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Folding RNA: Influenza

Folding RNA: Influenza
折叠 RNA：流感
批准号：
8016941
负责人：
DOUGLAS H. TURNER
金额：
$6.2万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-01-01 至 2013-12-31
来源：
https://reporter.nih.gov/project-details/8016941
关键词：
AcademyAffectAlgorithmsBenchmarkingBindingBioinformaticsBiological ModelsBuffaloesChemicalsChemistryCodeCollaborationsCommunitiesDNADNA Insertion ElementsDatabasesDiseaseDoctor of MedicineFoundationsGenomeGenomicsGoalsGrantHeadInfluenzaInfluenza A Virus, H5N1 SubtypeInfluenza TherapeuticInstitutesKnowledgeLeadMapsMeasuresMethodsModelingNew YorkNucleotidesOligonucleotide MicroarraysOligonucleotidesPolandPolishesProteinsRNARNA BindingRNA DatabasesRNA FoldingRNA InterferenceResearchRetrotransposonScienceSmall Interfering RNAStructureTestingTherapeuticThermodynamicsUnited States National Institutes of HealthUniversitiesVietnamVirionVirusWorkbasecomputer programdesignexperiencefluimprovedinfluenzavirusinsightnovelparent grantprofessorresearch studyrestraintthree dimensional structure

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英文摘要
DESCRIPTION (provided by applicant): This research will be done at the University of Rochester and the Polish Academy of Sciences Institute of Bioorganic Chemistry in Poznan, Poland. The work will be in collaboration with Prof. Douglas H. Turner at the University of Rochester as an extension of NIH Grant No. RO1GM22939, 8-15-2008 to 7-31-2012, and will include additional collaborators at the University of Rochester (D.H. Mathews, S.D. Kennedy, and B. Kim) and at the State University of New York at Buffalo (M.D. Disney). The research will be done by Dr. Elzbieta Kierzek, who is the equivalent of an Assistant Professor at the Institute of Bioorganic Chemistry in Poznan. The goals of the work are to improve methods for predicting and determining the RNA secondary structures of influenza virus and to discover compounds that can lead to therapeutics for influenza RNA. PUBLIC HEALTH RELEVANCE: Viruses with RNA genomes are responsible for many diseases, including influenza. This project studies methods to determine rapidly the structures of influenza RNA and to discover compounds capable of therapeutically targeting the RNA.
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Folding RNA: Influenza
  • 批准号：
    8410080
  • 项目类别：
  • 资助金额：
    $5.26万
  • 财政年份：
    2011
  • 负责人：
    DOUGLAS H. TURNER
  • 依托单位：
    UNIVERSITY OF ROCHESTER
Folding RNA: Influenza
  • 批准号：
    8210912
  • 项目类别：
  • 资助金额：
    $5.54万
  • 财政年份：
    2011
  • 负责人：
    DOUGLAS H. TURNER
  • 依托单位：
    UNIVERSITY OF ROCHESTER
FOLDING RNA WITH MODIFIED OLIGONUCLEOTIDES
  • 批准号：
    2765582
  • 项目类别：
  • 资助金额：
    $3.65万
  • 财政年份：
    1999
  • 负责人：
    DOUGLAS H. TURNER
  • 依托单位：
    UNIVERSITY OF ROCHESTER
RNA TARGETING WITH TERTIARY INTERACTIONS
  • 批准号：
    2873820
  • 项目类别：
  • 资助金额：
    $7.93万
  • 财政年份：
    1999
  • 负责人：
    DOUGLAS H. TURNER
  • 依托单位：
    UNIVERSITY OF ROCHESTER
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