Core 5 - Rapid Multipathogen Detection For POCT and Natioal Disaster Readiness

核心5。中心的管理 领导愿景、中心主题和公共卫生。Kost博士（PI），美国和泰国 研究小组报告了卡特里娜飓风和2005年海啸的实地调查结果， 美国临床病理学杂志，2006年10月（Kost 2006 E）。2006年12月，他 关于POCT和灾难准备的教育简报出现在医学实验室观察员中 (Kost 2006 F）。观察和认识医生、护士、 和救援人员的启发中心的主题危急紧急灾难护理。基本上，如果没有 适当或足够的POC和重症监护检测设备，这些国家的卫生保健工作者 灾难后被迫采用经验医学，而不是循证医学。的POC 技术研究网络可以帮助纠正这种情况！ POCT的环境压力测试几个月前开始在POCT的CTR。结果 表明POCT试剂不能承受极端温度和其他困难 在灾难救援过程中遇到的问题（见核心2，“研究进展报告”）。斯蒂芬妮 POCT-CTR研究员Sumner提交了一份摘要（Sumner 2007），“环境限制 在2004年12月25日至26日在日内瓦举行的 美国临床化学协会（AACC）将于2007年7月在圣地亚哥举行。 博士科斯特将主持并在AACC研讨会上发言，“诊断保健 重症监护和灾难准备策略-准备护理点和重症监护 测试：海啸，卡特里娜飓风，地震和DMATs。“他提名的朱莉医生 Geberding，疾病预防控制中心的负责人，接受了邀请，在全体会议上发言之前， 研讨会 这些“领先”举措和多重病原体检测的临床研究 核心1中描述的支持我们的中心主题危重-紧急-灾难护理。早期工作 还推出了公共使用POC设备的环境标准概念 健康虽然POCT已经发展到更小、更智能、更快和更便宜，但它还不健壮 或在农村、紧急情况和灾难环境中连接（Kost 2006 E和2006 J）， 多重病原体检测落后于其他领域的进展，例如快速索引 急性冠状动脉综合征超声胸痛多心脏生物标志物POCT分析 中心（Kost 2005 B）。 因此，我们中心的使命是开发完全具备现场能力的POCT，包括 病原体检测，诊断结果正确解释，整合和合成， 快速医疗诊断、监测和治疗。我们的行政计划将允许我们 实现这些目标

Core 5. Administration of the Center Leadership Vision, Center Theme, and Public Health. Dr. Kost (PI) with US and Thai research teams reported field survey results from Hurricane Katrina and the 2005 tsunami in the American Journal of Clinical Pathology in October 2006 (Kost 2006E). In December 2006 his education brief on POCT and disaster preparedness appeared in Medical Laboratory Observer (Kost 2006F). Observation and awareness of the problems encountered by physicians, nurses, and rescuers inspired the Center theme of critical-emergencv-disaster care. Basically, without suitable or adequate POC and critical care testing devices, health care workers in these world disasters were forced to practice empirical, rather than evidence-based medicine. The POC Technologies Research Network can help correct this situation! Environmental stress testing of POCT began months ago at the POCT'CTR. Results show that POCT reagents will not withstand temperature extremes and other hardships encountered during disaster rescues (see Core 2, "Research Progress Report"). Stephanie Sumner, POCT-CTR researcher, submitted an abstract (Sumner 2007), "Environmental Limits of POCT: Relevance to Disaster Readiness" (see Appendix), to the national meeting of the American Association for Clinical Chemistry (AACC) to be held in San Diego in July 2007. Dr. Kost will moderate and speak in the AACC Symposium, "Diagnostic Health Care Strategies for Critical Care and Disaster Readiness¿Preparing Point-of-Care and Critical Care Testing: The Tsunami, Hurricane Katrina, Earthquakes, and DMATs." His nominee, Dr. Julie Geberding, Head of the CDC, accepted an invitation to speak in the Plenary session prior to his Symposium. These "head start" initiatives and the clinical research on multiplexed pathogen detection described in Core 1 support our Center theme of critical-emergency-disaster care. Early work also has launched the concept of environmental standards for POC devices used in public health. While POCT has evolved to be smaller, smarter, faster, and cheaper, it is not yet robust or connected in rural, emergency, and disaster settings (Kost 2006E and 2006J) and wholeblood multiplexed pathogen detection lags advances in other areas, such as rapid indexed interpretation of multiple cardiac biomarker POCT in acute coronary syndrome for US chest pain centers (Kost 2005B). The mission of our Center, therefore, is to develop fully field-capable POCT, including pathogen detection, with diagnostic results properly interpreted, integrated, and synthesized for rapid medical diagnosis, monitoring, and treatment. Our administrative plan will allow us to achieve these goals