PROTEOMICS AND GENOMICS CORE FACILITY

蛋白质组学和基因组学核心设施

• 批准号: 8166232
• 负责人: ROBERT G HOLT
• 金额: $ 33.75万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-08 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166232
• 关键词: Acquired Immunodeficiency Syndrome; Area; Bioinformatics; Biological; Biomedical Research; Communities; Computer Retrieval of Information on Scientific Projects Database; Computer software; Core Facility; DNA Microarray Chip; DNA Sequence; Data; Data Analyses; Databases; Electronics; Equipment; Equipment and supply inventories; Experimental Designs; Faculty; Funding; Gene Proteins; Genomics; Goals; Grant; HIV; Health Services Research; Housing; Human Resources; Institution; Journals; Literature; Mission; Molecular; Productivity; Proteomics; Publications; Reagent; Research; Research Personnel; Research Support; Resources; Services; Source; Speed; Students; Technical Expertise; Time; Training; Training Programs; United States National Institutes of Health; Women' s Health; base; computing resources; cost; data sharing; graduate student; innovation; medical schools; programs; protein expression; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. NOTE: Tables and Figures were uploaded with Program Summary. A. Specific Aims The mission of the Genomics and Proteomics Core is to provide the technical support and services for research faculty, graduate students and research support staff to perform innovative research on genes and proteins with special emphasis on the support of research in the areas of women health, AIDS, HIV, and related fields. The Core is multi-functional since this Core provides the equipment and technical expertise to perform experiments on gene and protein expression, the computational resources for data analysis and data sharing (i.e., bioinformatics) and access to the existing literature and databases to facilitate experimental design. The specific functions of the Genomics and Proteomics Core at Meharry are: 1) to provide to the research faculty, graduate students and research support staff of Meharry Medical College the necessary expert personnel and equipment to provide the services of automated DNA sequencing, DNA Microarray, and real-time PCR; 2) to stock an inventory of reagents for research and facilitate the purchase of molecular biological reagents for researchers; 3) to provide technical assistance and training in the use of shared equipment housed in the facility; 4) to increase the access to electronic information sources including electronic journals and remote databases using the capacity and speed of Internet2; 5) to provide the technical expertise, hardware and software for the analysis of genomic and proteomic data; and 6) to provide a program of training in genomics and proteomics for faculty, staff and graduate students. The ultimate goal of the Genomics and Proteomics Core is to provide services needed by the research community at Meharry to increase research productivity as evidenced by increased grants submission and acquisition and increased publication numbers by faculty. In summary, the primary purpose of the Genomics and Proteomics Core is to provide on a continuing basis services to enhance the capability of the researchers at Meharry Medical College to perform significant biomedical research. The major service activities of the Genomics and Proteomics Core are to provide accurate DNA sequence information rapidly and cost-effectively, provide technical assistance with the use of shared equipment housed in the Core and provide convenient access to molecular biological reagents. The specific goals for this component are: 1. To provide to the faculty, students and staff of Meharry Medical College the necessary expert personnel and equipment to provide the services of automated DNA sequencing, DNA microarray, and real-time PCR. 2. To provide technical assistance with the use of shared equipment housed in the Genomics and Proteomics Core. 3. To increase the access to electronic information sources including e-journals and remote databases. 4. To provide the technical expertise, hardware and software for the experimental design and analysis of genomic and proteomic data. 5. To provide a program of training in genomics and proteomics for faculty, staff and students.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 注：表和图与程序摘要一起上传。 A. 具体目标 基因组学和蛋白质组学核心的使命是为研究人员、研究生和研究支持人员提供技术支持和服务，以进行基因和蛋白质的创新研究，特别强调支持妇女健康、艾滋病、艾滋病毒和相关领域的研究。 该核心是多功能的，因为该核心提供了设备和技术专长来进行基因和蛋白质表达实验，用于数据分析和数据共享的计算资源（即，生物信息学）和访问现有文献和数据库以促进实验设计。Meharry基因组学和蛋白质组学核心的具体功能是：1）为Meharry医学院的研究人员，研究生和研究支持人员提供必要的专家人员和设备， 提供自动化DNA测序、DNA微阵列和实时聚合酶链反应服务; 2）储存研究试剂库存，并为研究人员购买分子生物试剂提供便利; 3）提供技术援助和培训，以使用设施内的共用设备;（4）利用因特网的容量和速度，增加对电子信息源的访问，包括电子期刊和远程数据库; 5）提供基因组和蛋白质组分析的技术专长、硬件和软件 数据;和6）为教职员工和研究生提供基因组学和蛋白质组学培训计划。 基因组学和蛋白质组学核心的最终目标是提供所需的研究社区在Meharry的服务，以提高研究生产力的增加赠款提交和收购和教师增加出版物数量证明。 总而言之，基因组学和蛋白质组学核心的主要目的是提供持续的服务，以提高梅哈里医学院研究人员进行重大生物医学研究的能力。基因组学和蛋白质组学核心的主要服务活动是迅速和具有成本效益地提供准确的DNA序列信息，使用核心中的共享设备提供技术援助，并提供方便的分子生物试剂。这一部分的具体目标是： 1.为Meharry医学院的教师，学生和工作人员提供必要的专家人员和设备，以提供自动DNA测序，DNA微阵列和实时PCR服务。 2.为使用基因组学和蛋白质组学核心中的共享设备提供技术援助。 3.增加对电子信息来源的访问，包括电子期刊和远程数据库。 4.为基因组和蛋白质组数据的实验设计和分析提供技术专长、硬件和软件。 5.为教职员工和学生提供基因组学和蛋白质组学的培训计划。