VITAMIN D SUPPLEMENTATION AND MUSCLE FUNCTION -CRU PILOT STUDY

维生素 D 补充剂和肌肉功能 -CRU 试点研究

• 批准号: 8167060
• 负责人: STEPHEN B. KRITCHEVSKY
• 金额: $ 0.17万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167060
• 关键词: Address; Binding; Clinic; Computer Retrieval of Information on Scientific Projects Database; Data; Equilibrium; Funding; Future; Goals; Grant; Home environment; Individual; Institution; Measures; Muscle; Muscle function; Performance; Persons; Physical Function; Pilot Projects; Recruitment Activity; Regimen; Research; Research Design; Research Personnel; Resources; Sample Size; Serum; Source; Supplementation; United States National Institutes of Health; Vitamin D; Vitamins; cost effective; design; falls; functional decline; high risk; improved; muscle strength; randomized trial; remediation; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. whether remediation of vitamin D insufficiency will improve physical function and the potential mechanisms involved are unclear. Previous vitamin D supplementation trials, primarily in falls clinic or home-bound individuals, have produced mixed results on muscle strength and physical performance; however, most trials did not specifically recruit individuals who were vitamin D insufficient nor is the potential mechanism of action understood well enough to appropriately select those individuals most likely to benefit. In order to determine if vitamin D supplementation will improve physical function, a trial is needed among vitamin D insufficient individuals in whom vitamin D supplementation is most likely to be beneficial. The primary goal of this feasibility pilot study is to collect key information to help design a randomized trial to determine whether vitamin D supplementation will delay declines in physical function. The pilot study will help us determine cost-effective strategies for identifying persons at high risk for functional decline with insufficient vitamin D levels, determine the serum vitamin D response to a regimen designed to attain sufficient vitamin D levels, and provide preliminary data of key functional measures (balance, short physical performance battery (SPPB) and muscle power) for the future larger study design. The secondary goal is to begin to examine potential mechanisms by which vitamin D supplementation may enhance physical performance and muscle contractility. Before a definitive trial is designed to answer these questions, we must first address important questions regarding feasibility, sample size, and preliminary evidence of effects.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 维生素D不足的补救是否会改善身体功能以及涉及的潜在机制尚不清楚。以前的维生素D补充试验，主要是在福尔斯诊所或家庭的个人，产生了混合的结果对肌肉力量和身体表现;然而，大多数试验并没有专门招募个人谁是维生素D不足，也不是潜在的作用机制理解不够好，适当地选择那些人最有可能受益。为了确定维生素D补充剂是否会改善身体功能，需要在维生素D不足的个体中进行试验，其中维生素D补充剂最有可能有益。 这项可行性试点研究的主要目标是收集关键信息，以帮助设计一项随机试验，以确定维生素D补充剂是否会延缓身体功能的下降。该试点研究将帮助我们确定具有成本效益的策略，用于识别维生素D水平不足的功能下降高风险人群，确定血清维生素D对旨在获得足够维生素D水平的方案的反应，并为未来更大规模的研究设计提供关键功能指标（平衡，短体能电池（SPPB）和肌肉力量）的初步数据。第二个目标是开始检查补充维生素D可能增强身体表现和肌肉收缩力的潜在机制。在设计一个明确的试验来回答这些问题之前，我们必须首先解决有关可行性、样本量和效应的初步证据等重要问题。