RCMI Multidisciplinary And Translational Research Infrastructure EXpansion Hawaii

描述（由申请人提供）：作为在太平洋盆地从事生物医学和生物行为研究的主要美国高等教育机构，夏威夷大学 (UH) 通过 PAR-09-261 寻求国家研究资源中心 (NCRR) 少数族裔机构基础设施研究中心 (RCMI) 临床和转化研究 (RCTR) 奖项的支持。通过 RCTR 奖项，我们建议在夏威夷建立 RCMI 多学科和转化研究基础设施扩建项目（RMATRIX Hawaii 或 RMATRIX），作为夏威夷州临床和转化科学的综合“家”。我们与 RCMI 转化研究网络 (RTRN)、查尔斯德鲁医学与科学大学以及机构、社区和私人合作伙伴合作，寻求重组和扩展夏威夷大学现有的 RCMI 临床和转化研究基础设施。 拟议的 RMATRIX 关键功能经过精心设计，旨在提供临床和转化研究基础设施，以扩大健康计划，解决全州的健康差距。通过关键职能和健康调查团队，RMATRIX 将提供必要的工具和协作，以支持全州的基础、临床和转化研究人员。鉴于夏威夷大学及其社区合作者在每个健康计划中都拥有相当丰富的基础和“从实验室到临床”的转化研究经验，因此还将在这六个主题领域寻求与临床转化科学奖 (CTSA) 相关机构的 RTRN 转化研究人员和研究人员的合作。 我们将通过建立和协调包括以下功能的基础设施来实现在夏威夷创建临床和转化研究综合家园的广泛目标：1）总体方法和治理； 2) 合作与伙伴关系； 3）多学科研究教育、培训和职业发展； 4）生物医学信息学与生物统计学； 5) 参与者和临床资源； 6) 道德和监管支持； 7）评估。 公共卫生相关性（由申请人提供）：RMATRIX 力求实现其总体目标，即为临床和转化研究创建一个综合学术中心，旨在改善夏威夷不同人群的健康结果。通过整合和协调关键职能来促进研究进程，RMATRIX 将有助于减少和消除整个 RCMI 社区的健康差距。

DESCRIPTION (provided by applicant): As the principal U.S. institution of higher education engaged in biomedical and biobehavioral research within the Pacific basin, the University of Hawaii (UH) seeks support from the National Center for Research Resources (NCRR) for a Research Centers in Minority Institutions Infrastructure (RCMI) for Clinical and Translational Research (RCTR) award through PAR-09-261. Through the RCTR award, we propose to establish the RCMI Multidisciplinary and Translational Research Infrastructure Expansion in Hawaii (RMATRIX Hawaii or RMATRIX) as the integrated "home" for clinical and translational science in the State of Hawaii. In collaboration with the RCMI Translational Research Network (RTRN), Charles Drew University of Medicine and Science, and with institutional, community-based, and private partners, we seek to reorganize and expand the existing RCMI clinical and translational research infrastructure at UH. The proposed RMATRIX Key Functions have been carefully designed to provide the clinical and translational research infrastructure to expand the HEALTH Initiatives to address health disparities throughout the state. Through the Key Functions and HEALTH investigative teams, RMATRIX will provide essential tools and collaboration to support basic, clinical and translational researchers throughout the state. Given that UH and its Community Collaborators have considerable basic and "bench to bedside" translational research experience in each of the HEALTH Initiatives, collaboration with RTRN translational researchers and investigators at Clinical Translational Science Award (CTSA) associated institutions will also be sought in these six thematic areas. We will accomplish our broad objective of creating an integrated home for clinical and translational research in Hawaii through the establishment and coordination of infrastructure that comprises functions which include: 1) Overall Approach and Governance; 2) Collaborations and Partnerships; 3) Multidisciplinary Research Education, Training and Career Development; 4) Biomedical Informatics and Biostatistics; 5) Participant and Clinical Resources; 6) Ethics and Regulatory Support; 7) Evaluation. PUBLIC HEALTH RELEVANCE (provided by applicant): RMATRIX seeks to fulfill its overall objective of creating an integrated academic home for clinical and translational research designed to improve health outcomes in Hawaii's diverse populations. By facilitating the research process through consolidation and coordination of Key Functions, RMATRIX will contribute to the reduction and elimination of health disparities across the RCMI community.