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Folding RNA: Influenza

折叠 RNA：流感

基本信息

批准号：
8410080
负责人：
DOUGLAS H. TURNER
金额：
$ 5.26万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-01-01 至 2015-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8410080
关键词：
Academy Affect Algorithms Benchmarking Binding Bioinformatics Biological Models Buffaloes Chemicals Chemistry Code Collaborations Communities DNA DNA Insertion Elements Databases Disease Doctor of Medicine Foundations Genome Genomics Goals Grant Head Influenza Influenza A Virus, H5N1 Subtype Influenza Therapeutic Institutes Knowledge Lead Maps Measures Methods Modeling New York Nucleotides Oligonucleotide Microarrays Oligonucleotides Poland Polishes Proteins RNA RNA Binding RNA Databases RNA Folding RNA Interference Research Retrotransposon Science Small Interfering RNA Structure Testing Therapeutic Thermodynamics United States National Institutes of Health Universities Vietnam Virion Virus Work base computer program design experience flu improved influenzavirus insight novel parent grant professor public health relevance research study restraint three dimensional structure

项目摘要

DESCRIPTION (provided by applicant): This research will be done at the University of Rochester and the Polish Academy of Sciences Institute of Bioorganic Chemistry in Poznan, Poland. The work will be in collaboration with Prof. Douglas H. Turner at the University of Rochester as an extension of NIH Grant No. RO1GM22939, 8-15-2008 to 7-31-2012, and will include additional collaborators at the University of Rochester (D.H. Mathews, S.D. Kennedy, and B. Kim) and at the State University of New York at Buffalo (M.D. Disney). The research will be done by Dr. Elzbieta Kierzek, who is the equivalent of an Assistant Professor at the Institute of Bioorganic Chemistry in Poznan. The goals of the work are to improve methods for predicting and determining the RNA secondary structures of influenza virus and to discover compounds that can lead to therapeutics for influenza RNA.

描述（由申请人提供）：本研究将在罗切斯特大学和位于波兰波兹南的波兰科学院生物有机化学研究所进行。这项工作将与道格拉斯H.特纳在罗切斯特大学作为美国国立卫生研究院批准号RO 1GM 22939，8-15-2008至7-31-2012的扩展，并将包括在罗切斯特大学（D.H.马修斯肯尼迪和B。金博士）和布法罗的纽约州立大学（医学博士）。迪士尼）。这项研究将由Elzbieta Kierzek博士完成，他相当于波兹南生物有机化学研究所的助理教授。这项工作的目标是改进预测和确定流感病毒RNA二级结构的方法，并发现可以导致流感RNA治疗的化合物。

项目成果

期刊论文数量（13）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Recognition of RNA duplexes by chemically modified triplex-forming oligonucleotides.

DOI：
10.1093/nar/gkt352
发表时间：
2013-07
期刊：
Nucleic acids research
影响因子：
14.9
作者：
Zhou Y;Kierzek E;Loo ZP;Antonio M;Yau YH;Chuah YW;Geifman-Shochat S;Kierzek R;Chen G
通讯作者：
Chen G

A Conserved Secondary Structural Element in the Coding Region of the Influenza A Virus Nucleoprotein (NP) mRNA Is Important for the Regulation of Viral Proliferation.