Maternal-Fetal Medicine Units (MFMU) Networks

母胎医学单位 (MFMU) 网络

• 批准号: 10254761
• 负责人: HYAGRIV N SIMHAN
• 金额: $ 30.1万
• 依托单位: MAGEE-WOMEN'S RES INST AND FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10254761
• 关键词: Address; Area; Awareness; Biological; COVID-19; Clinical; Clinical Protocols; Clinical Research; Clinical Research Protocols; Collaborations; Collection; Data; Demography; Development; Discipline of obstetrics; Enrollment; Ensure; Epidemiology; Faculty; Fetal Growth; First Pregnancy Trimester; Genomics; Gynecology; High-Risk Pregnancy; Hospitals; Image; Infrastructure; Institution; Intervention; Maternal complication; Maternal-Fetal Medicine Units Network; Maternal-fetal medicine; Medical center; Mission; Multicenter Studies; National Institute of Child Health and Human Development; Neonatal; Newborn Infant; Obstetric Fetal Pharmacology; Participant; Pathology; Patient Recruitments; Patients; Perinatal; Population; Pravastatin; Pregnancy; Premature Birth; Prenatal care; Privatization; Proteomics; Protocols documentation; Randomized; Recording of previous events; Registries; Reproductive Sciences; Research; Research Infrastructure; Resources; Safety; Sampling; Services; Site; Structure; System; Technical Expertise; Ultrasonography; United States; Universities; University Hospitals; Woman; adverse pregnancy outcome; base; clinical center; clinical implementation; clinical research site; design; experience; fetal; follow-up; high risk; infant morbidity; multidisciplinary; postnatal; premature; success; willingness

The purpose of this proposal is to summarize the resources at Magee Womens Hospital of the University of Pittsburgh Medical Center (UPMC) and to demonstrate how we will continue to contribute meaningfully to the mission and objectives of the NICHD-sponsored Maternal-Fetal Medicine Units Network. Our Unit has been an active participant in single- and multi-center observational and interventional clinical studies for three decades, including the NuMom2b network, and the Obstetric-Fetal Pharmacology Research network, and the MFMU Network. Our track record establishes that we have demonstrated our willingness to cooperate with other institutions and the NICHD in the development and implementation of clinical research protocols. We have been active participants in every aspect of multicenter networks. We have proposed protocols, have served on subcommittees of other protocols, have served on administrative subcommittees, and have served as site visitors to evaluate other centers. We have effectively recruited patients and have provided intellectual input in the development of new projects as well as the implementation of protocols from our center and from others. The obstetrical unit at the University of Pittsburgh is one of the largest private academic obstetrical services in the United States with over 10,000 deliveries annually. Approximately 40% of our patients are deemed to be high risk prior to labor. The demography of our population, detailed in this application, and our high enrollment rates help ensure that results of Network studies are widely applicable across a diverse spectrum of subjects. In this proposal we will: (1) describe our experience, infrastructure, and track record of participation in single-center and multicenter studies of adverse pregnancy outcome; (2) demonstrate our ability to enroll and provide maternal and newborn follow-up to subjects enrolled in MFMU trials; and (3) delineate our unique suitability in terms of technical and multidisciplinary content expertise to address the objectives of the MFMU Network. We are enthusiastic about continuing to contribute to the success of the MFMU Network and its continued pre-eminence in clinical research.

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