PROTEOMICS AND GENOMICS CORE FACILITY

蛋白质组学和基因组学核心设施

• 批准号: 7561521
• 负责人: ROBERT G HOLT
• 金额: $ 41.56万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7561521
• 关键词: Behavioral; Biological; Biomedical Research; Communities; Computer Retrieval of Information on Scientific Projects Database; Computer software; Core Facility; DNA Microarray Chip; DNA Microarray format; DNA Sequence; Data; Data Analyses; Databases; Electronics; Equipment; Equipment and supply inventories; Experimental Designs; Faculty; Funding; Gene Proteins; Genomics; Goals; Grant; Health; Housing; Human Resources; Institution; Journals; Laboratories; Literature; Location; Medical; Molecular; Molecular Biology; Molecular Genetics; Molecular Neurobiology; Neurosciences; Polymerase Chain Reaction; Proteomics; Purpose; Reagent; Research; Research Personnel; Resources; School Dentistry; Services; Sickle Cell; Source; Speed; Structure; Students; Technical Expertise; Time; Training Programs; United States National Institutes of Health; abstracting; base; college; cost; genetic analysis; protein expression; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. NOTE: Tables and Figures were uploaded with the Overall Research Summary file. ABSTRACT A. Specific AimsGenomics and Proteomics Core is a multifunctional facility with the objective of effectively providing the technical services and support required for research on genes and proteins. The Core is comprehensive since this Core provides the equipment and technical expertise to perform experiments on gene and protein expression, the computational resources for data analysis and data sharing and access to the existing literature and databases to facilitate experimental design. The specific functions of the Genomics and Proteomics Core at Meharry are: 1) to provide to the faculty, students and staff of Meharry Medical College the necessary expert personnel and equipment to provide the services of automated DNA sequencing, DNA microarray, and real-time PCR; 2) to stock an inventory of reagents for research and facilitate the purchase of molecular biological reagents for researchers; 3) to provide technical assistance with the use of shared equipment housed in the main and satellite laboratories; 4) to increase the access to electronic information sources including electronic journals and remote databases using the capacity and speed of Internet2; 5) to provide the technical expertise, hardware and software for the analysis of genetic, molecular and DNA microarray data; and 6) to provide a program of training in genomics and proteomics for faculty, staff and students. The ultimate goal of the Genomics and Proteomics Core is to provide services needed by the research community at Meharry to increase research productivity.The primary purpose of the Genomics and Proteomics Core is to provide on a continuing basis services to enhance the capability of the researchers at Meharry Medical College to perform cutting edge biomedical research. The major service activities of the Genomics and Proteomics Core are to provide accurate DNA sequence information rapidly and cost-effectively, provide technical assistance with the use of shared equipment housed in the Core and provide convenient access to molecular biological reagents. The specific aims for this component are: 1) To relocate the existing Molecular Neurobiology Core Facility into renovated space and to consolidate its management and services with those of the Molecular Biology Core Facility within the structure of the new Genomics and Proteomics Core facility. In its new location, the core will support faculty in the Center for Womens Health Research, the Sickle Cell Center, the School of Dentistry, and the Center for Molecular and Behavioral Neuroscience. 2) To provide to the faculty, students and staff of Meharry Medical College the necessary expert personnel and equipment to provide the services of automated DNA sequencing, microarray, and real-time PCR. 3) To provide technical assistance with the use of shared equipment housed in the main and satellite laboratories of the Genomics and Proteomics Core. 4) To increase the access to electronic information sources including e-journals and remote databases using the capacity and speed of Internet2. 5) To provide the technical expertise, hardware and software for the analysis of genetic, molecular and microarray data. 6) To provide a program of training in genomics and proteomics for faculty, staff and students.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 注：表格和数字与整个研究总结文件一起上传。 摘要 答：特定目的基因组学和蛋白质组学核心是一个多功能设施，旨在有效地提供基因和蛋白质研究所需的技术服务和支持。核心是综合性的，因为这个核心提供了进行基因和蛋白质表达实验的设备和技术专长，提供了用于数据分析和数据共享的计算资源，以及访问现有文献和数据库以促进实验设计。Meharry基因组和蛋白质组学核心的具体职能是：1)向Meharry医学院的教职员工、学生和教职员工提供必要的专家人员和设备，以提供自动DNA测序、DNA微阵列和实时聚合酶链式反应服务；2)储存用于研究的试剂库存，并为研究人员购买分子生物试剂提供便利；3)利用主实验室和卫星实验室中的共享设备提供技术援助；4)利用Internet2的能力和速度增加对包括电子期刊和远程数据库在内的电子信息来源的访问；5)为基因、分子和DNA微阵列数据的分析提供技术专长、硬件和软件；以及6)为教职员工和学生提供基因组学和蛋白质组学方面的培训计划。基因组学和蛋白质组学核心的最终目标是为Meharry的研究社区提供所需的服务，以提高研究生产率。基因组和蛋白质组学核心的主要目的是持续提供服务，以增强Meharry医学院研究人员进行尖端生物医学研究的能力。基因组学和蛋白质组学核心的主要服务活动是快速和具有成本效益地提供准确的DNA序列信息，通过使用核心内的共享设备提供技术援助，并提供方便的分子生物试剂。这一组成部分的具体目标是：1)将现有的分子神经生物学核心设施搬迁到翻新的空间，并在新的基因组和蛋白质组学核心设施的结构内，将其与分子生物学核心设施的管理和服务合并。在新的地点，核心将支持妇女健康研究中心、镰刀细胞中心、牙科学院以及分子和行为神经科学中心的教职员工。2)为梅哈里医学院的教职员工提供必要的专家人员和设备，以提供自动DNA测序、微阵列和实时聚合酶链式反应服务。3)在使用基因组学和蛋白质组学核心的主实验室和卫星实验室的共用设备方面提供技术援助。4)利用Internet2的能力和速度，增加获取电子期刊和远程数据库等电子信息来源的机会。5)为遗传、分子和微阵列数据的分析提供技术专长、硬件和软件。6)为教职员工和学生提供基因组学和蛋白质组学方面的培训。