PROTEOMICS AND GENOMICS CORE FACILITY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 注：表格和数字与计划摘要一起上传。 A.具体目标 基因组学和蛋白质组学核心的使命是为研究人员、研究生和研究支持人员提供技术支持和服务，以进行基因和蛋白质的创新研究，特别是支持妇女健康、艾滋病、艾滋病毒和相关领域的研究。 核心是多功能的，因为该核心提供了进行基因和蛋白质表达实验的设备和技术专长，提供了用于数据分析和数据共享(即生物信息学)的计算资源，以及访问现有文献和数据库以促进实验设计。Meharry基因组和蛋白质组核心的具体职能是：1)为Meharry医学院的研究人员、研究生和研究支持人员提供必要的专家人员和设备，以 提供自动DNA测序、DNA微阵列和实时聚合酶链式反应服务；2)储存用于研究的试剂库存，并为研究人员购买分子生物试剂提供便利；3)在使用设施内的共享设备方面提供技术援助和培训；4)利用互联网的能力和速度增加电子信息源的获取，包括电子期刊和远程数据库；5)为基因组和蛋白质组分析提供技术专门知识、硬件和软件 数据；以及6)为教职员工和研究生提供基因组学和蛋白质组学方面的培训。 基因组学和蛋白质组学核心的最终目标是提供Meharry研究社区所需的服务，以提高研究生产率，这体现在拨款提交和获得的增加以及教师发表论文数量的增加。 总而言之，基因组学和蛋白质组学核心的主要目的是持续提供服务，以提高梅哈里医学院研究人员进行重大生物医学研究的能力。基因组学和蛋白质组学核心的主要服务活动是快速和具有成本效益地提供准确的DNA序列信息，通过使用核心内的共享设备提供技术援助，并提供方便的分子生物试剂。该组件的具体目标是： 1.为梅哈里医学院的教职员工提供必要的专家人员和设备，以提供自动DNA测序、DNA微阵列和实时聚合酶链式反应服务。 2.在使用基因组学和蛋白质组学核心内的共用设备方面提供技术援助。 3.增加对电子期刊和远程数据库等电子信息来源的获取。 4.为基因组和蛋白质组数据的实验设计和分析提供技术专长、硬件和软件。 5.为教职员工和学生提供基因组学和蛋白质组学方面的培训。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. NOTE: Tables and Figures were uploaded with Program Summary. A. Specific Aims The mission of the Genomics and Proteomics Core is to provide the technical support and services for research faculty, graduate students and research support staff to perform innovative research on genes and proteins with special emphasis on the support of research in the areas of women health, AIDS, HIV, and related fields. The Core is multi-functional since this Core provides the equipment and technical expertise to perform experiments on gene and protein expression, the computational resources for data analysis and data sharing (i.e., bioinformatics) and access to the existing literature and databases to facilitate experimental design. The specific functions of the Genomics and Proteomics Core at Meharry are: 1) to provide to the research faculty, graduate students and research support staff of Meharry Medical College the necessary expert personnel and equipment to provide the services of automated DNA sequencing, DNA Microarray, and real-time PCR; 2) to stock an inventory of reagents for research and facilitate the purchase of molecular biological reagents for researchers; 3) to provide technical assistance and training in the use of shared equipment housed in the facility; 4) to increase the access to electronic information sources including electronic journals and remote databases using the capacity and speed of Internet2; 5) to provide the technical expertise, hardware and software for the analysis of genomic and proteomic data; and 6) to provide a program of training in genomics and proteomics for faculty, staff and graduate students. The ultimate goal of the Genomics and Proteomics Core is to provide services needed by the research community at Meharry to increase research productivity as evidenced by increased grants submission and acquisition and increased publication numbers by faculty. In summary, the primary purpose of the Genomics and Proteomics Core is to provide on a continuing basis services to enhance the capability of the researchers at Meharry Medical College to perform significant biomedical research. The major service activities of the Genomics and Proteomics Core are to provide accurate DNA sequence information rapidly and cost-effectively, provide technical assistance with the use of shared equipment housed in the Core and provide convenient access to molecular biological reagents. The specific goals for this component are: 1. To provide to the faculty, students and staff of Meharry Medical College the necessary expert personnel and equipment to provide the services of automated DNA sequencing, DNA microarray, and real-time PCR. 2. To provide technical assistance with the use of shared equipment housed in the Genomics and Proteomics Core. 3. To increase the access to electronic information sources including e-journals and remote databases. 4. To provide the technical expertise, hardware and software for the experimental design and analysis of genomic and proteomic data. 5. To provide a program of training in genomics and proteomics for faculty, staff and students.