NIDDK Multidisciplinary Predoctoral Training in Discovery and Translational Research

NIDDK 发现和转化研究多学科博士前培训

• 批准号: 10612790
• 负责人: DANIEL D BILLADEAU
• 金额: $ 20.43万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10612790
• 关键词: National Institute of Diabetes and Digestive and Kidney Diseases; Training; Translational Research; multidisciplinary; pre-doctoral

PROJECT SUMMARY/ABSTRACT This is a new application for multidisciplinary predoctoral training in discovery and translational research at Mayo Clinic in the inter-related fields of Diabetes and Metabolic Disease, Digestive Diseases and Gastroenter- ology, and Kidney Disease and Hypertension (DDK). The overarching objective is to develop a diverse pool of well-trained biomedical career scientists with the experience and skillsets to become leaders in the next gener- ation of DDK researchers. Two senior and accomplished Mayo scientists with an extensive background in graduate education and mentoring will co-direct this program centered upon four Mechanism-Centric Research Communities in i) Bioengineering and Biophysical Analysis, ii) Cell-to-Cell Communication, iii) Genomic Regu- lation, and iv) Intracellular Signaling, with 24 interdisciplinary faculty members and over $20 million in funding. This core DDK faculty provides a robust infrastructure with a successful history of training career scientists in discovery-based and translational biomedical research. These laboratories offer a rich mentoring and training environment that is uniquely tailored to the individual student while also promoting collective experiences across multiple disciplines. The program's Specific Aims focus on fundamental aspects of reproducible and rigorous biomedical research that align with NIH/NIDDK priorities. These are to: i) Offer a solid foundation in scientific reasoning, research design, rigor, quantitative experimental approaches and analysis of datasets, with objective interpretation of results; ii) Foster broad multidisciplinary understanding combined with critical independent thinking skills, while implementing the ability to identify outstanding biomedical questions and ini- tiate new approaches to advance the field; iii) Develop effective oral and written communication skills across diverse audiences; iv) Promote ethical conduct in biomedical research and team skills that facilitate collabora- tive scientific research alongside colleagues while promoting an inclusive work environment; v) Provide the background to identify and effectively transition into productive basic and clinical DDK investigators. The pro- gram strongly supports synergistic interactions between Mayo Clinic Basic Science Departments and NIDDK- funded Centers in Digestive Disease, Translational PKD, and Pathobiology of the Enteric System. The stu- dents will actively engage in a full array of programmatic activities, including journal clubs, seminar and works- in-progress series, career and professional development events, annual retreat, Mayo Graduate School wide symposium and poster session, along with participation in national meetings and others. These activities syn- ergize with three related DDK postdoctoral programs at Mayo Clinic in Diabetes and Metabolism, Digestive Diseases, and Kidney Disease, while offering a complete continuum from summer undergraduate research experiences through PhD and postdoctoral training. Requirements for completion of the PhD degree conform to Mayo Graduate School requirements, including a first author publication. The program draws from a strong pool of 75+ qualified Mayo Clinic graduate students; we request support for six predoctoral trainees per year.

项目总结/摘要 这是一个新的应用程序，在发现和转化研究的多学科博士前培训， 马约诊所在糖尿病和代谢疾病，消化系统疾病和胃肠相关领域- 肾脏疾病和高血压（DDK）。总体目标是建立一个多样化的人才库， 训练有素的生物医学职业科学家，拥有成为下一代领导者的经验和技能， DDK的研究人员。两位资深的、有成就的马约科学家， 研究生教育和指导将共同指导这一计划集中在四个机制为中心的研究 社区在i）生物工程和生物物理分析，ii）细胞间通讯，iii）基因组调控， lation，和iv）细胞内信号传导，有24个跨学科的教师和超过2000万美元的资金。 这一核心DDK教师提供了一个强大的基础设施，具有成功的职业科学家培训历史， 基于发现和转化的生物医学研究。这些实验室提供丰富的指导和培训 一个独特的环境，为个别学生量身定制，同时也促进集体经验 跨多个学科。该计划的具体目标侧重于可重复性和 严格的生物医学研究，符合NIH/NIDDK的优先事项。（一）奠定坚实的基础， 科学推理，研究设计，严谨性，定量实验方法和数据集分析， （二）促进广泛的多学科理解， 独立思考能力，同时实施能力，以确定突出的生物医学问题和信息， 证明新的方法，以推动该领域; iii）发展有效的口头和书面沟通技巧， ㈣促进生物医学研究中的道德行为和促进合作的团队技能， 与同事一起进行积极的科学研究，同时促进包容性的工作环境; v）提供 背景，以确定和有效地过渡到生产基础和临床DDK研究者。亲- gram强烈支持马约诊所基础科学部门和NIDDK之间的协同互动， 在消化系统疾病，翻译PKD和肠道系统的病理生物学中心资助。学生- 牙医将积极参与一系列的方案活动，包括期刊俱乐部，研讨会和作品- 正在进行的系列，职业和专业发展活动，年度务虚会，马约研究生院范围内 专题讨论会和海报展示会，沿着参加国家会议和其他会议。这些活动的合成- 在马约诊所的三个相关的DDK博士后项目中， 疾病，肾脏疾病，同时提供了一个完整的连续性，从夏季本科研究 通过博士和博士后培训获得经验。完成博士学位的要求符合 到马约研究生院的要求，包括第一作者出版物。该计划从一个强大的 超过75名合格的马约诊所研究生;我们要求每年支持6名博士前培训生。