究网络，以及 MFMU网络。我们的记录表明，我们愿意 与其他机构和NICHD合作，制定和实施 临床研究方案。我们一直积极参与多中心的各个方面， 网络.我们提出了议定书，在其他议定书的小组委员会任职， 担任行政小组委员会成员，并担任网站访问者，以评估其他 中心.我们有效地招募了病人，并在 新项目的开发以及我们中心的协议的实施， 从其他人那里。匹兹堡大学的产科是美国最大的私立产科之一， 学术产科服务在美国与超过10,000交付每年。 大约40%的患者在分娩前被认为是高风险的。的 我们的人口统计学，在这个应用程序中详细说明，以及我们的高入学率 有助于确保网络研究的结果广泛适用于各种 主题的光谱。在本提案中，我们将：（1）描述我们的经验，基础设施， 参与不良反应单中心和多中心研究的跟踪记录 妊娠结局;（2）证明我们有能力招募并提供孕产妇和 新生儿随访参加MFMU试验的受试者;（3）描述我们独特的 在技术和多学科内容专业知识方面的适用性，以解决 MFMU网络的目标。我们热衷于继续为 MFMU网络的成功及其在临床研究中的持续卓越。

The purpose of this proposal is to summarize the resources at Magee Womens Hospital of the University of Pittsburgh Medical Center (UPMC) and to demonstrate how we will continue to contribute meaningfully to the mission and objectives of the NICHD-sponsored Maternal-Fetal Medicine Units Network. Our Unit has been an active participant in single- and multi-center observational and interventional clinical studies for three decades, including the NuMom2b network, and the Obstetric-Fetal Pharmacology Research network, and the MFMU Network. Our track record establishes that we have demonstrated our willingness to cooperate with other institutions and the NICHD in the development and implementation of clinical research protocols. We have been active participants in every aspect of multicenter networks. We have proposed protocols, have served on subcommittees of other protocols, have served on administrative subcommittees, and have served as site visitors to evaluate other centers. We have effectively recruited patients and have provided intellectual input in the development of new projects as well as the implementation of protocols from our center and from others. The obstetrical unit at the University of Pittsburgh is one of the largest private academic obstetrical services in the United States with over 10,000 deliveries annually. Approximately 40% of our patients are deemed to be high risk prior to labor. The demography of our population, detailed in this application, and our high enrollment rates help ensure that results of Network studies are widely applicable across a diverse spectrum of subjects. In this proposal we will: (1) describe our experience, infrastructure, and track record of participation in single-center and multicenter studies of adverse pregnancy outcome; (2) demonstrate our ability to enroll and provide maternal and newborn follow-up to subjects enrolled in MFMU trials; and (3) delineate our unique suitability in terms of technical and multidisciplinary content expertise to address the objectives of the MFMU Network. We are enthusiastic about continuing to contribute to the success of the MFMU Network and its continued pre-eminence in clinical research.