Evaluating a Brief Intensive Intervention for Children with Fragile X Syndrome
评估针对脆性 X 综合征儿童的短期强化干预措施
基本信息
- 批准号:7885475
- 负责人:
- 金额:$ 17.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-09-18 至 2013-06-30
- 项目状态:已结题
- 来源:
- 关键词:AdolescentAgeAreaArtsAwardBehaviorBehavior TherapyBehavioralBrainBrain regionChildClinicalCognitionCognitiveCognitive ScienceControl GroupsDevelopmental DisabilitiesDiagnosisDiseaseEnvironmentFragile X SyndromeFunctional Magnetic Resonance ImagingFunctional disorderGenderGeneticGoalsHippocampus (Brain)Image AnalysisIndividualInterventionInvestigationLearningMemoryMentorsMethodologyMethodsMetricNeurodevelopmental DisorderNeurosciencesOutcomeParietal LobePerformancePrefrontal CortexResearchResearch PersonnelResearch Project GrantsScientistSerial LearningSocioeconomic StatusStatistical ModelsStimulusStructureSyndromeTechniquesTrainingTranslatingTreatment Efficacyage groupagedbehavior changebehavior measurementcareer developmentcognitive changeeffective interventionexecutive functionimprovedintervention programneurogeneticsneuroimagingprogramsrelating to nervous systemresponseskill acquisitionskillsskills training
项目摘要
DESCRIPTION (provided by applicant): The long-term objective of this Mentored Clinical Scientist Research Career Development (K08) Award is to develop the candidate's skills in combining multi-modal neuroimaging with behavior analytic research so that he may become one of the first independent scientists to integrate applied behavioral analysis with clinical neuroscience investigation in the study of children with serious neurodevelopmental disorders. The candidate's specific research goal is to apply neuroimaging techniques to evaluate specific targeted behavior analytic interventions for children with fragile X syndrome. To accomplish this goal, the candidate will be mentored by experts in the fields of behavioral neurogenetics and neuroimaging and will pursue an educational program that includes advanced seminars in neuroimaging as well as formal coursework in the areas of cognitive psychology', genetics and neuroscience. The primary goal of the proposed research project is to target specific cognitive and behavioral weaknesses shown by individuals with fragile X syndrome (math and money skills) for intensive behavioral intervention. The efficacy of this intervention will be evaluated using specific neuroimaging metrics as well as behavioral measures. By understanding the neural correlates of behavior change, these neuroimaging metrics will be employed in statistical models to improve prediction of response outcome. Two subject groups will be exposed to the interventions: a group of children with fragile X syndrome (FXS), and a group of age- gender and IQ-matched subjects with a non-specific form of developmental disability (NSDD). Both groups will receive the neuroimaging prior to and following the intensive intervention conducted at Stanford over three days. It is hypothesized that effective intervention (as demonstrated by significant behavioral or cognitive change) will be associated with profiles of brain activation reflecting "normalization" of functional connectivity and/or compensatory activation. The candidate will also investigate whether particular profiles of activation at baseline predict response. Only limited information is available concerning optimal methods for enhancing cognitive abilities in individuals with FXS. If this intervention is found to be an effective method for learning in individuals with FXS, the technique could be rapidly translated into the clinical and educational environments, thus benefiting many children and adolescents with this disorder.
该指导临床科学家研究职业发展(K 08)奖的长期目标是发展候选人将多模态神经成像与行为分析研究相结合的技能,以便他可能成为第一批将应用行为分析与临床神经科学调查相结合的独立科学家之一,用于严重神经发育障碍儿童的研究。候选人的具体研究目标是应用神经影像学技术来评估脆性X综合征儿童的特定目标行为分析干预措施。为了实现这一目标,候选人将由行为神经遗传学和神经影像学领域的专家指导,并将参加一项教育计划,其中包括神经影像学高级研讨会以及认知心理学,遗传学和神经科学领域的正式课程。拟议研究项目的主要目标是针对脆性X综合征(数学和金钱技能)患者表现出的特定认知和行为弱点进行强化行为干预。将使用特定的神经影像学指标以及行为测量来评估这种干预的有效性。通过了解行为变化的神经相关性,这些神经成像指标将用于统计模型,以改善对反应结果的预测。两个受试者组将暴露于干预措施:一组患有脆性X综合征(FXS)的儿童,以及一组年龄-性别和智商匹配的非特异性发育障碍(NSDD)受试者。在斯坦福大学进行为期三天的强化干预之前和之后,两组都将接受神经成像。据推测,有效的干预(表现为显着的行为或认知变化)将与反映功能连接和/或代偿性激活的“正常化”的大脑激活的配置文件。候选人还将调查基线时的特定激活特征是否预测反应。关于增强FXS患者认知能力的最佳方法,只有有限的信息可用。如果发现这种干预是FXS患者学习的有效方法,该技术可以迅速转化为临床和教育环境,从而使许多患有这种疾病的儿童和青少年受益。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Scott S Hall其他文献
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{{ truncateString('Scott S Hall', 18)}}的其他基金
Effects of Social Gaze Training on Brain and Behavior in Fragile X Syndrome
社交凝视训练对脆性 X 综合征患者大脑和行为的影响
- 批准号:
9212826 - 财政年份:2015
- 资助金额:
$ 17.3万 - 项目类别:
Understanding severe disruptive behaviors in adolescents with fragile X syndrome
了解患有脆性 X 综合征的青少年的严重破坏性行为
- 批准号:
8629775 - 财政年份:2013
- 资助金额:
$ 17.3万 - 项目类别:
Understanding severe disruptive behaviors in adolescents with fragile X syndrome
了解患有脆性 X 综合征的青少年的严重破坏性行为
- 批准号:
8512266 - 财政年份:2013
- 资助金额:
$ 17.3万 - 项目类别:
Evaluating a Brief Intensive Intervention for Children with Fragile X Syndrome
评估针对脆性 X 综合征儿童的短期强化干预措施
- 批准号:
8105091 - 财政年份:2008
- 资助金额:
$ 17.3万 - 项目类别:
Evaluating a Brief Intensive Intervention for Children with Fragile X Syndrome
评估针对脆性 X 综合征儿童的短期强化干预措施
- 批准号:
7529305 - 财政年份:2008
- 资助金额:
$ 17.3万 - 项目类别:
Evaluating a Brief Intensive Intervention for Children with Fragile X Syndrome
评估针对脆性 X 综合征儿童的短期强化干预措施
- 批准号:
8277961 - 财政年份:2008
- 资助金额:
$ 17.3万 - 项目类别:
Evaluating a Brief Intensive Intervention for Children with Fragile X Syndrome
评估针对脆性 X 综合征儿童的短期强化干预措施
- 批准号:
7689271 - 财政年份:2008
- 资助金额:
$ 17.3万 - 项目类别:
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