CALCIUM-INDEPENDENT PLA2BETA IN BETA-CELL APOPTOSIS

β 细胞凋亡中钙独立的 PLA2BETA

• 批准号: 8206541
• 负责人: SASANKA RAMANADHAM
• 金额: $ 29.22万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8206541
• 关键词: Affect; Apoptosis; Apoptotic; Arachidonic Acids; Autoimmune Process; Beta Cell; Biochemical; Biological Assay; Calcium; Cell Death; Cell physiology; Cells; Ceramides; Confocal Microscopy; Consensus Sequence; DNA; Dependence; Development; Diabetes Mellitus; Evolution; Exhibits; Flow Cytometry; Fluorescence Microscopy; Future; Generations; Genetic; Glucose; Glucosylceramides; Glutathione; Grant; Health; Human; Hydrolysis; Hyperglycemia; Immunoblotting; In Situ Nick-End Labeling; Inbred NOD Mice; Insulin-Dependent Diabetes Mellitus; Islet Cell; Islets of Langerhans; Knockout Mice; Link; Lipase; Lipids; Lysophosphatidylcholines; Mass Spectrum Analysis; Membrane; Metabolic Diseases; Mitochondria; Modeling; Molecular; Molecular Biology; Monitor; Mus; Mutate; Mutation; Nitric Oxide; Nitric Oxide Pathway; Non-Insulin-Dependent Diabetes Mellitus; Organelles; Outcome; Pathway interactions; Phospholipase A2; Phospholipids; Predisposition; Process; Proteins; Protocols documentation; Radiolabeled; Reactive Oxygen Species; Resistance; Role; Spectrometry, Mass, Electrospray Ionization; Sphingomyelinase; Sphingomyelins; Staining method; Stains; Stimulus; Streptozocin; Stress; Therapeutic Intervention; Time; arachidonate; arachidonyl-coenzyme A; caspase-3; cytokine; diabetic; in vivo; inhibitor/antagonist; islet; lipid mediator; mouse development; mouse model; prevent; radiotracer; stimulus processing; tool