SNPs in Patients with and without Diabetic Macular Edema

这是一项遗传关联研究，评估血管内皮生长因子（VEGF）、促红细胞生成素（EPO）、内皮素-1 （EDN1）和活化糖基化终产物（AGE）基因的单核苷酸多态性（snp）是否影响二甲醚的发生和进展。所有参与者都将提供血液样本，接受眼部检查、光学相干断层扫描（OCT）和可能的荧光素血管造影（FA）。他们还将讨论他们的医疗、家庭和社会历史。患有二甲醚的病例参与者和未患有二甲醚的对照组参与者将被允许根据本协议在NEI继续接受常规眼科治疗。

This is a genetic association study evaluating whether single nucleotide polymorphisms (SNPs) in vascular endothelial growth facotr (VEGF),erythropoietin (EPO), endothelin-1 (EDN1) and activated glycation end products (AGE) genes affect the development and progression of DME. All participants will provide a blood sample, undergo an eye examination, optical coherence tomography (OCT) and potentially fluorescein angiography (FA). They will also discuss their medical, family and social history. Case participants with DME and control participants without DME will be allowed to continue receiving conventional eye treatment at the NEI under this protocol. The primary outcome variable is the genotype frequency of SNPs in the above specific genes of DME and control participants. Secondary outcomes are serum levels of VEGF, EPO, EDN1, AGE and ophthalmic measurements (visual acuity and imaging results such as FA and OCT results). Additionally, longitudinal data about response to treatment of diabetic macular edema will be gathered to attempt to discern a genetic predictor of response to particular treatment.