Combined analysis of mortality among nuclear workers
核工作人员死亡率综合分析
基本信息
- 批准号:8091704
- 负责人:
- 金额:$ 7.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-09-01 至 2013-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): In the 1960s, the US Atomic Energy Commission initiated a research program on the health and mortality of US nuclear workers. From the outset, it was noted that facility-specific cohort studies were unlikely to include sufficient numbers of workers to provide statistically precise epidemiological findings; however, combining data across facilities could allow an investigator to study associations in a large population of nuclear workers. We propose to conduct a pooled analysis of US worker data for employees of 5 major facilities selected based on cohort size, availability of demographic and employment history information, and completeness of radiation monitoring data: Oak Ridge National Laboratory, Savannah River Site, Hanford site, Idaho National Laboratory, and Portsmouth Naval Shipyard. An update of vital status follow-up of each cohort has been conducted recently, making the proposed analysis feasible. The proposed combined study of US workers will permit us to address outstanding questions regarding variation in radiation risks with time-since-exposure and age-at-exposure, as well as variation in radiation risks by type of cancer. We propose to employ state-of-the- art methods to minimize bias due to confounding, sensitivity analyses to assess the impact of exposure misclassification, and innovative regression models to assess effect measure modification and between-cohort heterogeneity in radiation risks. Moreover, a causal interpretation of epidemiological study findings is strengthened by evidence of reproducibility and consistency. Therefore, we propose to empirically assess the consistency of results derived from US nuclear worker data with results derived from UK and French nuclear worker cohorts, two nations that also developed large nuclear programs. A novel hierarchical regression approach will be used to assess the consistency of findings between US, UK, and French workers in a joint analysis that employs comparable analytical methods for each cohort. If pooling data from these 3 countries is appropriate, an international combined analysis will be conducted in order to derive the most precise radiation risk estimates for nuclear workers reported to-date. The proposed international combined analysis will have more than twice the statistical power of any prior epidemiological study of cancer among nuclear workers. The findings of this research project are expected to have substantial impact on discussions regarding occupational radiation risks and radiation protection.
PUBLIC HEALTH RELEVANCE: There has not been a report on a combined cohort analysis of associations between radiation exposure and all cancer mortality among US nuclear workers in over two decades. We propose to conduct a pooled analysis of recently-updated US nuclear worker data for Oak Ridge National Laboratory, Savannah River Site, Hanford site, Idaho National Laboratory, and Portsmouth Naval Shipyard. Updated data are available for each of these cohorts providing the basis for a major update of US combined nuclear worker cohort analyses. The study will address outstanding questions regarding latency effects, site specific cancer risks, and modification by age at exposure. In order to strengthen interpretation of these analyses, we propose to assess the consistency of findings derived from US nuclear worker data with those derived from UK and French nuclear worker cohorts and, if appropriate, to conduct an international pooled analysis of these data. This ambitious study draws upon large existing repositories of nuclear worker data. The findings of the proposed study are expected to have substantial impact on understanding of occupational radiation risks and the adequacy of current radiation protection standards.
描述(申请人提供):20世纪60年代,美国原子能委员会发起了一项关于美国核工人健康和死亡率的研究计划。从一开始,人们就注意到,特定于设施的队列研究不太可能包括足够数量的工人来提供统计上精确的流行病学调查结果;然而,合并跨设施的数据可以让研究人员研究大量核工人群体中的关联。我们建议对根据队列规模、人口统计和就业历史信息的可用性以及辐射监测数据的完整性选择的5个主要设施的员工的美国工人数据进行汇总分析:橡树岭国家实验室、萨凡纳河站点、汉福德站点、爱达荷州国家实验室和朴茨茅斯海军造船厂。最近对每个队列的生命状态随访进行了更新,使拟议的分析可行。对美国工人的拟议综合研究将使我们能够解决有关辐射风险随暴露时间和暴露年龄的变化以及癌症类型辐射风险变化的悬而未决的问题。我们建议采用最先进的方法,以尽量减少由于混淆,敏感性分析,以评估暴露错误分类的影响,和创新的回归模型,以评估效果的措施修改和队列间的异质性辐射风险的偏差。此外,流行病学研究结果的因果解释得到了可重复性和一致性证据的加强。因此,我们建议从经验上评估来自美国核工人数据的结果与来自英国和法国核工人队列的结果的一致性,这两个国家也开发了大型核计划。一种新的分层回归方法将用于评估美国,英国和法国工人在联合分析中发现的一致性,该分析采用了每个队列的可比分析方法。如果从这三个国家汇集数据是适当的,将进行国际综合分析,以得出迄今为止报告的核工作人员最准确的辐射风险估计。拟议中的国际综合分析将具有两倍以上的统计能力,任何以前的流行病学研究的癌症在核工作人员。该研究项目的结果预计将对有关职业辐射风险和辐射防护的讨论产生重大影响。
公共卫生相关性:二十多年来,还没有关于美国核工人辐射暴露与所有癌症死亡率之间关系的联合队列分析报告。我们建议对橡树岭国家实验室、萨凡纳河站点、汉福德站点、爱达荷州国家实验室和朴茨茅斯海军造船厂最近更新的美国核工作人员数据进行汇总分析。这些队列中的每一个都有更新的数据,为美国联合核工人队列分析的重大更新提供了基础。该研究将解决有关潜伏期效应、特定部位癌症风险和暴露年龄变化的突出问题。为了加强对这些分析的解释,我们建议评估来自美国核工人数据的结果与来自英国和法国核工人队列的结果的一致性,并在适当的情况下,对这些数据进行国际汇总分析。这项雄心勃勃的研究利用了现有的大型核工人数据库。这项研究的结果将对了解职业辐射风险和现行辐射防护标准的适当性产生重大影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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DAVID B RICHARDSON其他文献
DAVID B RICHARDSON的其他文献
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{{ truncateString('DAVID B RICHARDSON', 18)}}的其他基金
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